UniProtKB - B6SEH9 (ERVV2_HUMAN)
Protein
Endogenous retrovirus group V member 2 Env polyprotein
Gene
ERVV-2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Endogenous retrovirus group V member 2 Env polyproteinAlternative name(s): HERV-V_19q13.41 provirus ancestral Env polyprotein 2 |
Gene namesi | Name:ERVV-2 Synonyms:ENVV2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000268964.1 |
HGNCi | HGNC:39051 ERVV-2 |
neXtProti | NX_B6SEH9 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 321 | ExtracellularSequence analysisAdd BLAST | 300 | |
Transmembranei | 322 – 342 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 343 – 456 | CytoplasmicSequence analysisAdd BLAST | 114 | |
Transmembranei | 457 – 477 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 478 – 535 | ExtracellularSequence analysisAdd BLAST | 58 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 100271846 |
Polymorphism and mutation databases
BioMutai | ERVV-2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000411001 | 22 – 535 | Endogenous retrovirus group V member 2 Env polyproteinAdd BLAST | 514 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | B6SEH9 |
PaxDbi | B6SEH9 |
PRIDEi | B6SEH9 |
ProteomicsDBi | 6249 |
PTM databases
iPTMneti | B6SEH9 |
PhosphoSitePlusi | B6SEH9 |
Expressioni
Tissue specificityi
Expressed in placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000268964 Expressed in 4 organ(s), highest expression level in placenta |
ExpressionAtlasi | B6SEH9 baseline and differential |
Structurei
3D structure databases
ProteinModelPortali | B6SEH9 |
SMRi | B6SEH9 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the gamma type-C retroviral envelope protein family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410J8IS Eukaryota ENOG4111C12 LUCA |
GeneTreei | ENSGT00940000164101 |
HOVERGENi | HBG105654 |
InParanoidi | B6SEH9 |
OMAi | LFLFGPC |
OrthoDBi | 389221at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR018154 TLV/ENV_coat_polyprotein |
PANTHERi | PTHR10424 PTHR10424, 1 hit |
Pfami | View protein in Pfam PF00429 TLV_coat, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
B6SEH9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEKFLFLYL SLLPMPLLSQ AQWNENSLVS FSKIIASGNH LSNCWICHNF
60 70 80 90 100
ITRSSSYQYI LVRNFSLNLT FGSGIPEGQH KSVPLQVSLA NSAHQVPCLD
110 120 130 140 150
LTPPFNQSSK TSFYFYNCSS LNQTCCPCPE GHCDRKNTSE EGFPSPTIHP
160 170 180 190 200
MSFSPAGCHP NLTHWCPAKQ MNDYRDKSPQ NRCAAWEGKE LITWRVLYSL
210 220 230 240 250
PKAHTVPTWP KSTVPLGGPL SPACNQTIPA GWKSQLHKWF DSHIPRWACT
260 270 280 290 300
PPGYVFLCGP QKNKLPFDGS PKITYSTPPV ANLYTCINNI QHTGECAVGL
310 320 330 340 350
LGPRGIGVTI YNTTQPRQKR ALGLILAGMG AAIGMIAPWG GFTYHDVTLR
360 370 380 390 400
NLSRQIDNIA KSTRDSISKL KASIDSLANV VMDNRLALDY LLAEQGGVCA
410 420 430 440 450
VINKSCCVYV NNSGAIEEDI KKIYDEATWL HDFGKGGASA RAIWEAVKSA
460 470 480 490 500
LPSLNWFVPL LGPATVILLL FLFGPCFFNL LIKCVSSRIK QFHMKSPQME
510 520 530
RYQLSVIGGP STYKHISPLD ASGQRFRETM EEFSL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU853143 Genomic DNA Translation: ACI62854.1 AC010328 Genomic DNA No translation available. |
CCDSi | CCDS59420.1 |
RefSeqi | NP_001177984.1, NM_001191055.1 |
UniGenei | Hs.420445 |
Genome annotation databases
Ensembli | ENST00000601417; ENSP00000472919; ENSG00000268964 |
GeneIDi | 100271846 |
KEGGi | hsa:100271846 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU853143 Genomic DNA Translation: ACI62854.1 AC010328 Genomic DNA No translation available. |
CCDSi | CCDS59420.1 |
RefSeqi | NP_001177984.1, NM_001191055.1 |
UniGenei | Hs.420445 |
3D structure databases
ProteinModelPortali | B6SEH9 |
SMRi | B6SEH9 |
ModBasei | Search... |
MobiDBi | Search... |
PTM databases
iPTMneti | B6SEH9 |
PhosphoSitePlusi | B6SEH9 |
Polymorphism and mutation databases
BioMutai | ERVV-2 |
Proteomic databases
jPOSTi | B6SEH9 |
PaxDbi | B6SEH9 |
PRIDEi | B6SEH9 |
ProteomicsDBi | 6249 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000601417; ENSP00000472919; ENSG00000268964 |
GeneIDi | 100271846 |
KEGGi | hsa:100271846 |
Organism-specific databases
CTDi | 100271846 |
DisGeNETi | 100271846 |
EuPathDBi | HostDB:ENSG00000268964.1 |
GeneCardsi | ERVV-2 |
HGNCi | HGNC:39051 ERVV-2 |
neXtProti | NX_B6SEH9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410J8IS Eukaryota ENOG4111C12 LUCA |
GeneTreei | ENSGT00940000164101 |
HOVERGENi | HBG105654 |
InParanoidi | B6SEH9 |
OMAi | LFLFGPC |
OrthoDBi | 389221at2759 |
Miscellaneous databases
ChiTaRSi | ERVV-2 human |
GenomeRNAii | 100271846 |
PROi | PR:B6SEH9 |
Gene expression databases
Bgeei | ENSG00000268964 Expressed in 4 organ(s), highest expression level in placenta |
ExpressionAtlasi | B6SEH9 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR018154 TLV/ENV_coat_polyprotein |
PANTHERi | PTHR10424 PTHR10424, 1 hit |
Pfami | View protein in Pfam PF00429 TLV_coat, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | ERVV2_HUMAN | |
Accessioni | B6SEH9Primary (citable) accession number: B6SEH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 28, 2011 |
Last sequence update: | December 16, 2008 | |
Last modified: | January 16, 2019 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, ERV, Reference proteome, Transposable elementDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM