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Protein

Toll-like receptor

Gene
N/A
Organism
Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorUniRule annotationSAAS annotationImported
Biological processImmunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptorUniRule annotation
OrganismiCercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)Imported
Taxonomic identifieri9531 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeCercocebus
Proteomesi
  • UP000233060 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei588 – 609HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20UniRule annotationAdd BLAST20
ChainiPRO_501101933821 – 784Toll-like receptorUniRule annotationAdd BLAST764

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB6CJY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini639 – 784TIRInterPro annotationAdd BLAST146

Sequence similaritiesi

Belongs to the Toll-like receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119006
HOVERGENiHBG108574
OrthoDBiEOG091G05L8

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR027185 TLR2
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR24365:SF17 PTHR24365:SF17, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF01463 LRRCT, 1 hit
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 7 hits
SM00082 LRRCT, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 11 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

B6CJY8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHTLWMVWV LGVIISLSKE ESSNQASLSC DHNGICKGSS GSLNSIPSGL
60 70 80 90 100
TEAVKSLDLS NNRITYISNS DLQRCVNLQA LVLTSNGINT IEEDSFSSLG
110 120 130 140 150
RLEHLDLSYN YLSNLSSSWF KPLSSLKFLN LLGNPYKTLG ETSLFSHLTK
160 170 180 190 200
LRILRVGNMD TFTKIQRKDF AGLTFLEELE IDASDLQSYE PKSLKSIQNV
210 220 230 240 250
SHLILHMKQH ILLLEIFVDL TSSVECLELR DTDLDTFHFS ELSTGETNSL
260 270 280 290 300
IKKFTFRKVK ITDESLFQVM KLLSQISGLL ELEFDDCTLN GVGDFRGSDN
310 320 330 340 350
DRVIDPGKVE TLTIRRLHIP RFYLFYDLST LYSLTERIKR ITVENSKVFL
360 370 380 390 400
VPCLLSRHLK SLEYLDLSEN LMVEEYLKNS ACEDAWPSLQ TLILRQNHLA
410 420 430 440 450
SLGKTGETLL TLKNLTNLDI SKNTFHYMPE TCQWPGKMKY LNLSSTRIHS
460 470 480 490 500
VTGCIPKTLE ILDISNNNLN LFSLNLPQLK ELYISRNKLM TLPDASLLPM
510 520 530 540 550
LLVLKISRNT ITTFSKEQLD SFHTLKTLEA GGNNFICSCE FLSFTQEQQA
560 570 580 590 600
LAKVLVDWPA NYLCDSPSHV RGQRVQDVHL SVSECHRAAL VSGMCCALFL
610 620 630 640 650
LILLMGVLCH RFHGLWYMKM MWAWLQAKRK PRKAPNRDIC YDAFVSYSER
660 670 680 690 700
DAYWVENLMV QELENFNPPF KLCLHKRDFI PGKWIIDNII DSIEKSHKTV
710 720 730 740 750
FVLSENFVKS EWCKYELDFS HFRLFDENND AAILVLLEPI EKKAIPQRFC
760 770 780
KLRKIMNTKT YLEWPMDEAR QEGFWVNLRA AIKS
Length:784
Mass (Da):89,972
Last modified:November 25, 2008 - v1
Checksum:iB519C3A617BEFBA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU204932 mRNA Translation: ABY64986.1
RefSeqiNP_001292895.1, NM_001305966.1
XP_011904377.1, XM_012048987.1
XP_011904378.1, XM_012048988.1
XP_011904380.1, XM_012048990.1

Genome annotation databases

EnsembliENSCATT00000026214; ENSCATP00000007629; ENSCATG00000022673
GeneIDi105580685

Similar proteinsi

Entry informationi

Entry nameiB6CJY8_CERAT
AccessioniPrimary (citable) accession number: B6CJY8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: July 18, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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