UniProtKB - B6A8C7 (TARM1_HUMAN)

BLAST

>sp|B6A8C7|TARM1_HUMAN T-cell-interacting, activating receptor on myeloid cells protein 1 OS=Homo sapiens OX=9606 GN=TARM1 PE=1 SV=1
MIPKLLSLLCFRLCVGQGDTRGDGSLPKPSLSAWPSSVVPANSNVTLRCWTPARGVSFVL
RKGGIILESPKPLDSTEGAAEFHLNNLKVRNAGEYTCEYYRKASPHILSQRSDVLLLLVT
GHLSKPFLRTYQRGTVTAGGRVTLQCQKRDQLFVPIMFALLKAGTPSPIQLQSPAGKEID
FSLVDVTAGDAGNYSCMYYQTKSPFWASEPSDQLEILVTVPPGTTSSNYSLGNFVRLGLA
AVIVVIMGAFLVEAWYSRNVSPGESEAFKPE

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History
Entry version 74 (12 Sep 2018)
Sequence version 1 (25 Nov 2008)
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Protein

T-cell-interacting, activating receptor on myeloid cells protein 1

Gene

TARM1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May act as receptor (By similarity). Negatively regulates TCR-mediated CD4⁺ T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface (PubMed:26311901). Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

immunoglobulin receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 26311901

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
innate immune response Source: UniProtKB-KW
negative regulation of CD4-positive, alpha-beta T cell activation
Source: UniProtKB
Inferred from direct assayⁱ
- 26311901
neutrophil degranulation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Adaptive immunity, Immunity, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-cell-interacting, activating receptor on myeloid cells protein 1 Alternative name(s): OSCAR-like transcript-2 protein Short name: OLT-2
Gene namesⁱ	Name:TARM1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000248385.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:37250 TARM1
neXtProtⁱ	NX_B6A8C7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	17 – 236	ExtracellularSequence analysisAdd BLAST	220
Transmembraneⁱ	237 – 257	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	258 – 271	CytoplasmicSequence analysisAdd BLAST	14

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA165394443

PharmGKBⁱ

PA165394443

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 16	Sequence analysisAdd BLAST		16
ChainⁱPRO_0000394231	17 – 271	T-cell-interacting, activating receptor on myeloid cells protein 1Add BLAST		255

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	44	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	49 ↔ 97	PROSITE-ProRule annotation
Disulfide bondⁱ	146 ↔ 196	PROSITE-ProRule annotation

Post-translational modificationⁱ

N-glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	B6A8C7
PRIDEⁱ	B6A8C7
ProteomicsDBⁱ	6241 6242 [B6A8C7-2]

PTM databases

iPTMnetⁱ	B6A8C7
PhosphoSitePlusⁱ	B6A8C7

Expressionⁱ

Tissue specificityⁱ

Expressed in fetal and adult liver, lung, testis, thymus and spleen. Expressed in blood neutrophils.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000248385 Expressed in 9 organ(s), highest expression level in blood
ExpressionAtlasⁱ	B6A8C7 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051022 HPA054401

HPAⁱ

HPA051022
HPA054401

Interactionⁱ

Subunit structureⁱ

Interacts with Fc receptor gamma chain FCER1G.1 Publication

GO - Molecular functionⁱ

immunoglobulin receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 26311901

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B6A8C7
SMRⁱ	B6A8C7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 113	Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST		87
Domainⁱ	126 – 212	Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST		87

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J9W1 Eukaryota ENOG411166F LUCA
HOGENOMⁱ	HOG000234395
HOVERGENⁱ	HBG105594
InParanoidⁱ	B6A8C7
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IK8
PhylomeDBⁱ	B6A8C7
TreeFamⁱ	TF336644

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13895 Ig_2, 2 hits
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: B6A8C7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPKLLSLLC FRLCVGQGDT RGDGSLPKPS LSAWPSSVVP ANSNVTLRCW 
        60         70         80         90        100
TPARGVSFVL RKGGIILESP KPLDSTEGAA EFHLNNLKVR NAGEYTCEYY 
       110        120        130        140        150
RKASPHILSQ RSDVLLLLVT GHLSKPFLRT YQRGTVTAGG RVTLQCQKRD 
       160        170        180        190        200
QLFVPIMFAL LKAGTPSPIQ LQSPAGKEID FSLVDVTAGD AGNYSCMYYQ 
       210        220        230        240        250
TKSPFWASEP SDQLEILVTV PPGTTSSNYS LGNFVRLGLA AVIVVIMGAF 
       260        270 
LVEAWYSRNV SPGESEAFKP E

Note: No experimental confirmation available.

Length:271

Mass (Da):29,474

Last modified:November 25, 2008 - v1

Checksum:ⁱB1E2B17A1C657060

Isoform 2 (identifier: B6A8C7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-12: MIPKLLSLLCFR → MKERKKKERKERKRKKERNG

« Hide

        10         20         30         40         50
MKERKKKERK ERKRKKERNG LCVGQGDTRG DGSLPKPSLS AWPSSVVPAN 
        60         70         80         90        100
SNVTLRCWTP ARGVSFVLRK GGIILESPKP LDSTEGAAEF HLNNLKVRNA 
       110        120        130        140        150
GEYTCEYYRK ASPHILSQRS DVLLLLVTGH LSKPFLRTYQ RGTVTAGGRV 
       160        170        180        190        200
TLQCQKRDQL FVPIMFALLK AGTPSPIQLQ SPAGKEIDFS LVDVTAGDAG 
       210        220        230        240        250
NYSCMYYQTK SPFWASEPSD QLEILVTVPP GTTSSNYSLG NFVRLGLAAV 
       260        270 
IVVIMGAFLV EAWYSRNVSP GESEAFKPE

Note: No experimental confirmation available.

