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Entry version 50 (26 Feb 2020)
Sequence version 1 (16 Dec 2008)
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Protein
Submitted name:

Cag pathogenicity island protein Y VirB10-like protein

Gene

cagY

Organism
Helicobacter pylori (strain P12)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
HPYL570508:G1GU0-567-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cag pathogenicity island protein Y VirB10-like proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cagYImported
Ordered Locus Names:HPP12_0534Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain P12)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri570508 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008198 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei209 – 234HelicalSequence analysisAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 192DisorderedSequence analysisAdd BLAST192
Regioni1579 – 1602DisorderedSequence analysisAdd BLAST24
Regioni1625 – 1653DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili330 – 350Sequence analysisAdd BLAST21
Coiled coili486 – 506Sequence analysisAdd BLAST21
Coiled coili625 – 645Sequence analysisAdd BLAST21
Coiled coili732 – 759Sequence analysisAdd BLAST28
Coiled coili809 – 829Sequence analysisAdd BLAST21
Coiled coili954 – 974Sequence analysisAdd BLAST21
Coiled coili1061 – 1081Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi27 – 67PolyampholyteSequence analysisAdd BLAST41
Compositional biasi68 – 83PolarSequence analysisAdd BLAST16
Compositional biasi86 – 110PolyampholyteSequence analysisAdd BLAST25
Compositional biasi111 – 125AcidicSequence analysisAdd BLAST15
Compositional biasi155 – 192PolyampholyteSequence analysisAdd BLAST38
Compositional biasi1625 – 1650PolyampholyteSequence analysisAdd BLAST26

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_236752_0_0_7

KEGG Orthology (KO)

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KOi
K12092

Identification of Orthologs from Complete Genome Data

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OMAi
YKDCVSR

Database of Orthologous Groups

More...
OrthoDBi
3686at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.128.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029285 CagY_I
IPR010853 CagY_M
IPR005498 T4SS_VirB10/TraB/TrbI
IPR042217 T4SS_VirB10/TrbI

