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Protein

Ferritin

Gene

FTN

Organism
Pseudo-nitzschia multiseries
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.UniRule annotation

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron 1Combined sources1
Metal bindingi64Iron 2Combined sources1
Metal bindingi64Iron 3Combined sources1
Metal bindingi65Iron 1Combined sources1
Metal bindingi68Iron 2Combined sources1
Metal bindingi77Iron 4Combined sources1
Metal bindingi77Iron 5Combined sources1
Metal bindingi77Zinc 1Combined sources1
Metal bindingi92Iron 6Combined sources1
Metal bindingi97Iron 6Combined sources1
Metal bindingi102Iron 7Combined sources1
Metal bindingi102Iron 8Combined sources1
Metal bindingi106Iron 10Combined sources1
Metal bindingi106Iron 11Combined sources1
Metal bindingi106Iron 7Combined sources1
Metal bindingi106Iron 8Combined sources1
Metal bindingi106Iron 9Combined sources1
Metal bindingi106Zinc 2Combined sources1
Metal bindingi109Iron 10Combined sources1
Metal bindingi109Iron 12Combined sources1
Metal bindingi109Iron 13Combined sources1
Metal bindingi109Iron 9Combined sources1
Metal bindingi109Zinc 2Combined sources1
Metal bindingi110Iron 11Combined sources1
Metal bindingi110Iron 14Combined sources1
Metal bindingi110Iron 15Combined sources1
Metal bindingi110Iron 16Combined sources1
Metal bindingi110Iron 4Combined sources1
Metal bindingi110Iron 5Combined sources1
Metal bindingi110Zinc 1Combined sources1
Metal bindingi110Zinc 3Combined sources1
Metal bindingi110Zinc 4Combined sources1
Metal bindingi113Iron 17; via tele nitrogenCombined sources1
Metal bindingi113Iron 4; via pros nitrogenCombined sources1
Metal bindingi113Zinc 1; via pros nitrogenCombined sources1
Metal bindingi156Iron 11Combined sources1
Metal bindingi156Iron 14Combined sources1
Metal bindingi156Iron 15Combined sources1
Metal bindingi156Iron 16Combined sources1
Metal bindingi156Zinc 3Combined sources1
Metal bindingi156Zinc 4Combined sources1
Metal bindingi159Iron 15Combined sources1
Metal bindingi159Iron 4Combined sources1
Metal bindingi188Iron 17Combined sources1
Metal bindingi189Iron 16Combined sources1
Metal bindingi192Iron 11Combined sources1
Metal bindingi192Iron 17Combined sources1
Metal bindingi192Iron 7Combined sources1
Metal bindingi192Iron 9Combined sources1
Metal bindingi192Zinc 2Combined sources1
Metal bindingi192Zinc 4Combined sources1

GO - Molecular functioni

  • ferric iron binding Source: InterPro
  • ferroxidase activity Source: UniProtKB-EC
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processIron storageUniRule annotation
LigandIron, Metal-bindingUniRule annotationCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
FerritinUniRule annotation (EC:1.16.3.1UniRule annotation)
Gene namesi
Name:FTNImported
OrganismiPseudo-nitzschia multiseriesImported
Taxonomic identifieri37319 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesBacillariophytaBacillariophyceaeBacillariophycidaeBacillarialesBacillariaceaePseudo-nitzschia

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500284193221 – 230FerritinSequence analysisAdd BLAST210

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15743329,EBI-15743329

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-59728N

Structurei

3D structure databases

SMRiB6DMH6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiB6DMH6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 207Ferritin-like diironInterPro annotationAdd BLAST148

Sequence similaritiesi

Belongs to the ferritin family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Fragment.

B6DMH6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSPFFFLSA LALTLRDSSP SFATAFRLAV TRCARQGIHA PSSSSSSSSR
60 70 80 90 100
CLVASASALA GPSEELLDLF NRQVTQEFTA SQVYLSASIW FDQNDWEGMA
110 120 130 140 150
AYMLAESAEE REHGLGFVDF ANKRNIPIEL QAVPAPVSCA EWSSPEDVWQ
160 170 180 190 200
SILELEQANT RSLLNLAEAA STCHDFAVMA FLNPFHLQQV NEEDKIGSIL
210 220 230
AKVTDENRTP GLLRSLDVVS FLGPCLFRSV
Length:230
Mass (Da):25,199
Last modified:November 25, 2008 - v1
Checksum:i56107F9680350575
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei230Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ004953 mRNA Translation: ACI30660.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ004953 mRNA Translation: ACI30660.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E6RX-ray2.40A/B/C/D/E/F63-229[»]
3E6SX-ray1.95A/B/C/D/E/F63-229[»]
4ISMX-ray2.00A/B/C/D/E/F/G/H63-229[»]
4ISPX-ray2.20A/B/C/D/E/F/G/H63-229[»]
4ITTX-ray2.10A/B/C/D/E/F/G/H63-229[»]
4ITWX-ray2.00A/B/C/D/E/F/G/H63-229[»]
4IWJX-ray1.95A/B/C/D/E/F/G/H63-229[»]
4IWKX-ray1.65A/B/C/D/E/F63-229[»]
4IXKX-ray2.10A/B/C/D/E/F/G/H63-229[»]
4ZKHX-ray1.90A/B/C/D/E/F/G/H63-230[»]
4ZKWX-ray1.80A/B/C/D/E/F/G/H63-230[»]
4ZKXX-ray1.80A/B/C/D/E/F/G/H63-230[»]
4ZL5X-ray1.85A/B/C/D/E/F63-230[»]
4ZL6X-ray1.90A/B/C/D/E/F63-230[»]
4ZLWX-ray2.00A/B/C/D/E/F/G/H63-229[»]
4ZMCX-ray1.90A/B/C/D/E/F/G/H63-229[»]
SMRiB6DMH6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59728N

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiB6DMH6

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS50905 FERRITIN_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB6DMH6_9STRA
AccessioniPrimary (citable) accession number: B6DMH6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: October 10, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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