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Entry version 72 (29 Sep 2021)
Sequence version 1 (16 Dec 2008)
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Protein

DNA-directed RNA polymerase subunit

Gene

BN1205_107750

Organism
Toxoplasma gondii (strain ATCC 50861 / VEG)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationARBA annotation, Transferase
Biological processTranscription
LigandMagnesiumARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BN1205_107750Imported, TGVEG_306290Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50861 / VEG)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri432359 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002226 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
ToxoDB:TGVEG_306290

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotationARBA annotation, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B6KRB8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

ARBA annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5811.TGME49_106290

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini320 – 626RPOLA_NInterPro annotationAdd BLAST307

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 79DisorderedSequence analysisAdd BLAST79
Regioni1277 – 1305DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 28Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi46 – 79Polar residuesSequence analysisAdd BLAST34
Compositional biasi1279 – 1300Basic and acidic residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0261, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B6KRB8

Identification of Orthologs from Complete Genome Data

More...
OMAi
ADIMAFT

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02736, RNAP_III_Rpc1_C, 1 hit
cd02583, RNAP_III_RPC1_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.30, 1 hit
1.10.274.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000722, RNA_pol_asu
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR035698, RNAP_III_Rpc1_C
IPR035697, RNAP_III_RPC1_N
IPR038120, Rpb1_funnel_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 1 hit
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00663, RPOLA_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B6KRB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATGDGDKDR RSDSGDEGET EKEGGLRASQ RMPARPTEPG ESFLDVTMTD
60 70 80 90 100
YSSSSSSSSS SSSSASSSSS SSSSSSSSSS LTAAHLMQNA QLRSSFLRKE
110 120 130 140 150
MVEEKSGALM TVDAVQFDVL SGEEISRYSE VEIHNREIYV NMTNTPHPYG
160 170 180 190 200
VLDLRLGPNK SDSRCQTCGH TLLQCTGHWG YMDLQAPVYH VGYFKYVLQI
210 220 230 240 250
LYCICKTCAA LLQPPEQKEK LLLRIRRHQS DPIVKRLLFK RTVEACKKVS
260 270 280 290 300
KCFECGAPQG VLKRVVKPSL DQFMKIRHVV KSKEGRAMTV EDDLDPLYVK
310 320 330 340 350
NLLERIRPSE CEILDIVSPE KLLLSRLLVP PSCIRPSVTI GEQGTTEDDL
360 370 380 390 400
TCVLSDIAEL NNVLQSHVKA GFHTNQFLGI WEFLQLQCTR LINADAPAVS
410 420 430 440 450
QLLASKNISK PGRGICQRLK GKEGRFRGNL SGKRVDFSGR TVISPDPNAN
460 470 480 490 500
VYEVVVPEWV AKRLTFPERV NRVNIEVLRA AVLKGCSDWP GACYVNKVDG
510 520 530 540 550
SKCSLRYANR RQVAENLQIG DVVERHLCNG DVVLFNRQPS LHRMSIMAHR
560 570 580 590 600
ARVMPWRTFR FNECVCSPYN ADFDGDEMNL HLPQTHEARA EALYLMGVVN
610 620 630 640 650
NLVTPKNGEP LIAATQDFLS SSYMLTHKDV FLTRDQFCLI CSYFTDGLSR
660 670 680 690 700
VDLPPPTILK PVELWTGKQV ISVLLRPNRN SFVMVNFQLK EREFSAARIP