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14585 CagY_I, 2 hits
PF07337 CagY_M, 30 hits
PF03743 TrbI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B6JLB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEENDKLET SKKTQQDSPQ DLSNEEATEV NHFEDLLKEE SSDNHLDNPT
60 70 80 90 100
EIKTNFDGDK LEETQTQMDS GGDETSESSN GSLADKLFKK ARKLVDNKRP
110 120 130 140 150
FTQQKNLDEE TQELNEEDDQ ENNEYQEETQ TGLIDDETSK KTQQDSPQDL
160 170 180 190 200
SNEEATEVNR FEDSLKEESS DQHLDNSAET QTNFDKDKSE EITNDSNDQE
210 220 230 240 250
IIKGSKKKYI ISGLVVAVLI VIILFSRSIF HYFMPLEDKS SRFSKDRNLY
260 270 280 290 300
VNDEIQIRQE YNRLLKERNE KGNMIDKNLF FNDDPNRTLY NYLNIAEIED
310 320 330 340 350
KNPLRAFYEC ISNGGNYEEC LKLIKDKKLQ DQMKKTLEAY KDCIKNAKTE
360 370 380 390 400
EERIKCLDLI KDENLKKSLL NQQKVQVALD CLKKAKTDEE RNECLKLIND
410 420 430 440 450
PEIREKFRKE LGLQKELQVY KDCIKNAKTE AEKNECLKGL SKEAIERLKQ
460 470 480 490 500
QVLDCLKNAK TDEERNECLK NIPQDLQKEL LADMSVKAYK DCVSKARNEK
510 520 530 540 550
EKKECEKLLT PEAKKKLEQQ VLDCLKNAKT DEERKKCLKD LPKDLQSDIL
560 570 580 590 600
AKESVKAYKD CVSQAKTEAE KKECEKLLTP EAKKLLEEEA KESVKAYLDC
610 620 630 640 650
VSQAKTEAEK KECEKLLTPE AKKLLEEAKK SVKAYLDCVS QAKNEAEKKE
660 670 680 690 700
CEKLLTPEAK KLLEQQALDC LKNAKTEADK KRCVKDLPKD LQKKVLAKES
710 720 730 740 750
VKAYLDCVSQ AKNEAEKKEC EKLLTPEARK LLEEAKESVK AYKDCVSKAR
760 770 780 790 800
NEKEKKECEK LLTPEAKKLL EEEAKESVKA YLDCVSQAKT EAEKKECEKL
810 820 830 840 850
LTPEARKLLE EAKESLKAYK DCLSQARNEE ERRACEKLLT PEARKLLEQQ
860 870 880 890 900
ALDCLKNAKT DEERKKCLKD LPKDLQSDIL AKESVKAYKD CVSQAKTEAE
910 920 930 940 950
KKECEKLLTP EAKKLLEEAK KSVKAYLDCV SQAKTEAEKK ECEKLLTPEA
960 970 980 990 1000
KKLLEEAKKS VKAYLDCVSQ AKNEAEKKEC EKLLTPEAKK LLEQQALDCL
1010 1020 1030 1040 1050
KNAKTEADKK RCVKDLPKDL QKKVLAKESV KAYLDCVSQA KNEAEKKECE
1060 1070 1080 1090 1100
KLLTPEARKL LEEAKESLKA YKDCLSQARN EEERRACEKL LTPEARKLLE
1110 1120 1130 1140 1150
QEVKKSVKAY LDCVSRARNE KEKQECEKLL TPEARKFLAK QVLNCLEKAG
1160 1170 1180 1190 1200
NEEERKACLK NLPKDLQENV LAKESLKAYK DCLSQARNEE ERRACEKLLT
1210 1220 1230 1240 1250
PEARKLLEQE VKKSVKAYLD CVSRARNEKE KQECEKLLTP EARKFLAKQV
1260 1270 1280 1290 1300
LNCLEKAGNE EERKACLKNL PKDLQENVLA KESLKAYKDC LSQARNEEER
1310 1320 1330 1340 1350
RACEKLLTPE ARKLLEQEVK KSVKAYLDCV SRARNEKEKQ ECEKLLTPEA
1360 1370 1380 1390 1400
RKFLAKELQQ KDKAIKDCLK NADPNDRAAI MKCLDGLSDE EKLKYLQEAR
1410 1420 1430 1440 1450
EKAVADCLAM AKTDEEKRKC QNLYSDLIQE IQNKRTQSKQ NQLSKTERLH
1460 1470 1480 1490 1500
QASECLDNLD DPTDQQAIEQ CLEGLSDSER ALILGIKRQA DEVDLIYSEL
1510 1520 1530 1540 1550
RNRKTFDNMA AKGYPLLPMD FKNGGDIATI NATNVDADKI ASDNPIYASI
1560 1570 1580 1590 1600
EPDITKQYET EKTIKDKNLE AKLAKALGGN KKDDDKEKSE KSTAKAKAES
1610 1620 1630 1640 1650
NKIDKDVAET AKNISEIALK NKKEKSGDFV DENGNPIDDK KKEEKQDETS
1660 1670 1680 1690 1700
PVKQAFIGKS DPTFVLAQYT PIEITLTSKV DATLTGIVSG VVAKDVWNMN
1710 1720 1730 1740 1750
GTMILLDKGT KVYGNYQSVK GGTPIMTRLM IVFTKAITPD GVIIPLANAQ
1760 1770 1780 1790 1800
AAGMLGEAGV DGYVNNHFMK RIGFAVIASV VNSFLQTAPI IALDKLIGLG
1810 1820 1830 1840 1850
KGRSERTPEF NYALGQAING SMQSSAQMSN QILGQLMNIP PSFYKNEGDS
1860 1870 1880 1890 1900
IKILTMDDID FSGVYDVKIT NKSVVDEIIK QSTKTLSREH EEITTSPKGG

N
Length:1,901
Mass (Da):216,189
Last modified:December 16, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF37D4509D5C37966
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP001217 Genomic DNA Translation: ACJ07688.1

NCBI Reference Sequences

More...
RefSeqi
WP_001001462.1, NC_011498.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACJ07688; ACJ07688; HPP12_0534

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hpp:HPP12_0534

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001217 Genomic DNA Translation: ACJ07688.1
RefSeqiWP_001001462.1, NC_011498.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiACJ07688; ACJ07688; HPP12_0534
KEGGihpp:HPP12_0534

Phylogenomic databases

HOGENOMiCLU_236752_0_0_7
KOiK12092
OMAiYKDCVSR
OrthoDBi3686at2

Enzyme and pathway databases

BioCyciHPYL570508:G1GU0-567-MONOMER

Family and domain databases

Gene3Di2.40.128.260, 1 hit
InterProiView protein in InterPro
IPR029285 CagY_I
IPR010853 CagY_M
IPR005498 T4SS_VirB10/TraB/TrbI
IPR042217 T4SS_VirB10/TrbI
PfamiView protein in Pfam
PF14585 CagY_I, 2 hits
PF07337 CagY_M, 30 hits
PF03743 TrbI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB6JLB0_HELP2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B6JLB0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: February 26, 2020
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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