Show »

Length:279

Mass (Da):30,683

Checksum:ⁱ42E4CECB90930F2B

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087X1Q6	A0A087X1Q6_HUMAN		T-cell-interacting,-activating rece... T-cell-interacting,-activating receptor on myeloid cells protein 1	TARM1	279	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_063151	37	S → P. Corresponds to variant dbSNP:rs17305269Ensembl.	1
Natural variantⁱVAR_063152	111	R → H. Corresponds to variant dbSNP:rs80087697Ensembl.	1
Natural variantⁱVAR_063153	258	R → W. Corresponds to variant dbSNP:rs77768804Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_039225	1 – 12	MIPKL…LLCFR → MKERKKKERKERKRKKERNG in isoform 2. 1 PublicationAdd BLAST		12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ479398 mRNA Translation: ABF19808.1 AK301730 mRNA Translation: BAG63196.1 AC012314 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46173.1 [B6A8C7-1] CCDS82395.1 [B6A8C7-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001129158.2, NM_001135686.2 NP_001317579.1, NM_001330650.1
UniGeneⁱ	Hs.694674

Genome annotation databases

Ensemblⁱ	ENST00000432826; ENSP00000439454; ENSG00000248385 ENST00000611088; ENSP00000479824; ENSG00000276145 [B6A8C7-1] ENST00000611419; ENSP00000478234; ENSG00000275806 [B6A8C7-1] ENST00000612678; ENSP00000482624; ENSG00000275123 [B6A8C7-1] ENST00000614463; ENSP00000480049; ENSG00000276355 [B6A8C7-1] ENST00000615726; ENSP00000479185; ENSG00000275384 [B6A8C7-1] ENST00000619320; ENSP00000479062; ENSG00000276604 [B6A8C7-1] ENST00000620140; ENSP00000477830; ENSG00000276355 [B6A8C7-2] ENST00000620398; ENSP00000479374; ENSG00000273875 [B6A8C7-1] ENST00000620707; ENSP00000480377; ENSG00000277178 [B6A8C7-1] ENST00000622245; ENSP00000478822; ENSG00000274889 [B6A8C7-1]
GeneIDⁱ	441864
KEGGⁱ	hsa:441864
UCSC genome browser More...UCSCⁱ	uc010yei.1 human [B6A8C7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
B6A8C7	T-cell-interacting,-activating receptor on myeloid cells protein 1		HUMAN		279	UniRef90_B6A8C7
T cell-interacting, activating receptor on myeloid cells 1		PANTR		274
Uncharacterized protein		PANPA		273
T cell-interacting, activating receptor on myeloid cells 1		GORGO		271
Isoform 2 of T-cell-interacting, activating receptor on myeloid cells protein 1		HUMAN		279
+5

Protein	Similar proteins		Species	Score	Length	Source
B6A8C7	T-cell-interacting,-activating receptor on myeloid cells protein 1		HUMAN		279	UniRef50_B6A8C7
T cell-interacting, activating receptor on myeloid cells 1		PANTR		274
Uncharacterized protein		PANPA		273
T cell-interacting, activating receptor on myeloid cells 1		GORGO		271
T cell-interacting, activating receptor on myeloid cells 1		BOVIN		271
+51

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ479398 mRNA Translation: ABF19808.1 AK301730 mRNA Translation: BAG63196.1 AC012314 Genomic DNA No translation available.
CCDSⁱ	CCDS46173.1 [B6A8C7-1] CCDS82395.1 [B6A8C7-2]
RefSeqⁱ	NP_001129158.2, NM_001135686.2 NP_001317579.1, NM_001330650.1
UniGeneⁱ	Hs.694674

3D structure databases

ProteinModelPortalⁱ	B6A8C7
SMRⁱ	B6A8C7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

PTM databases

iPTMnetⁱ	B6A8C7
PhosphoSitePlusⁱ	B6A8C7

Proteomic databases

PaxDbⁱ	B6A8C7
PRIDEⁱ	B6A8C7
ProteomicsDBⁱ	6241 6242 [B6A8C7-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Organism-specific databases

CTDⁱ	441864
EuPathDBⁱ	HostDB:ENSG00000248385.7
GeneCardsⁱ	TARM1
HGNCⁱ	HGNC:37250 TARM1
HPAⁱ	HPA051022 HPA054401
neXtProtⁱ	NX_B6A8C7
PharmGKBⁱ	PA165394443
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J9W1 Eukaryota ENOG411166F LUCA
HOGENOMⁱ	HOG000234395
HOVERGENⁱ	HBG105594
InParanoidⁱ	B6A8C7
OrthoDBⁱ	EOG091G0IK8
PhylomeDBⁱ	B6A8C7
TreeFamⁱ	TF336644

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

GenomeRNAiⁱ	441864
Protein Ontology More...PROⁱ	PR:B6A8C7

Gene expression databases

Bgeeⁱ	ENSG00000248385 Expressed in 9 organ(s), highest expression level in blood
ExpressionAtlasⁱ	B6A8C7 baseline and differential

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub
Pfamⁱ	View protein in Pfam PF13895 Ig_2, 2 hits
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TARM1_HUMAN
Accessionⁱ	B6A8C7Primary (citable) accession number: B6A8C7 Secondary accession number(s): B4DWY4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 18, 2010
	Last sequence update:	November 25, 2008
	Last modified:	September 12, 2018
	This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - B6A8C7 (TARM1_HUMAN)

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T-cell-interacting, activating receptor on myeloid cells protein 1

TARM1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