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Entry version 63 (02 Dec 2020)
Sequence version 1 (25 Nov 2008)
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Protein

Ferritin

Gene

FTN

Organism
Pseudo-nitzschia multiseries
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi64Iron 1Combined sources1
Metal bindingi64Iron 2Combined sources1
Metal bindingi64Iron 3Combined sources1
Metal bindingi65Iron 1Combined sources1
Metal bindingi68Iron 2Combined sources1
Metal bindingi77Iron 4Combined sources1
Metal bindingi77Iron 5Combined sources1
Metal bindingi77Zinc 1Combined sources1
Metal bindingi92Iron 6Combined sources1
Metal bindingi97Iron 6Combined sources1
Metal bindingi102Iron 7Combined sources1
Metal bindingi102Iron 8Combined sources1
Metal bindingi106Iron 10Combined sources1
Metal bindingi106Iron 11Combined sources1
Metal bindingi106Iron 7Combined sources1
Metal bindingi106Iron 8Combined sources1
Metal bindingi106Iron 9Combined sources1
Metal bindingi106Zinc 2Combined sources1
Metal bindingi109Iron 10Combined sources1
Metal bindingi109Iron 12Combined sources1
Metal bindingi109Iron 13Combined sources1
Metal bindingi109Iron 9Combined sources1
Metal bindingi109Zinc 2Combined sources1
Metal bindingi110Iron 11Combined sources1
Metal bindingi110Iron 14Combined sources1
Metal bindingi110Iron 15Combined sources1
Metal bindingi110Iron 16Combined sources1
Metal bindingi110Iron 4Combined sources1
Metal bindingi110Iron 5Combined sources1
Metal bindingi110Zinc 1Combined sources1
Metal bindingi110Zinc 3Combined sources1
Metal bindingi110Zinc 4Combined sources1
Metal bindingi113Iron 17; via tele nitrogenCombined sources1
Metal bindingi113Iron 4; via pros nitrogenCombined sources1
Metal bindingi113Zinc 1; via pros nitrogenCombined sources1
Metal bindingi156Iron 11Combined sources1
Metal bindingi156Iron 14Combined sources1
Metal bindingi156Iron 15Combined sources1
Metal bindingi156Iron 16Combined sources1
Metal bindingi156Zinc 3Combined sources1
Metal bindingi156Zinc 4Combined sources1
Metal bindingi159Iron 15Combined sources1
Metal bindingi159Iron 4Combined sources1
Metal bindingi188Iron 17Combined sources1
Metal bindingi189Iron 16Combined sources1
Metal bindingi192Iron 11Combined sources1
Metal bindingi192Iron 17Combined sources1
Metal bindingi192Iron 7Combined sources1
Metal bindingi192Iron 9Combined sources1
Metal bindingi192Zinc 2Combined sources1
Metal bindingi192Zinc 4Combined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processIron storageUniRule annotationARBA annotation
LigandIron, Metal-bindingUniRule annotationCombined sources, ZincCombined sources

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FerritinUniRule annotation (EC:1.16.3.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FTNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudo-nitzschia multiseriesImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri37319 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarStramenopilesOchrophytaBacillariophytaBacillariophyceaeBacillariophycidaeBacillarialesBacillariaceaePseudo-nitzschia

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500284193221 – 230FerritinSequence analysisAdd BLAST210

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

B6DMH6
With#Exp.IntAct
itself2EBI-15743329,EBI-15743329

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-59728N

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
B6DMH6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
B6DMH6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 207Ferritin-like diironInterPro annotationAdd BLAST148

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ferritin family.UniRule annotationARBA annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01055, Nonheme_Ferritin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1260.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001519, Ferritin
IPR012347, Ferritin-like
IPR009040, Ferritin-like_diiron
IPR009078, Ferritin-like_SF
IPR008331, Ferritin_DPS_dom
IPR041719, Ferritin_prok

The PANTHER Classification System

More...
PANTHERi
PTHR11431, PTHR11431, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00210, Ferritin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47240, SSF47240, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50905, FERRITIN_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

B6DMH6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSPFFFLSA LALTLRDSSP SFATAFRLAV TRCARQGIHA PSSSSSSSSR
60 70 80 90 100
CLVASASALA GPSEELLDLF NRQVTQEFTA SQVYLSASIW FDQNDWEGMA
110 120 130 140 150
AYMLAESAEE REHGLGFVDF ANKRNIPIEL QAVPAPVSCA EWSSPEDVWQ
160 170 180 190 200
SILELEQANT RSLLNLAEAA STCHDFAVMA FLNPFHLQQV NEEDKIGSIL
210 220 230
AKVTDENRTP GLLRSLDVVS FLGPCLFRSV
Length:230
Mass (Da):25,199
Last modified:November 25, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56107F9680350575
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei230Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ004953 mRNA Translation: ACI30660.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ004953 mRNA Translation: ACI30660.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E6RX-ray2.40A/B/C/D/E/F63-229[»]
3E6SX-ray1.95A/B/C/D/E/F63-229[»]
4ISMX-ray2.00A/B/C/D/E/F/G/H63-229[»]
4ISPX-ray2.20A/B/C/D/E/F/G/H63-229[»]
4ITTX-ray2.10A/B/C/D/E/F/G/H63-229[»]
4ITWX-ray2.00A/B/C/D/E/F/G/H63-229[»]
4IWJX-ray1.95A/B/C/D/E/F/G/H63-229[»]
4IWKX-ray1.65A/B/C/D/E/F63-229[»]
4IXKX-ray2.10A/B/C/D/E/F/G/H63-229[»]
4ZKHX-ray1.90A/B/C/D/E/F/G/H63-230[»]
4ZKWX-ray1.80A/B/C/D/E/F/G/H63-230[»]
4ZKXX-ray1.80A/B/C/D/E/F/G/H63-230[»]
4ZL5X-ray1.85A/B/C/D/E/F63-230[»]
4ZL6X-ray1.90A/B/C/D/E/F63-230[»]
4ZLWX-ray2.00A/B/C/D/E/F/G/H63-229[»]
4ZMCX-ray1.90A/B/C/D/E/F/G/H63-229[»]
SMRiB6DMH6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-59728N

Miscellaneous databases

EvolutionaryTraceiB6DMH6

Family and domain databases

CDDicd01055, Nonheme_Ferritin, 1 hit
Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519, Ferritin
IPR012347, Ferritin-like
IPR009040, Ferritin-like_diiron
IPR009078, Ferritin-like_SF
IPR008331, Ferritin_DPS_dom
IPR041719, Ferritin_prok
PANTHERiPTHR11431, PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210, Ferritin, 1 hit
SUPFAMiSSF47240, SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS50905, FERRITIN_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB6DMH6_9STRA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B6DMH6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: December 2, 2020
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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