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Protein

Sister chromatid cohesion protein solo

Gene

solo

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform solo and SMC1 function as partners in mediating sister chromatid and centromere cohesion in meiosis. Not required for sister chromatid arm cohesion or for mitotic chromatid segregation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • meiotic sister chromatid cohesion, centromeric Source: UniProtKB
  • multicellular organism development Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Meiosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sister chromatid cohesion protein solo1 Publication
Alternative name(s):
Sisters on the looseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:solo1 PublicationImported
ORF Names:CG46282Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0283440 solo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Premature loss of centromere cohesion and high non-disjunction of both homologous and sister chromatids at meiosis I and II.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003965151 – 1031Sister chromatid cohesion protein soloAdd BLAST1031

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22Phosphoserine1 Publication1
Modified residuei27Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B6JUP5

PRoteomics IDEntifications database

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PRIDEi
B6JUP5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B6JUP5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spermatocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0262526 Expressed in 10 organ(s), highest expression level in egg chamber

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B6JUP5 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B6JUP5 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
60902, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0293395

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati93 – 991Sequence analysis7
Repeati100 – 1062Sequence analysis7
Repeati107 – 1133Sequence analysis7
Repeati114 – 1204Sequence analysis7
Repeati121 – 1275Sequence analysis7

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni93 – 1275 X 7 AA tandem repeats of [FS]-R-G-G-[EQ]-G-GSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 130Gly-richSequence analysisAdd BLAST98
Compositional biasi635 – 669Arg-richSequence analysisAdd BLAST35

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0335 Eukaryota
ENOG410XNTI LUCA

KEGG Orthology (KO)

More...
KOi
K13982

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03JV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B6JUP5

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform solo1 Publication (identifier: B6JUP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDDWDDEPI VDTRGARGGD WSDDEDTAKS FSGEAEGDGV GGSGGEGGGY
60 70 80 90 100
QGGNRDVFGR IGGGRGGGAG GYRGGNRDGG GFHGGRREGE RDFRGGEGGF
110 120 130 140 150
RGGQGGSRGG QGGSRGGQGG FRGGEGGFRG RLYENEDAKE LPPIPSSCDK
160 170 180 190 200
DEVGAFIDQL DLSKYTTSLA LIRKLRDYLL TAFKALVNQA WASLEKLAQE
210 220 230 240 250
KRAQKAHQIR ETTDMMNRLM EDMGRLIREG EHEEANGIGM GFQSIDADCR
260 270 280 290 300
ADLSQWRNLQ QVVMPQSSEI RDGQTNRTSG TEGGRSGGLT DGDDLTEIQS
310 320 330 340 350
AAYAVYHQVL DRGYQTGRRL YDDNQGALRE DSIPTEDREH PENNQVDGST
360 370 380 390 400
YGVTRFLHWL SENFVTRHEI RAVRFGSPHM VFQSYDWPES PKQHISTVHQ
410 420 430 440 450
KGIFYSQPLI RTRIIATVAS EPNNSSSGQL SSMVNLARHQ RSQNQETPDG
460 470 480 490 500
IYVSRYNATG DEETPCSATG VPGRVVALRA SSTPNEHRSD PGLSFIPNLT
510 520 530 540 550
YEDGTIPSLA AGGAASTPLA PSLPAEHSLG LEMDSNTLVV PADADETRLV
560 570 580 590 600
GHPGSTVVRS RLGGPPASTP LLSFRPRLPV IDEEHHLRFT RVSRELQMSV
610 620 630 640 650
AFPPEETTLS EQREWGSIFR PRDEMVNYAE GPPPRQTQRA RRRSRTRRRR
660 670 680 690 700
NRIASAASPQ LTPERIVRRE EAFQSSRHIA ATFMSSLLQN AAGEVTTSSG
710 720 730 740 750
LAVTRSVKEI TTSVHITRNV LQEEVPPTTE ATTTSLEVAQ ATGYSDSGAC
760 770 780 790 800
MQSAAFSQDL PVVAPLEISG NASSDQASFD QALALLPPIN STPIGQHPIA
810 820 830 840 850
VFGPKTEIEI KPQKMDISNM MNTSVPPMPM EVDEVPLEVS NTLANMSDHA
860 870 880 890 900
YVTDIQILPS LQLNSLNLVS TNITDNAVNI APSTSTNDLQ TPSDRRTSMQ
910 920 930 940 950
NQLYRVSMND LAYISQHANV VRLMVDRQEE LGAQVSSLGP FKENSQGALN
960 970 980 990 1000
FSTMPAVKVY DPRIIQNIQK DKMRVVHGLF GALIRQSQVD MHNAPFIRNR
1010 1020 1030
KDALMAYRFL LELKTANIIS LSSDGRFFGL L
Length:1,031
Mass (Da):112,515
Last modified:December 16, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA18ED8D0593C959
GO
Isoform vas (identifier: P09052-1) [UniParc]FASTAAdd to basket
Also known as: A
The sequence of this isoform can be found in the external entry P09052.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:661
Mass (Da):72,331
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0S0WFC5A0A0S0WFC5_DROME
Sisters on the loose, isoform B
solo BG:DS00929.15, CG33678, CG43081, cgt, Dmel\CG46282
1,031Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ851162 mRNA Translation: ABI34808.1
AE014134 Genomic DNA Translation: AAZ66470.2
BT099809 mRNA Translation: ACV91646.1

NCBI Reference Sequences

More...
RefSeqi
NP_001027274.2, NM_001032103.2 [B6JUP5-1]
NP_001303323.1, NM_001316394.1 [B6JUP5-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.4715

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0445188; FBpp0401448; FBgn0283440 [B6JUP5-1]
FBtr0445189; FBpp0401449; FBgn0283440 [B6JUP5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26067079

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG46282

UCSC genome browser

More...
UCSCi
CG33678-RA d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ851162 mRNA Translation: ABI34808.1
AE014134 Genomic DNA Translation: AAZ66470.2
BT099809 mRNA Translation: ACV91646.1
RefSeqiNP_001027274.2, NM_001032103.2 [B6JUP5-1]
NP_001303323.1, NM_001316394.1 [B6JUP5-1]
UniGeneiDm.4715

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

BioGridi60902, 7 interactors
STRINGi7227.FBpp0293395

PTM databases

iPTMnetiB6JUP5

Proteomic databases

PaxDbiB6JUP5
PRIDEiB6JUP5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0445188; FBpp0401448; FBgn0283440 [B6JUP5-1]
FBtr0445189; FBpp0401449; FBgn0283440 [B6JUP5-1]
GeneIDi26067079
KEGGidme:Dmel_CG46282
UCSCiCG33678-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26067079
FlyBaseiFBgn0283440 solo

Phylogenomic databases

eggNOGiKOG0335 Eukaryota
ENOG410XNTI LUCA
KOiK13982
OrthoDBiEOG091G03JV
PhylomeDBiB6JUP5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
vas fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26067079

Gene expression databases

BgeeiFBgn0262526 Expressed in 10 organ(s), highest expression level in egg chamber
ExpressionAtlasiB6JUP5 differential
GenevisibleiB6JUP5 DM

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVASA2_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B6JUP5
Secondary accession number(s): Q4ABF3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: December 16, 2008
Last modified: December 5, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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