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Entry version 80 (11 Dec 2019)
Sequence version 1 (16 Dec 2008)
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Protein
Submitted name:

Frem2a

Gene

frem2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Frem2aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:frem2aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-081119-3 frem2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B6IDE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000076856 Expressed in 16 organ(s), highest expression level in trunk

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2984 – 3013DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2984 – 3001PolyampholyteSequence analysisAdd BLAST18

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1306 Eukaryota
KOG3597 Eukaryota
ENOG410Z1JJ LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007464

KEGG Orthology (KO)

More...
KOi
K23380

Database of Orthologous Groups

More...
OrthoDBi
13258at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2030, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR039005 CSPG_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03160 Calx-beta, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00237 Calx_beta, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141072 SSF141072, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51854 CSPG, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B6IDE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELHRFLLLL LSLTGSSMSA LETHGLSYAS KPELSEDAIL VANNGIHVPF
60 70 80 90 100
GRSVYIDPIN DLVIELQPGD RCTITVLDND PLSQRPGHVS PKKFPCEFGP
110 120 130 140 150
NDVRYSHFGS RSPAGDRVKL QLRYDTQTET IIIPFMLEVE VVFTQLEVVT
160 170 180 190 200
KNMPLVVDKL HGTSNPINKK ILDFTYEKDS EQCEVTSLAA SSVLPKYGKV
210 220 230 240 250
VDDKKLDKMM SCELFLKSNI RYEHTSSHKS PNKDYIPMVV ELRNKENNLL
260 270 280 290 300
KQEFFHVMIR IKEGEENTPP RPSFVAMMMM EVDQFVMTAL TPDMLAAEDT
310 320 330 340 350
ESNSDDLIFN ITSPLSIEEG YIVSTDDRNL PITSFYQKDL KDLKIAYKPP
360 370 380 390 400
SLDSDTERIF QIEFEVIDPD GGISDPFAFM IVVKPMNTLA PIVTKNSGQL
410 420 430 440 450
LYEGQSRSLF TQNNLEISDE DNLDSVRITV VDGLRHGVLT VLGSNRKYFS
460 470 480 490 500
PADLEVGIVV YQHDGSDTYS DNIIFRMTDG KNEVEFLFPI TIVPTDDEPP
510 520 530 540 550
IINANTGLIL FKNQMVPISQ LMLSAADIDS EDSIIKFTIE PPFSAIGEVV
560 570 580 590 600
LRQSEAPEDP SSWKFNADDG VYEKVVTEWL QKDITNEKLF YRHTGPHITE
610 620 630 640 650
TVTDQFVFKV KDDADPPNQS SENNFIIKIL PIDDIPPVLF PGTTLQMTVH
660 670 680 690 700
EYQLTHLSKN VLRYTDLDSE DRDLKYTITQ APTDMDENNP VKFGSIVLTD
710 720 730 740 750
SPDTDVTEFT QAQINHHKIS YNPPDLELGI IPHVVQFHFT VEDTAGNGAD
760 770 780 790 800
GVFTIFLQPV NNKPPQITNS GFTVLERGVH VITSAELDAN DLDTDIKLIS
