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Entry version 69 (29 Sep 2021)
Sequence version 1 (16 Dec 2008)
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Protein

Phosphodiesterase

Gene

BN1205_022610

Organism
Toxoplasma gondii (strain ATCC 50861 / VEG)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseUniRule annotationARBA annotation
LigandMetal-bindingUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PhosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BN1205_022610Imported, TGVEG_233040Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii (strain ATCC 50861 / VEG)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri432359 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002226 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
ToxoDB:TGVEG_233040

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei290 – 308HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B6KJZ0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5811.TGME49_033040

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini994 – 1329PDEaseInterPro annotationAdd BLAST336

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 63DisorderedSequence analysisAdd BLAST63
Regioni945 – 967DisorderedSequence analysisAdd BLAST23
Regioni1391 – 1474DisorderedSequence analysisAdd BLAST84
Regioni1500 – 1661DisorderedSequence analysisAdd BLAST162

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 33Polar residuesSequence analysisAdd BLAST25
Compositional biasi1420 – 1457Basic and acidic residuesSequence analysisAdd BLAST38
Compositional biasi1458 – 1474Polar residuesSequence analysisAdd BLAST17
Compositional biasi1500 – 1531Polar residuesSequence analysisAdd BLAST32
Compositional biasi1532 – 1578Basic and acidic residuesSequence analysisAdd BLAST47
Compositional biasi1585 – 1612Polar residuesSequence analysisAdd BLAST28
Compositional biasi1632 – 1661Polar residuesSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3688, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B6KJZ0

