UniProtKB - B6A8C7 (TARM1_HUMAN)
T-cell-interacting, activating receptor on myeloid cells protein 1
TARM1
Functioni
May act as receptor (By similarity).
Negatively regulates TCR-mediated CD4+ T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface (PubMed:26311901).
Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils (By similarity).
By similarity1 PublicationGO - Molecular functioni
- immunoglobulin receptor binding Source: UniProtKB
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- negative regulation of CD4-positive, alpha-beta T cell activation Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | B6A8C7 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell-interacting, activating receptor on myeloid cells protein 1Alternative name(s): OSCAR-like transcript-2 protein Short name: OLT-2 |
Gene namesi | Name:TARM1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:37250, TARM1 |
neXtProti | NX_B6A8C7 |
VEuPathDBi | HostDB:ENSG00000248385 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- specific granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 17 – 236 | ExtracellularSequence analysisAdd BLAST | 220 | |
Transmembranei | 237 – 257 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 258 – 271 | CytoplasmicSequence analysisAdd BLAST | 14 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA165394443 |
Miscellaneous databases
Pharosi | B6A8C7, Tdark |
Genetic variation databases
BioMutai | TARM1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000394231 | 17 – 271 | T-cell-interacting, activating receptor on myeloid cells protein 1Add BLAST | 255 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 44 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 49 ↔ 97 | PROSITE-ProRule annotation | ||
Disulfide bondi | 146 ↔ 196 | PROSITE-ProRule annotation |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | B6A8C7 |
PaxDbi | B6A8C7 |
PeptideAtlasi | B6A8C7 |
PRIDEi | B6A8C7 |
PTM databases
GlyGeni | B6A8C7, 1 site |
iPTMneti | B6A8C7 |
PhosphoSitePlusi | B6A8C7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000248385, Expressed in bone marrow and 19 other tissues |
ExpressionAtlasi | B6A8C7, baseline and differential |
Organism-specific databases
HPAi | ENSG00000248385, Tissue enriched (bone) |
Interactioni
Subunit structurei
Interacts with Fc receptor gamma chain FCER1G.
1 PublicationGO - Molecular functioni
- immunoglobulin receptor binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9606.ENSP00000439454 |
Miscellaneous databases
RNActi | B6A8C7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 113 | Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 126 – 212 | Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST | 87 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYEX, Eukaryota |
HOGENOMi | CLU_021100_1_0_1 |
InParanoidi | B6A8C7 |
OrthoDBi | 1327293at2759 |
PhylomeDBi | B6A8C7 |
TreeFami | TF336644 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIPKLLSLLC FRLCVGQGDT RGDGSLPKPS LSAWPSSVVP ANSNVTLRCW
60 70 80 90 100
TPARGVSFVL RKGGIILESP KPLDSTEGAA EFHLNNLKVR NAGEYTCEYY
110 120 130 140 150
RKASPHILSQ RSDVLLLLVT GHLSKPFLRT YQRGTVTAGG RVTLQCQKRD
160 170 180 190 200
QLFVPIMFAL LKAGTPSPIQ LQSPAGKEID FSLVDVTAGD AGNYSCMYYQ
210 220 230 240 250
TKSPFWASEP SDQLEILVTV PPGTTSSNYS LGNFVRLGLA AVIVVIMGAF
260 270
LVEAWYSRNV SPGESEAFKP E
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X1Q6 | A0A087X1Q6_HUMAN | T-cell-interacting,-activating rece... | TARM1 | 279 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063151 | 37 | S → P. Corresponds to variant dbSNP:rs17305269Ensembl. | 1 | |
Natural variantiVAR_063152 | 111 | R → H. Corresponds to variant dbSNP:rs80087697Ensembl. | 1 | |
Natural variantiVAR_063153 | 258 | R → W. Corresponds to variant dbSNP:rs77768804Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039225 | 1 – 12 | MIPKL…LLCFR → MKERKKKERKERKRKKERNG in isoform 2. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ479398 mRNA Translation: ABF19808.1 AK301730 mRNA Translation: BAG63196.1 AC012314 Genomic DNA No translation available. |
CCDSi | CCDS46173.1 [B6A8C7-1] CCDS82395.1 [B6A8C7-2] |
RefSeqi | NP_001129158.2, NM_001135686.2 NP_001317579.1, NM_001330650.1 |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ479398 mRNA Translation: ABF19808.1 AK301730 mRNA Translation: BAG63196.1 AC012314 Genomic DNA No translation available. |
CCDSi | CCDS46173.1 [B6A8C7-1] CCDS82395.1 [B6A8C7-2] |
RefSeqi | NP_001129158.2, NM_001135686.2 NP_001317579.1, NM_001330650.1 |
3D structure databases
AlphaFoldDBi | B6A8C7 |
SMRi | B6A8C7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000439454 |
PTM databases
GlyGeni | B6A8C7, 1 site |
iPTMneti | B6A8C7 |
PhosphoSitePlusi | B6A8C7 |
Genetic variation databases
BioMutai | TARM1 |
Proteomic databases
MassIVEi | B6A8C7 |
PaxDbi | B6A8C7 |
PeptideAtlasi | B6A8C7 |
PRIDEi | B6A8C7 |
Protocols and materials databases
Antibodypediai | 65161, 80 antibodies from 15 providers |
DNASUi | 441864 |
Genome annotation databases
Organism-specific databases
CTDi | 441864 |
GeneCardsi | TARM1 |
HGNCi | HGNC:37250, TARM1 |
HPAi | ENSG00000248385, Tissue enriched (bone) |
neXtProti | NX_B6A8C7 |
PharmGKBi | PA165394443 |
VEuPathDBi | HostDB:ENSG00000248385 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYEX, Eukaryota |
HOGENOMi | CLU_021100_1_0_1 |
InParanoidi | B6A8C7 |
OrthoDBi | 1327293at2759 |
PhylomeDBi | B6A8C7 |
TreeFami | TF336644 |
Enzyme and pathway databases
PathwayCommonsi | B6A8C7 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 441864, 15 hits in 1062 CRISPR screens |
ChiTaRSi | TARM1, human |
GenomeRNAii | 441864 |
Pharosi | B6A8C7, Tdark |
PROi | PR:B6A8C7 |
RNActi | B6A8C7, protein |
Gene expression databases
Bgeei | ENSG00000248385, Expressed in bone marrow and 19 other tissues |
ExpressionAtlasi | B6A8C7, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TARM1_HUMAN | |
Accessioni | B6A8C7Primary (citable) accession number: B6A8C7 Secondary accession number(s): B4DWY4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 18, 2010 |
Last sequence update: | November 25, 2008 | |
Last modified: | May 25, 2022 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports