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Protein

Argininosuccinate synthase

Gene

argG

Organism
Escherichia coli (strain SE11)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei99CitrullineUniRule annotation1
Binding sitei129ATP; via amide nitrogenUniRule annotation1
Binding sitei131AspartateUniRule annotation1
Binding sitei131ATPUniRule annotation1
Binding sitei135AspartateUniRule annotation1
Binding sitei135CitrullineUniRule annotation1
Binding sitei136AspartateUniRule annotation1
Binding sitei136ATPUniRule annotation1
Binding sitei139CitrullineUniRule annotation1
Binding sitei192CitrullineUniRule annotation1
Binding sitei194ATPUniRule annotation1
Binding sitei201CitrullineUniRule annotation1
Binding sitei203CitrullineUniRule annotation1
Binding sitei280CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 25ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:ECSE_3457
OrganismiEscherichia coli (strain SE11)
Taxonomic identifieri409438 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000008199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001297511 – 447Argininosuccinate synthaseAdd BLAST447

Proteomic databases

PRIDEiB6I1P6

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB6I1P6
SMRiB6I1P6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230094
KOiK01940
OMAiGVGRIDM

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di1.10.287.400, 1 hit
3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00581 Arg_succ_synth_type2, 1 hit
InterProiView protein in InterPro
IPR023437 Arg_succ_synth_type2_subfam
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR024073 AS_multimer_C_tail
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

B6I1P6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTILKHLPV GQRIGIAFSG GLDTSAALLW MRQKGAVPYA YTANLGQPDE
60 70 80 90 100
EDYDAIPRRA MEYGAENARL IDCRKQLVAE GIAAIQCGAF HNTTGGLTYF
110 120 130 140 150
NTTPLGRAVT GTMLVAAMKE DGVNIWGDGS TYKGNDIERF YRYGLLTNAE
160 170 180 190 200
LQIYKPWLDT DFIDELGGRH EMSEFMIACG FDYKMSVEKA YSTDSNMLGA
210 220 230 240 250
THEAKDLEYL NSSVKIVNPI MGVKFWDESV KIPAEEVTVR FEQGHPVALN
260 270 280 290 300
GKTFSDDVEM MLEANRIGGR HGLGMSDQIE NRIIEAKSRG IYEAPGMALL
310 320 330 340 350
HIAYERLLTG IHNEDTIEQY HAHGRQLGRL LYQGRWFDSQ ALMLRDSLQR
360 370 380 390 400
WVASQITGEV TLELRRGNDY SILNTVSENL TYKPERLTME KGDSVFSPDD
410 420 430 440
RIGQLTMRNL DITDTREKLF GYAKTGLLSS SATSGVPQVE NMENKGQ
Length:447
Mass (Da):49,946
Last modified:December 16, 2008 - v1
Checksum:iD5E7E51BD06FB812
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009240 Genomic DNA Translation: BAG78981.1
RefSeqiWP_000207685.1, NC_011415.1

Genome annotation databases

EnsemblBacteriaiBAG78981; BAG78981; ECSE_3457
KEGGiecy:ECSE_3457

Similar proteinsi

Entry informationi

Entry nameiASSY_ECOSE
AccessioniPrimary (citable) accession number: B6I1P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 16, 2008
Last modified: February 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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