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UniProtKB - B6DVZ3 (B6DVZ3_9POLY)

Entry version 48 (29 Sep 2021)
Sequence version 1 (25 Nov 2008)
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Protein
Submitted name:

Capsid protein

Gene

VP1

Organism
Merkel cell polyomavirus
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interactionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Capsid proteinImported
Submitted name:
Capsid protein VP1Imported
Submitted name:
Major capsid proteinImported
Submitted name:
Major capsid protein VP1Imported
Submitted name:
VP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMerkel cell polyomavirusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri493803 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Monodnaviria › Shotokuvirae › Cossaviricota › Papovaviricetes › Sepolyvirales › Polyomaviridae › Alphapolyomavirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

VirionARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Keywords - Developmental stagei

Late proteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimer; disulfide-linked. The virus capsid is composed of 72 icosahedral units, each one composed of five disulfide-linked copies of VP1.

Interacts with minor capsid proteins VP2 and VP3.

ARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni392 – 423DisorderedSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polyomaviruses coat protein VP1 family.ARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.175.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000662, Capsid_VP1_Polyomavir
IPR011222, dsDNA_vir_gr_I_capsid
IPR036931, Polyomavir_VP1_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00718, Polyoma_coat, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF88648, SSF88648, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B6DVZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKRKASST CKTPKRQCIP KPGCCPNVAS VPKLLVKGGV EVLSVVTGED 
        60         70         80         90        100
SITQIELYLN PRMGVNSPDL PTTSNWYTYT YDLQPKGSSP DQPIKENLPA 
       110        120        130        140        150
YSVARVSLPM LNEDITCDTL QMWEAISVKT EVVGISSLIN VHYWDMKRVH 
       160        170        180        190        200
DYGAGIPVSG VNYHMFAIGG EPLDLQGLVL DYQTEYPKTT NGGPITIETV 
       210        220        230        240        250
LGRKMTPKNQ GLDPQAKAKL DKDGNYPIEV WCPDPSKNEN SRYYGSIQTG 
       260        270        280        290        300
SQTPTVLQFS NTLTTVLLDE NGVGPLCKGD GLFISCADIV GFLFKTSGKM 
       310        320        330        340        350
ALHGLPRYFN VTLRKRWVKN PYPVVNLINS LFSNLMPKVS GQPMEGKDNQ 
       360        370        380        390        400
VEEVRIYEGS EQLPGDPDIV RFLDKFGQEK TVYPKPSVAP AAVTFQSNQQ 
       410        420 
DKGKAPLKGP QKASQKESQT QEL
Length:423
Mass (Da):46,563
Last modified:November 25, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE4B2F868BD704FC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FJ173815 Genomic DNA Translation: ACI25319.1
HM011543 Genomic DNA Translation: ADE45363.1
HM011546 Genomic DNA Translation: ADE45375.1
HM011547 Genomic DNA Translation: ADE45379.1
HM011549 Genomic DNA Translation: ADE45387.1
HM011550 Genomic DNA Translation: ADE45391.1
HM011551 Genomic DNA Translation: ADE45395.1
HM011553 Genomic DNA Translation: ADE45403.1
HM011554 Genomic DNA Translation: ADE45407.1
HM011555 Genomic DNA Translation: ADE45411.1
HM011556 Genomic DNA Translation: ADE45415.1
HM011557 Genomic DNA Translation: ADE45419.1
JF813002 Genomic DNA Translation: AEM01095.1
JF813003 Genomic DNA Translation: AEM01098.1
JN383838 Genomic DNA Translation: AFC36077.1
JN383840 Genomic DNA Translation: AFC36088.1
JN383841 Genomic DNA Translation: AFC36093.1
JQ479316 Genomic DNA Translation: AFM84440.1
JQ479317 Genomic DNA Translation: AFM84445.1
KC202810 Genomic DNA Translation: AGA03918.1
KJ022619 Genomic DNA Translation: AHN13648.1
KJ128379 Genomic DNA Translation: AHN49701.1
KJ128380 Genomic DNA Translation: AHN49705.1
KJ128381 Genomic DNA Translation: AHN49709.1
KF266963 Genomic DNA Translation: AHW79940.1
KP293741 Genomic DNA Translation: AKK25202.1
KX781279 Genomic DNA Translation: AQM73644.1
MG241581 Genomic DNA Translation: AWG42121.1
MG241582 Genomic DNA Translation: AWG42124.1
MG241592 Genomic DNA Translation: AWG42134.1
MG241598 Genomic DNA Translation: AWG42140.1
AB844262 Genomic DNA Translation: BAN78699.1
LC097008 Genomic DNA Translation: BAV01229.1
FM864207 Genomic DNA Translation: CAR95364.1
FM864210 Genomic DNA Translation: CAR95367.1
FM864211 Genomic DNA Translation: CAR95368.1
FM864212 Genomic DNA Translation: CAR95369.1

