Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kunitz-type serine protease inhibitor TCI

Gene
N/A
Organism
Ophiophagus hannah (King cobra) (Naja hannah)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine protease inhibitor that strongly inhibits chymotrypsin (Ki=84.6 nM) and trypsin (Ki=391 nM).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41 – 42Reactive bond for trypsinBy similarity2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI02.055

Names & Taxonomyi

Protein namesi
Recommended name:
Kunitz-type serine protease inhibitor TCI
Alternative name(s):
Trypsin and chymotrypsin bi-functional serine protease inhibitor
Short name:
OH-TCI
OrganismiOphiophagus hannah (King cobra) (Naja hannah)
Taxonomic identifieri8665 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeOphiophagus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000037747326 – 83Kunitz-type serine protease inhibitor TCIAdd BLAST58

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 81PROSITE-ProRule annotation
Disulfide bondi40 ↔ 64PROSITE-ProRule annotation
Disulfide bondi56 ↔ 77PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

TopDownProteomicsiB6RLX2

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

SMRiB6RLX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 81BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Belongs to the venom Kunitz-type family.Curated

Keywords - Domaini

Signal

Family and domain databases

CDDicd00109 KU, 1 hit
Gene3Di4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 1 hit
SUPFAMiSSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6RLX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSGRLLLLL GLLTLWAELT PVSGLGRPKF CELPAVSGFC KAYIPSFYYN
60 70 80
PDASACQKFI YGGCGGNANK FKTIEECHRT CVG
Length:83
Mass (Da):8,983
Last modified:December 16, 2008 - v1
Checksum:iBB14890B90D31BDC
GO

Mass spectrometryi

Molecular mass is 6339 Da from positions 25 - 83. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU246692 mRNA Translation: ABY74980.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU246692 mRNA Translation: ABY74980.1

3D structure databases

SMRiB6RLX2
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI02.055

Proteomic databases

TopDownProteomicsiB6RLX2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00109 KU, 1 hit
Gene3Di4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 1 hit
SUPFAMiSSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVKTCT_OPHHA
AccessioniPrimary (citable) accession number: B6RLX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 16, 2008
Last modified: October 25, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again