ERVV-2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endogenous retrovirus group V member 2 Env polyprotein Alternative name(s): HERV-V_19q13.41 provirus ancestral Env polyprotein 2
Gene namesⁱ	Name:ERVV-2 Synonyms:ENVV2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000268964.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:39051 ERVV-2
neXtProtⁱ	NX_B6SEH9

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 321	ExtracellularSequence analysisAdd BLAST	300
Transmembraneⁱ	322 – 342	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	343 – 456	CytoplasmicSequence analysisAdd BLAST	114
Transmembraneⁱ	457 – 477	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	478 – 535	ExtracellularSequence analysisAdd BLAST	58

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	100271846

DisGeNETⁱ

100271846

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_0000411001	22 – 535	Endogenous retrovirus group V member 2 Env polyproteinAdd BLAST		514

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	68	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	B6SEH9
PRIDEⁱ	B6SEH9
ProteomicsDBⁱ	6249

PTM databases

iPTMnetⁱ	B6SEH9
PhosphoSitePlusⁱ	B6SEH9

Expressionⁱ

Tissue specificityⁱ

Expressed in placenta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000268964 Expressed in 4 organ(s), highest expression level in placenta
ExpressionAtlasⁱ	B6SEH9 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B6SEH9
SMRⁱ	B6SEH9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the gamma type-C retroviral envelope protein family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J8IS Eukaryota ENOG4111C12 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00690000102286
HOVERGENⁱ	HBG105654
InParanoidⁱ	B6SEH9
OMAⁱ	LFLFGPC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04CH

Family and domain databases

InterProⁱ	View protein in InterPro IPR018154 TLV/ENV_coat_polyprotein
PANTHERⁱ	PTHR10424 PTHR10424, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00429 TLV_coat, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

B6SEH9-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MTEKFLFLYL SLLPMPLLSQ AQWNENSLVS FSKIIASGNH LSNCWICHNF 
        60         70         80         90        100
ITRSSSYQYI LVRNFSLNLT FGSGIPEGQH KSVPLQVSLA NSAHQVPCLD 
       110        120        130        140        150
LTPPFNQSSK TSFYFYNCSS LNQTCCPCPE GHCDRKNTSE EGFPSPTIHP 
       160        170        180        190        200
MSFSPAGCHP NLTHWCPAKQ MNDYRDKSPQ NRCAAWEGKE LITWRVLYSL 
       210        220        230        240        250
PKAHTVPTWP KSTVPLGGPL SPACNQTIPA GWKSQLHKWF DSHIPRWACT 
       260        270        280        290        300
PPGYVFLCGP QKNKLPFDGS PKITYSTPPV ANLYTCINNI QHTGECAVGL 
       310        320        330        340        350
LGPRGIGVTI YNTTQPRQKR ALGLILAGMG AAIGMIAPWG GFTYHDVTLR 
       360        370        380        390        400
NLSRQIDNIA KSTRDSISKL KASIDSLANV VMDNRLALDY LLAEQGGVCA 
       410        420        430        440        450
VINKSCCVYV NNSGAIEEDI KKIYDEATWL HDFGKGGASA RAIWEAVKSA 
       460        470        480        490        500
LPSLNWFVPL LGPATVILLL FLFGPCFFNL LIKCVSSRIK QFHMKSPQME 
       510        520        530 
RYQLSVIGGP STYKHISPLD ASGQRFRETM EEFSL

Length:535

Mass (Da):59,317

Last modified:December 16, 2008 - v1

Checksum:ⁱ42A12AA10BC6D3A7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EU853143 Genomic DNA Translation: ACI62854.1 AC010328 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS59420.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001177984.1, NM_001191055.1
UniGeneⁱ	Hs.420445

Genome annotation databases

Ensemblⁱ	ENST00000601417; ENSP00000472919; ENSG00000268964
GeneIDⁱ	100271846
KEGGⁱ	hsa:100271846

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
B6SEH9	Envelope protein ENVV2		HUMAN		535	UniRef100_B6SEH9

Protein	Similar proteins		Species	Score	Length	Source
B6SEH9	Envelope protein ENVV2		HUMAN		535	UniRef90_B6SEH9
Uncharacterized protein		NOMLE		537
Envelope protein ENVV2		HYLLA		537
ERVV-2 isoform 1		PANTR		535
Envelope glycoprotein		PONAB		535
+7

Protein	Similar proteins		Species	Score	Length	Source
B6SEH9	Endogenous retrovirus group V member 1 Env polyprotein		HUMAN		477	UniRef50_B6SEH8
Envelope glycoprotein		CHLAE		544
Envelope protein ENVV1		MACMU		544
Envelope protein ENVV1		PAPPA		544
Envelope glycoprotein		PANTR		542
+57

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	EU853143 Genomic DNA Translation: ACI62854.1 AC010328 Genomic DNA No translation available.
CCDSⁱ	CCDS59420.1
RefSeqⁱ	NP_001177984.1, NM_001191055.1
UniGeneⁱ	Hs.420445

3D structure databases

ProteinModelPortalⁱ	B6SEH9
SMRⁱ	B6SEH9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

iPTMnetⁱ	B6SEH9
PhosphoSitePlusⁱ	B6SEH9

Proteomic databases

PaxDbⁱ	B6SEH9
PRIDEⁱ	B6SEH9
ProteomicsDBⁱ	6249

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000601417; ENSP00000472919; ENSG00000268964
GeneIDⁱ	100271846
KEGGⁱ	hsa:100271846

Organism-specific databases

CTDⁱ	100271846
DisGeNETⁱ	100271846
EuPathDBⁱ	HostDB:ENSG00000268964.1
GeneCardsⁱ	ERVV-2
HGNCⁱ	HGNC:39051 ERVV-2
neXtProtⁱ	NX_B6SEH9
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J8IS Eukaryota ENOG4111C12 LUCA
GeneTreeⁱ	ENSGT00690000102286
HOVERGENⁱ	HBG105654
InParanoidⁱ	B6SEH9
OMAⁱ	LFLFGPC
OrthoDBⁱ	EOG091G04CH

Miscellaneous databases

ChiTaRSⁱ	ERVV-2 human
GenomeRNAiⁱ	100271846
Protein Ontology More...PROⁱ	PR:B6SEH9

Gene expression databases

Bgeeⁱ	ENSG00000268964 Expressed in 4 organ(s), highest expression level in placenta
ExpressionAtlasⁱ	B6SEH9 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR018154 TLV/ENV_coat_polyprotein
PANTHERⁱ	PTHR10424 PTHR10424, 1 hit
Pfamⁱ	View protein in Pfam PF00429 TLV_coat, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ERVV2_HUMAN
Accessionⁱ	B6SEH9Primary (citable) accession number: B6SEH9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 28, 2011
	Last sequence update:	December 16, 2008
	Last modified:	November 7, 2018
	This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, ERV, Reference proteome, Transposable element

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B6SEH9 (ERVV2_HUMAN)

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Endogenous retrovirus group V member 2 Env polyprotein

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