NCBI Reference Sequences

More...RefSeqi		YP_009111420.1, NC_010277.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10987416

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:10987416

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ173815 Genomic DNA Translation: ACI25319.1
HM011543 Genomic DNA Translation: ADE45363.1
HM011546 Genomic DNA Translation: ADE45375.1
HM011547 Genomic DNA Translation: ADE45379.1
HM011549 Genomic DNA Translation: ADE45387.1
HM011550 Genomic DNA Translation: ADE45391.1
HM011551 Genomic DNA Translation: ADE45395.1
HM011553 Genomic DNA Translation: ADE45403.1
HM011554 Genomic DNA Translation: ADE45407.1
HM011555 Genomic DNA Translation: ADE45411.1
HM011556 Genomic DNA Translation: ADE45415.1
HM011557 Genomic DNA Translation: ADE45419.1
JF813002 Genomic DNA Translation: AEM01095.1
JF813003 Genomic DNA Translation: AEM01098.1
JN383838 Genomic DNA Translation: AFC36077.1
JN383840 Genomic DNA Translation: AFC36088.1
JN383841 Genomic DNA Translation: AFC36093.1
JQ479316 Genomic DNA Translation: AFM84440.1
JQ479317 Genomic DNA Translation: AFM84445.1
KC202810 Genomic DNA Translation: AGA03918.1
KJ022619 Genomic DNA Translation: AHN13648.1
KJ128379 Genomic DNA Translation: AHN49701.1
KJ128380 Genomic DNA Translation: AHN49705.1
KJ128381 Genomic DNA Translation: AHN49709.1
KF266963 Genomic DNA Translation: AHW79940.1
KP293741 Genomic DNA Translation: AKK25202.1
KX781279 Genomic DNA Translation: AQM73644.1
MG241581 Genomic DNA Translation: AWG42121.1
MG241582 Genomic DNA Translation: AWG42124.1
MG241592 Genomic DNA Translation: AWG42134.1
MG241598 Genomic DNA Translation: AWG42140.1
AB844262 Genomic DNA Translation: BAN78699.1
LC097008 Genomic DNA Translation: BAV01229.1
FM864207 Genomic DNA Translation: CAR95364.1
FM864210 Genomic DNA Translation: CAR95367.1
FM864211 Genomic DNA Translation: CAR95368.1
FM864212 Genomic DNA Translation: CAR95369.1
RefSeqiYP_009111420.1, NC_010277.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi10987416
KEGGivg:10987416

Family and domain databases

Gene3Di2.60.175.10, 1 hit
InterProiView protein in InterPro
IPR000662, Capsid_VP1_Polyomavir
IPR011222, dsDNA_vir_gr_I_capsid
IPR036931, Polyomavir_VP1_sf
PfamiView protein in Pfam
PF00718, Polyoma_coat, 1 hit
SUPFAMiSSF88648, SSF88648, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB6DVZ3_9POLY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B6DVZ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: September 29, 2021
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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