810 820 830 840 850
FTLSQTPLHG HLQHTFTDLK KGSHFNLMDI SDGQVSYVHN GDETTSDSFK
860 870 880 890 900
LDVSDGVHVV TITVKVTVKL IDDETPTLSL TKGTFGSRLD VLENGATEIT
910 920 930 940 950
PNVIQGKDED TDDLQLTFIV EEAPKFGEIL VNGVSSSRFT QADIISGLVV
960 970 980 990 1000
YAHTSGEIGL TSIEDFFSLT LSDMSDEWNV GGNRVHGVRV HVTILPVDNQ
1010 1020 1030 1040 1050
TPLVTVGPTF NVFEADKNII GSHQIKVEDA DTPNEDILCT IIVQPTSGYV
1060 1070 1080 1090 1100
ENISPAPGSE KSRAGTAVSA FTISDVNEGH IYYVQSIHKG VEPVEDRFTF
1110 1120 1130 1140 1150
RCSDGVNFSE RQFFPIVIIP TNDEKPEIFM REVVVMEGMN VIIDTPLLNG
1160 1170 1180 1190 1200
VDADVPAQEL MFIITKLPNH GFILNQLASG SVPVTNFTLE QIKEASSIIY
1210 1220 1230 1240 1250
EHDDSETTED KFDVLLTDGK HKAEGTVMIM IIPVDDETPR LAINDGLEIE
1260 1270 1280 1290 1300
IGETKEINAK VLKATDLDSD DESLTFIIRY GPAQGLLYRK SAGSVEKRSA
1310 1320 1330 1340 1350
GSTENITVGM NFTQNEVNRG LILYTHNGQE GMRDLVKFDV TDGINPLIDR
1360 1370 1380 1390 1400
YFYITVGSID MVFPDVISKG VSLKEGGKVT LTTNLLSTSD LNSPDENLVF
1410 1420 1430 1440 1450
TITRAPVRGH LESTDTPGMP IVSFTQLQLA GSKIYYIHTA DDEVKMDSFE
1460 1470 1480 1490 1500
FEVTDGYNPV FRTFRVSIVD VDNKKPVLTI HDLLVTEGQT KLITPFELTV
1510 1520 1530 1540 1550
EDQDTAEHLL KFKVSQLPIH GKLLFNNSQP LTSFTKQDLN ENMISYKHDG
1560 1570 1580 1590 1600
TESKKDSFSF TVTDGTHSDF FVFPDTIFET QRPQTMKINI VSVDNGVPQI
1610 1620 1630 1640 1650
EVNKGAPTLK VLFAGHLGYQ MTSKVLKAVD RDSNPEALIF HITTQPEHGY
1660 1670 1680 1690 1700
LISLDRGTEN DSINTFTQAD INDLKICYIL KDENNATSDV FSFTVEDNGG
1710 1720 1730 1740 1750
NKLKNQPFHL NWSWISLEKP NYVVDEHDKV LEVTLRRRGF LGETSFVGIG
1760 1770 1780 1790 1800
TLDGSAEKEK DFLGKSQKQV QFNPGQTTAS WKVRVLSDGK YEQSETFQIV
1810 1820 1830 1840 1850
LTEPVMGVLE APAVATVEIV DPGDESMVFF PQAGFAVEED IGELLVPVRR
1860 1870 1880 1890 1900
TGDVSQELMV VCHTQQDSAT GTVPTSVLSY SDYISRPEEQ VSILRFDKDE
1910 1920 1930 1940 1950
TEKHCRVVII DDSLYESEES FNVTLSMPIG GRLGPEYPTV NIRILPDQDD
1960 1970 1980 1990 2000
APVFYFGSQE YHVDESDGHV EVRVWRTGTD LSKTATVTVR SRKTDPVSAE
2010 2020 2030 2040 2050
AGVDYVGISR NLDFAPGVSM QTVRVTVLDD LGQPVLEGTE RFELVLRMPS
2060 2070 2080 2090 2100
NGILGEPAKV TVFINDSISD LPKVQFKQAV VTVEESEGHV TVMVHRSGDI
2110 2120 2130 2140 2150
KHKSSVRCYT RQGSAQVVYD FEERPNTDAS IVTFLPGEVD KPCVLKLVDD
2160 2170 2180 2190 2200
SIHEEEEELR LVLGNAKSDS PYGASIGNQN ETLIKIKDNA DKSIIKFAET
2210 2220 2230 2240 2250
KFSVSEPKES GQVTLVKIPI RRTGDSSKVS LVRVHTKDGS AISGEDYHPI
2260 2270 2280 2290 2300
SLDVEFKAEE IEHVVEVEVL FDGIREMREA FTVHLKPDEN MIAEIQMTKA
2310 2320 2330 2340 2350
IVYIEETNSM ADVTFPSLPH IVSLLHYDNI RTSKQSAHPP AGYPVVCVTA
2360 2370 2380 2390 2400
CNPKYPDYDK TGSICISERI NNTLTRYRWL ISAPSGPDGV TSPMREADFD
2410 2420 2430 2440 2450
TFFTSSKMIT LDSIYFQAGS RVQCAARAVN SNGDEGLELS SPIVSISMEE
2460 2470 2480 2490 2500
