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Protein

T-cell-interacting, activating receptor on myeloid cells protein 1

Gene

TARM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as receptor (By similarity). Negatively regulates TCR-mediated CD4+ T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface (PubMed:26311901). Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils (By similarity).By similarity1 Publication

GO - Molecular functioni

  • immunoglobulin receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell-interacting, activating receptor on myeloid cells protein 1
Alternative name(s):
OSCAR-like transcript-2 protein
Short name:
OLT-2
Gene namesi
Name:TARM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000248385.7
HGNCiHGNC:37250 TARM1
neXtProtiNX_B6A8C7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 236ExtracellularSequence analysisAdd BLAST220
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 271CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394443

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000039423117 – 271T-cell-interacting, activating receptor on myeloid cells protein 1Add BLAST255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi49 ↔ 97PROSITE-ProRule annotation
Disulfide bondi146 ↔ 196PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiB6A8C7
PRIDEiB6A8C7
ProteomicsDBi6241
6242 [B6A8C7-2]

PTM databases

iPTMnetiB6A8C7
PhosphoSitePlusiB6A8C7

Expressioni

Tissue specificityi

Expressed in fetal and adult liver, lung, testis, thymus and spleen. Expressed in blood neutrophils.1 Publication

Gene expression databases

BgeeiENSG00000248385 Expressed in 9 organ(s), highest expression level in blood
ExpressionAtlasiB6A8C7 baseline and differential

Organism-specific databases

HPAiHPA051022
HPA054401

Interactioni

Subunit structurei

Interacts with Fc receptor gamma chain FCER1G.1 Publication

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB6A8C7
SMRiB6A8C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 113Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST87
Domaini126 – 212Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST87

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9W1 Eukaryota
ENOG411166F LUCA
HOGENOMiHOG000234395
HOVERGENiHBG105594
InParanoidiB6A8C7
OrthoDBiEOG091G0IK8
PhylomeDBiB6A8C7
TreeFamiTF336644

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: B6A8C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPKLLSLLC FRLCVGQGDT RGDGSLPKPS LSAWPSSVVP ANSNVTLRCW
60 70 80 90 100
TPARGVSFVL RKGGIILESP KPLDSTEGAA EFHLNNLKVR NAGEYTCEYY
110 120 130 140 150
RKASPHILSQ RSDVLLLLVT GHLSKPFLRT YQRGTVTAGG RVTLQCQKRD
160 170 180 190 200
QLFVPIMFAL LKAGTPSPIQ LQSPAGKEID FSLVDVTAGD AGNYSCMYYQ
210 220 230 240 250
TKSPFWASEP SDQLEILVTV PPGTTSSNYS LGNFVRLGLA AVIVVIMGAF
260 270
LVEAWYSRNV SPGESEAFKP E
Note: No experimental confirmation available.
Length:271
Mass (Da):29,474
Last modified:November 25, 2008 - v1
Checksum:iB1E2B17A1C657060
GO
Isoform 2 (identifier: B6A8C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MIPKLLSLLCFR → MKERKKKERKERKRKKERNG

Note: No experimental confirmation available.
Show »
Length:279
Mass (Da):30,683
Checksum:i42E4CECB90930F2B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1Q6A0A087X1Q6_HUMAN
T-cell-interacting,-activating rece...
TARM1
279Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06315137S → P. Corresponds to variant dbSNP:rs17305269Ensembl.1
Natural variantiVAR_063152111R → H. Corresponds to variant dbSNP:rs80087697Ensembl.1
Natural variantiVAR_063153258R → W. Corresponds to variant dbSNP:rs77768804Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0392251 – 12MIPKL…LLCFR → MKERKKKERKERKRKKERNG in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ479398 mRNA Translation: ABF19808.1
AK301730 mRNA Translation: BAG63196.1
AC012314 Genomic DNA No translation available.
CCDSiCCDS46173.1 [B6A8C7-1]
CCDS82395.1 [B6A8C7-2]
RefSeqiNP_001129158.2, NM_001135686.2
NP_001317579.1, NM_001330650.1
UniGeneiHs.694674

