Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kynureninase

Gene

kynU

Organism
Rhodospirillum centenum (strain ATCC 51521 / SW)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (kynU)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (kynU)
  3. no protein annotated in this organism
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei99Pyridoxal phosphateUniRule annotation1
Binding sitei168Pyridoxal phosphateUniRule annotation1
Binding sitei197Pyridoxal phosphateUniRule annotation1
Binding sitei200Pyridoxal phosphateUniRule annotation1
Binding sitei222Pyridoxal phosphateUniRule annotation1
Binding sitei252Pyridoxal phosphateUniRule annotation1
Binding sitei278Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciRCEN414684:G1G8I-2656-MONOMER
UniPathwayi
UPA00253;UER00329

UPA00334;UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotationImported
Ordered Locus Names:RC1_2772Imported
OrganismiRhodospirillum centenum (strain ATCC 51521 / SW)Imported
Taxonomic identifieri414684 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeRhodospirillum
Proteomesi
  • UP000001591 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi414684.RC1_2772

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 317Aminotran_5InterPro annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 129Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKY Bacteria
COG3844 LUCA
HOGENOMiHOG000242437
KOiK01556
OMAiVCSLHAS
OrthoDBiPOG091H0D63

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

B6IV21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLGRADLEA LDAADPLAPF RDEFALPEGV LYLDGNSLGA LPRATPARLA
60 70 80 90 100
RLVQEEWGRD LIRSWNTAGW IDLPRRVGEA IAPVVGAGPG QVIAADSTSV
110 120 130 140 150
NLFKLAAAAV GMRPGRRVIL SEPGNFPTDL YVLQGLAELL GDRVELVLAE
160 170 180 190 200
RHELADALDG DVALLLLTHV HYKTGRVHDL PGLTAAAHAA GALTLWDLSH
210 220 230 240 250
SAGALEVGLD AAGADFAVGC GYKYLNGGPG APAWLYVAQR HQDQVRPPLA
260 270 280 290 300
GWMGHAAPFA FEDRFRPADG MARQLCGTPG ILGMAALEEG VRIVARADRA
310 320 330 340 350
RLREKSRRMG DLFLALVAEQ CGPDTFALAC PADGAERGSQ VSLSHPEGYA
360 370 380 390 400
IIQALIARGV IGDFRAPDIL RFGFAPLYLR YTDIWDAVVH LAAVMRDGEW
410
QADRFRQRAA VT
Length:412
Mass (Da):44,151
Last modified:December 16, 2008 - v1
Checksum:iBB5B5D213F424173
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000613 Genomic DNA Translation: ACJ00145.1
RefSeqiWP_012567925.1, NC_011420.2

Genome annotation databases

EnsemblBacteriaiACJ00145; ACJ00145; RC1_2772
KEGGirce:RC1_2772

Similar proteinsi

Entry informationi

Entry nameiB6IV21_RHOCS
AccessioniPrimary (citable) accession number: B6IV21
Entry historyiIntegrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again