GMCQPRKLGT VGAEPFSAKL RYTGAEDLEY ANLIKLTVTM PHIDGMLPVV
2510 2520 2530 2540 2550
STRALSNFDL TLSPDGTRVG NHRCSNLLDF NEVSTRHGFL TKATRNIQSV
2560 2570 2580 2590 2600
GETLPYQYSP VLRGQGTLRF YRNLNLEACL WEFVSYYDMS ELLTDCGGTI
2610 2620 2630 2640 2650
GTDGQVLNLV QSYVTLRVPL HVSYVFHSPV GAGGWQHFDL HSELRLTFVY
2660 2670 2680 2690 2700
DTAILWKDGV GSQTQADLQG NLGALYPTSM RINEQGRLVV NFRTEARFRG
2710 2720 2730 2740 2750
LFVVGHPAST VSTVMSADHP GLTFNLTLVR TEPTYSQPVQ QWMFISDFAV
2760 2770 2780 2790 2800
RDYSGTYTVS LIPCTAALNV EFTVPPVCNP REAITFDLDI RFQQVSDPVA
2810 2820 2830 2840 2850
VEFSLNTQMF LLSKKVLWLS DGSMGFGQES DAAFSEGDVI YGRVMVDPVQ
2860 2870 2880 2890 2900
NLGDSFYCNI EKVYLCTGAD GYVPKYNPSK SEFGCLADSP SLLYQFKIID
2910 2920 2930 2940 2950
KAQPETQARS FGNVDFNALL AVDDPSALSL VKQPGSDGFR LHSTPLFQVA
2960 2970 2980 2990 3000
VGREWFIHTI YTVRSKDNAK RGIGKRSVEQ HLITSGDLKE SRRRSRRSNR
3010 3020 3030 3040 3050
DVPTLAEQIG PENNRGTNIM HIALDRSRRT ASEEELFAEG LSPRGLSGRQ
3060 3070 3080 3090 3100
AEEEAVTVAG ALVGLLLTVL VFVALALVVR SRRTPAKKAP RVSPSLQPVI
3110
VRSSLDNGDS SEV
Length:3,113
Mass (Da):345,697
Last modified:December 16, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE65A4515CCCEDDD9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BK006471 mRNA Translation: DAA06344.1

NCBI Reference Sequences

More...
RefSeqi
NP_001131129.1, NM_001137657.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
555681

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:555681

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK006471 mRNA Translation: DAA06344.1
RefSeqiNP_001131129.1, NM_001137657.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiB6IDE6

Genome annotation databases

GeneIDi555681
KEGGidre:555681

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
555681
ZFINiZDB-GENE-081119-3 frem2a

Phylogenomic databases

eggNOGiKOG1306 Eukaryota
KOG3597 Eukaryota
ENOG410Z1JJ LUCA
HOGENOMiHOG000007464
KOiK23380
OrthoDBi13258at2759

Gene expression databases

BgeeiENSDARG00000076856 Expressed in 16 organ(s), highest expression level in trunk

Family and domain databases

Gene3Di2.60.40.2030, 5 hits
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR039005 CSPG_rpt
PfamiView protein in Pfam
PF03160 Calx-beta, 5 hits
SMARTiView protein in SMART
SM00237 Calx_beta, 5 hits
SUPFAMiSSF141072 SSF141072, 5 hits
PROSITEiView protein in PROSITE
PS51854 CSPG, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB6IDE6_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B6IDE6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 16, 2008
Last sequence update: December 16, 2008
Last modified: December 11, 2019
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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