Genome annotation databases

EnsembliENST00000432826; ENSP00000439454; ENSG00000248385
ENST00000611088; ENSP00000479824; ENSG00000276145 [B6A8C7-1]
ENST00000611419; ENSP00000478234; ENSG00000275806 [B6A8C7-1]
ENST00000612678; ENSP00000482624; ENSG00000275123 [B6A8C7-1]
ENST00000614463; ENSP00000480049; ENSG00000276355 [B6A8C7-1]
ENST00000615726; ENSP00000479185; ENSG00000275384 [B6A8C7-1]
ENST00000619320; ENSP00000479062; ENSG00000276604 [B6A8C7-1]
ENST00000620140; ENSP00000477830; ENSG00000276355 [B6A8C7-2]
ENST00000620398; ENSP00000479374; ENSG00000273875 [B6A8C7-1]
ENST00000620707; ENSP00000480377; ENSG00000277178 [B6A8C7-1]
ENST00000622245; ENSP00000478822; ENSG00000274889 [B6A8C7-1]
GeneIDi441864
KEGGihsa:441864
UCSCiuc010yei.1 human [B6A8C7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ479398 mRNA Translation: ABF19808.1
AK301730 mRNA Translation: BAG63196.1
AC012314 Genomic DNA No translation available.
CCDSiCCDS46173.1 [B6A8C7-1]
CCDS82395.1 [B6A8C7-2]
RefSeqiNP_001129158.2, NM_001135686.2
NP_001317579.1, NM_001330650.1
UniGeneiHs.694674

3D structure databases

ProteinModelPortaliB6A8C7
SMRiB6A8C7
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiB6A8C7
PhosphoSitePlusiB6A8C7

Proteomic databases

PaxDbiB6A8C7
PRIDEiB6A8C7
ProteomicsDBi6241
6242 [B6A8C7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432826; ENSP00000439454; ENSG00000248385
ENST00000611088; ENSP00000479824; ENSG00000276145 [B6A8C7-1]
ENST00000611419; ENSP00000478234; ENSG00000275806 [B6A8C7-1]
ENST00000612678; ENSP00000482624; ENSG00000275123 [B6A8C7-1]
ENST00000614463; ENSP00000480049; ENSG00000276355 [B6A8C7-1]
ENST00000615726; ENSP00000479185; ENSG00000275384 [B6A8C7-1]
ENST00000619320; ENSP00000479062; ENSG00000276604 [B6A8C7-1]
ENST00000620140; ENSP00000477830; ENSG00000276355 [B6A8C7-2]
ENST00000620398; ENSP00000479374; ENSG00000273875 [B6A8C7-1]
ENST00000620707; ENSP00000480377; ENSG00000277178 [B6A8C7-1]
ENST00000622245; ENSP00000478822; ENSG00000274889 [B6A8C7-1]
GeneIDi441864
KEGGihsa:441864
UCSCiuc010yei.1 human [B6A8C7-1]

Organism-specific databases

CTDi441864
EuPathDBiHostDB:ENSG00000248385.7
GeneCardsiTARM1
HGNCiHGNC:37250 TARM1
HPAiHPA051022
HPA054401
neXtProtiNX_B6A8C7
PharmGKBiPA165394443
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9W1 Eukaryota
ENOG411166F LUCA
HOGENOMiHOG000234395
HOVERGENiHBG105594
InParanoidiB6A8C7
OrthoDBiEOG091G0IK8
PhylomeDBiB6A8C7
TreeFamiTF336644

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

GenomeRNAii441864
PROiPR:B6A8C7

Gene expression databases

BgeeiENSG00000248385 Expressed in 9 organ(s), highest expression level in blood
ExpressionAtlasiB6A8C7 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTARM1_HUMAN
AccessioniPrimary (citable) accession number: B6A8C7
Secondary accession number(s): B4DWY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: November 25, 2008
Last modified: September 12, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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