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEGHEPG

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00077, HDc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1300.10, 1 hit
3.30.565.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036890, HATPase_C_sf
IPR003607, HD/PDEase_dom
IPR002073, PDEase_catalytic_dom
IPR036971, PDEase_catalytic_dom_sf
IPR023174, PDEase_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00233, PDEase_I, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00471, HDc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00126, PDEASE_I_1, 1 hit
PS51845, PDEASE_I_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B6KJZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVSPHRTSE RGSLPTGGEN GKHRFTQSGA LRRQSAAPGG AKRSTMTGFL
60 70 80 90 100
KAEPNPGSET QDLEATQRRL KSAHRRTMLP TWILTGLSLA YVLFEGGRLL
110 120 130 140 150
YETTLQQWSE EAILHIDKEI FFLHDFAAGF YSLAEQLTSD YCFLNFMNAH
160 170 180 190 200
SPPAAPTSTR EEVQNLISGY APSFCSWIKD LYFFEEPLAD TADRSTYQLL
210 220 230 240 250
NTTYICGERF ADLVQRINGN MVEVVQNYTL VKMRLIEMLA PLVDNRNWSP
260 270 280 290 300
HLLCDLDFSA GDLWACHDGL TALEQLRGQL SGYLGREWHL YSPILSIVIV
310 320 330 340 350
FILATLFFSR RHAFNAVFHT RFESLWAMLQ QIDQVLQRRL ENMVVIMQSV
360 370 380 390 400
IDDRMIGRLK VVSGIQSLLL SSESPAVMRQ FYRVMEHCTF ELIESLNLAS
410 420 430 440 450
QYVKLEMQSS TEGREMVNIR LLLDGCIQVY KNETRANGTS ISCVYAPTVP
460 470 480 490 500
TALAIDKLRL RTVLLQVLRF ALLEGKVTNA EVKLTAKKVF LGKAPSTIET
510 520 530 540 550
EKRNDLKNFD TQISIKCKME SAMTFSAVEL LDSAYLRLRR GKGIGFIYAK
560 570 580 590 600
KVLRELNGDI TITTTDSNEV IYDLYFQAMG RFHVKDFHVA FGTVKNAVAL
610 620 630 640 650
TMNVQQAKGY SQLAAVADLV GVKVIHVTSV AEAVEHMLSN RGHRIVSVFF
660 670 680 690 700
KDPSGVIRSQ LSSALPQSNS RNIPLVEVVA EGDILTRERL EESFRVANPS
710 720 730 740 750
DTSREVAIEI QERGRRGSTT QGRLLLRESH AFRQSKIVPI EEPLTTSDCV
760 770 780 790 800
TAMAIGAASF LSNRQASKDL LRNLSYGRRS FWDSLVTAFT ANTTRLDRRR
810 820 830 840 850
KWVNEIWRQV EFDAWKPVQQ FRGSVYPADR LFHKVSNMPI QNKYYAYFVA
860 870 880 890 900
GRINEVGFAT NVIDLYKNMV LDQRVYKLPE EKNMSFYELA QTRAYLLETG
910 920 930 940 950
QKNECLGADY NEDYLGKLLG AQIDPMDTTA LVKKVYEEFE VKSEIKVPEE
960 970 980 990 1000
EEPGGQEDEL PTAERTTEEF RWGNIPEYTV PSCITASVAR MDTVLCLAPS
1010 1020 1030 1040 1050
IASEARLNTY RENAPSIAVE FIFSWDFDIS SLQPEMSAKL AYELLIWCAD
1060 1070 1080 1090 1100
KAHISVPRET CEKFVLSVQQ NYSAMPFHNF NHALHAAQAV ILIAKDLSFQ
1110 1120 1130 1140 1150
HWFSYEDKFI IMLAALGHDM GHPGVSNEFL ISMRSFTSIL FNETAVLENY
1160 1170 1180 1190 1200
HTLLYMDLLK NSDLDILKML QPEAVQRARQ RIIAAILATD RALDMKLIDL
1210 1220 1230 1240 1250
LNDVKSKNEK VPVPAALLDP NVRDACLIHA ADHALSLLNF PLHRKWAEKM
1260 1270 1280 1290 1300
AIEMHFQNTM DEALKLPKSY CSLSRLTEAS LAGSQVTMID THYLPFFSAL
1310 1320 1330 1340 1350
AWYFPGDLDM RVAVMKANAA FWQHLRDEEM RKTVALNDNP EQEDWRSAKL
1360 1370 1380 1390 1400
QVISSKFVEN REKMHQKAAE MMQAEATDVF FDPYPMIVDQ SGNEGEEDSF
1410 1420 1430 1440 1450
AKGVMREKSG MGGYAIESRR RSADSSRGAE RRESDAEAHH SEATHAPKPD
1460 1470 1480 1490 1500
EKSQLDKNGQ RQSNSSGLEQ GSKAGVSCFQ RASLRARFVD AGVTIPATKQ
1510 1520 1530 1540 1550
PVLSETHASA TNDTSRGEQG NEKGNLDSTE QTTKIGDEEK EARTDEMVGD
1560 1570 1580 1590 1600
PEETREKHDP PTVSHFEDRS DHRQVDAPDS LPEAAPNVGS QNPNSAGTHP
1610 1620 1630 1640 1650
DTRATPSVSV PSNVADEEVA ERVPAPVPAD QSLSRTLLQS DEASQRKNQT
1660 1670 1680 1690 1700
KSLSNAESVD TEEMSAFVLD EVSGFFYDQQ GYVYDQQGNL RGYLDASGAF
1710 1720 1730
QAYSESELQY YAETMARVQD QEQADYAYPE G
Length:1,731
Mass (Da):194,880
Last modified:December 16, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DBAD0783BEBF60D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN714498 Genomic DNA Translation: CEL74970.1
AAYL02000018 Genomic DNA Translation: ESS35881.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
ESS35881; ESS35881; TGVEG_233040

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN714498 Genomic DNA Translation: CEL74970.1
AAYL02000018 Genomic DNA Translation: ESS35881.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5811.TGME49_033040

PTM databases

SwissPalmiB6KJZ0

Genome annotation databases

EnsemblProtistsiESS35881; ESS35881; TGVEG_233040

Organism-specific databases

VEuPathDBiToxoDB:TGVEG_233040

Phylogenomic databases

eggNOGiKOG3688, Eukaryota
InParanoidiB6KJZ0
OMAiNEGHEPG

Family and domain databases

CDDicd00077, HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR036890, HATPase_C_sf
IPR003607, HD/PDEase_dom
IPR002073, PDEase_catalytic_dom
IPR036971, PDEase_catalytic_dom_sf
IPR023174, PDEase_CS
PfamiView protein in Pfam
PF00233, PDEase_I, 1 hit
SMARTiView protein in SMART
SM00471, HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126, PDEASE_I_1, 1 hit
PS51845, PDEASE_I_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB6KJZ0_TOXGV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B6KJZ0
Secondary accession number(s): A0A0F7V4C2
, A0A0N5EBI2, B9Q4K4, S8EZN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: September 29, 2021
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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