710 720 730 740 750
PGEAPFMCPS DAYVIFRHSE LVAGCIGKKV LGDAKFGLFF HLIRDNSPAQ
760 770 780 790 800
AAACMGRIAK LSARWFANRG MTIGIDDVTP SPTLLAAKKD ILNHGYNLVA
810 820 830 840 850
QEIQMYKKGA LQPHPGCTLE QTLEVRVKSI LDDLRNEAGK ACNRVLHPLN
860 870 880 890 900
KPLIMFNSGA KGALINIAQM IACVGQQNVS GQRIQNGFVS RTLPHFPLNC
910 920 930 940 950
RDAKSRGFVA SSFYSGLQPD EFFFHTMSGR EGLVDTAVKT AETGYMQRRL
960 970 980 990 1000
MKALEDLSIR YDNSVRTSDG QIVQFVYGDD GLNPAMMEDK NQSMCLDKVF
1010 1020 1030 1040 1050
QHISSLLHIK PLHVLPPSSP LCAPASSPAA PNWPEVARDK ILPPDSDEVL
1060 1070 1080 1090 1100
TALLQRYQQM DIRLVEASQR QASGNVEPPR AVYEIFSRLG ASDGGHGKEK
1110 1120 1130 1140 1150
RAREDWAKLM KLPRSYRQKL AILLQTAASG NASTSRFCQQ VRGNLLAHVA
1160 1170 1180 1190 1200
VYEWLPIREQ HVPLLPFEIL KWSAFLLTRT AEVVPLPLCE HQQVALEEAP
1210 1220 1230 1240 1250
THQSGTERVR LFQDELWAWL ERKAADVAEY RESDREKPGL TQDSYDSLLA
1260 1270 1280 1290 1300
CWRRQGFGIE RRQWIVPDCE TALQARGVKT KSEAEDPSAA GDEETDMVSR
1310 1320 1330 1340 1350
DTWQTPDMSR SFPEFEGHEK GLAPTPGCPG SSSGCRNGDL GLPERKWKFS
1360 1370 1380 1390 1400
KHQWVTVRHI LEFLRCSWRK YVKAISEAGE AVGAMGAQSI GEPGTQMTLK
1410 1420 1430 1440 1450
TFHFAGVASM NVTLGVPRIK EIINAAQKIQ TPIIVVPLVN DEDYNYAVMV
1460 1470 1480 1490 1500
KNRIEKTLLS ECCSYIKEVY APDGAWLVVK LDQHTIRKLF LDINANTVKD
1510 1520 1530 1540 1550
AILRQTAVNK VRITKNSVEI INEWKVRVMP PGGNQIFFQL QALKLGLLNI
1560 1570 1580 1590 1600
VLCGHKDVKR GVIKCEQVEQ PDKTKKTVYG LAVEGYGLRD VMGTQGVKAL
1610 1620 1630 1640 1650
QATSNHVMEV AQILGIEAAR AVIISEIRKC MDAYSMDIDC RHMTLLGDVM
1660 1670 1680 1690 1700
TFRGEVLGIN RFGIQKMRAS TLMLASFEET NEHLFEAAVH HRADPVKGVS
1710 1720 1730 1740
ECIIMGKQVS LGTGSFDLLL SQSGAPLASD YGGVLSAYGL PEKHTV
Length:1,746
Mass (Da):194,352
Last modified:December 16, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D9707F070074AD6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN714499 Genomic DNA Translation: CEL76268.1
AAYL02000319 Genomic DNA Translation: ESS29010.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
ESS29010; ESS29010; TGVEG_306290

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN714499 Genomic DNA Translation: CEL76268.1
AAYL02000319 Genomic DNA Translation: ESS29010.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5811.TGME49_106290

PTM databases

SwissPalmiB6KRB8

Genome annotation databases

EnsemblProtistsiESS29010; ESS29010; TGVEG_306290

Organism-specific databases

VEuPathDBiToxoDB:TGVEG_306290

Phylogenomic databases

eggNOGiKOG0261, Eukaryota
InParanoidiB6KRB8
OMAiADIMAFT

Family and domain databases

CDDicd02736, RNAP_III_Rpc1_C, 1 hit
cd02583, RNAP_III_RPC1_N, 1 hit
Gene3Di1.10.132.30, 1 hit
1.10.274.100, 1 hit
InterProiView protein in InterPro
IPR000722, RNA_pol_asu
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR035698, RNAP_III_Rpc1_C
IPR035697, RNAP_III_RPC1_N
IPR038120, Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 1 hit
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit
SMARTiView protein in SMART
SM00663, RPOLA_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB6KRB8_TOXGV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B6KRB8
Secondary accession number(s): A0A0F7V807
, A0A0N5EDG6, B9QMD7, S8F1U6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: September 29, 2021
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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