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Protein

Endogenous retrovirus group V member 2 Env polyprotein

Gene

ERVV-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous retrovirus group V member 2 Env polyprotein
Alternative name(s):
HERV-V_19q13.41 provirus ancestral Env polyprotein 2
Gene namesi
Name:ERVV-2
Synonyms:ENVV2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000268964.1
HGNCiHGNC:39051 ERVV-2
neXtProtiNX_B6SEH9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 321ExtracellularSequence analysisAdd BLAST300
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 456CytoplasmicSequence analysisAdd BLAST114
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Topological domaini478 – 535ExtracellularSequence analysisAdd BLAST58

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100271846

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000041100122 – 535Endogenous retrovirus group V member 2 Env polyproteinAdd BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiB6SEH9
PRIDEiB6SEH9
ProteomicsDBi6249

PTM databases

iPTMnetiB6SEH9
PhosphoSitePlusiB6SEH9

Expressioni

Tissue specificityi

Expressed in placenta.1 Publication

Gene expression databases

BgeeiENSG00000268964 Expressed in 4 organ(s), highest expression level in placenta
ExpressionAtlasiB6SEH9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliB6SEH9
SMRiB6SEH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8IS Eukaryota
ENOG4111C12 LUCA
GeneTreeiENSGT00690000102286
HOVERGENiHBG105654
InParanoidiB6SEH9
OMAiLFLFGPC
OrthoDBiEOG091G04CH

Family and domain databases

InterProiView protein in InterPro
IPR018154 TLV/ENV_coat_polyprotein
PANTHERiPTHR10424 PTHR10424, 1 hit
PfamiView protein in Pfam
PF00429 TLV_coat, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6SEH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEKFLFLYL SLLPMPLLSQ AQWNENSLVS FSKIIASGNH LSNCWICHNF
60 70 80 90 100
ITRSSSYQYI LVRNFSLNLT FGSGIPEGQH KSVPLQVSLA NSAHQVPCLD
110 120 130 140 150
LTPPFNQSSK TSFYFYNCSS LNQTCCPCPE GHCDRKNTSE EGFPSPTIHP
160 170 180 190 200
MSFSPAGCHP NLTHWCPAKQ MNDYRDKSPQ NRCAAWEGKE LITWRVLYSL
210 220 230 240 250
PKAHTVPTWP KSTVPLGGPL SPACNQTIPA GWKSQLHKWF DSHIPRWACT
260 270 280 290 300
PPGYVFLCGP QKNKLPFDGS PKITYSTPPV ANLYTCINNI QHTGECAVGL
310 320 330 340 350
LGPRGIGVTI YNTTQPRQKR ALGLILAGMG AAIGMIAPWG GFTYHDVTLR
360 370 380 390 400
NLSRQIDNIA KSTRDSISKL KASIDSLANV VMDNRLALDY LLAEQGGVCA
410 420 430 440 450
VINKSCCVYV NNSGAIEEDI KKIYDEATWL HDFGKGGASA RAIWEAVKSA
460 470 480 490 500
LPSLNWFVPL LGPATVILLL FLFGPCFFNL LIKCVSSRIK QFHMKSPQME
510 520 530
RYQLSVIGGP STYKHISPLD ASGQRFRETM EEFSL
Length:535
Mass (Da):59,317
Last modified:December 16, 2008 - v1
Checksum:i42A12AA10BC6D3A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU853143 Genomic DNA Translation: ACI62854.1
AC010328 Genomic DNA No translation available.
CCDSiCCDS59420.1
RefSeqiNP_001177984.1, NM_001191055.1
UniGeneiHs.420445

Genome annotation databases

EnsembliENST00000601417; ENSP00000472919; ENSG00000268964
GeneIDi100271846
KEGGihsa:100271846

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU853143 Genomic DNA Translation: ACI62854.1
AC010328 Genomic DNA No translation available.
CCDSiCCDS59420.1
RefSeqiNP_001177984.1, NM_001191055.1
UniGeneiHs.420445

3D structure databases

ProteinModelPortaliB6SEH9
SMRiB6SEH9
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiB6SEH9
PhosphoSitePlusiB6SEH9

Proteomic databases

PaxDbiB6SEH9
PRIDEiB6SEH9
ProteomicsDBi6249

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000601417; ENSP00000472919; ENSG00000268964
GeneIDi100271846
KEGGihsa:100271846

Organism-specific databases

CTDi100271846
DisGeNETi100271846
EuPathDBiHostDB:ENSG00000268964.1
GeneCardsiERVV-2
HGNCiHGNC:39051 ERVV-2
neXtProtiNX_B6SEH9
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8IS Eukaryota
ENOG4111C12 LUCA
GeneTreeiENSGT00690000102286
HOVERGENiHBG105654
InParanoidiB6SEH9
OMAiLFLFGPC
OrthoDBiEOG091G04CH

Miscellaneous databases

ChiTaRSiERVV-2 human
GenomeRNAii100271846
PROiPR:B6SEH9

Gene expression databases

BgeeiENSG00000268964 Expressed in 4 organ(s), highest expression level in placenta
ExpressionAtlasiB6SEH9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR018154 TLV/ENV_coat_polyprotein
PANTHERiPTHR10424 PTHR10424, 1 hit
PfamiView protein in Pfam
PF00429 TLV_coat, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERVV2_HUMAN
AccessioniPrimary (citable) accession number: B6SEH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, ERV, Reference proteome, Transposable element

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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