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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei170PROSITE-ProRule annotation1
Active sitei370PROSITE-ProRule annotation1
Active sitei432PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:PMAA_045500
OrganismiTalaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)
Taxonomic identifieri441960 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces
Proteomesi
  • UP000001294 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:PMAA_045500

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 504LumenalSequence analysisAdd BLAST486
Transmembranei505 – 525HelicalSequence analysisAdd BLAST21
Topological domaini526 – 626CytoplasmicSequence analysisAdd BLAST101

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000041193419 – 626Pheromone-processing carboxypeptidase kex1Add BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi429N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi441960.XP_002151727.1

Structurei

3D structure databases

SMRiB6QQZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B6QQZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGKALLLLL SSPICAWAQS AADYYVKSIP GQPDGPLLKM HAGHVEVDAE
60 70 80 90 100
TNGHLFFWHF QNRHIANRQR TILWLNGGPG CSSMDGALME IGPYRVKDDH
110 120 130 140 150
TLIYNNGSWD EFANLLFVDQ PVGTGFSYVN TNSYLHDLDH VAAHMITFLE
160 170 180 190 200
KWFAMFPEYE SDDLYIAGES YAGQYIPHIA RAIVERNKNI QRNQQHWPIK
210 220 230 240 250
GLLIGNGWIS PRDQYPANLQ YAYAEGIVKE GTAIANELDG IEKSCDEQLN
260 270 280 290 300
APGAGDLVDI RQCESILNKL LDLTRTSDDQ CINVYDIRLK DATCGNAWPP
310 320 330 340 350
DLDQMTDYLR RADVGAALNL DNGKANGWTE CNNQVTANFR MGHNGVPSIQ
360 370 380 390 400
LLPGLIESGV KVLLFSGDRD LICNHLGTES LIHNMKWSGG TGFETKPGVW
410 420 430 440 450
APRRGWTFEG EAAGYYQQAR NLTYVLFYNA SHMVPYDFPR RTRDMVDRFI
460 470 480 490 500
NVDIANIGGP PADSRLDGEK LPQTSVGNTT SSTSGTDQVD EAKLKDAEWK
510 520 530 540 550
AYTKSGEAAL IVVIIGVSVW GFFIWRARQR AARDGTSPTK KGYRAVYQDG
560 570 580 590 600
VDNNSSTDGA GLLSRFRNQS NSNSSRDLEA RDFDEAELDS LTPNLQNGHE
610 620
RDHYVIGEED EDEDNDIGNG AKSSLH
Length:626
Mass (Da):69,623
Last modified:December 16, 2008 - v1
Checksum:iC2B374719456DD9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995904 Genomic DNA Translation: EEA20727.1
RefSeqiXP_002151727.1, XM_002151691.1

Genome annotation databases

EnsemblFungiiEEA20727; EEA20727; PMAA_045500
GeneIDi7029168

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS995904 Genomic DNA Translation: EEA20727.1
RefSeqiXP_002151727.1, XM_002151691.1

3D structure databases

SMRiB6QQZ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi441960.XP_002151727.1

Protein family/group databases

MEROPSiS10.007

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEA20727; EEA20727; PMAA_045500
GeneIDi7029168

Organism-specific databases

EuPathDBiFungiDB:PMAA_045500

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_TALMQ
AccessioniPrimary (citable) accession number: B6QQZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: December 16, 2008
Last modified: May 10, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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