Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 57 (02 Dec 2020)
Sequence version 1 (25 Nov 2008)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Cytotoxin-associated protein A

Gene

cagA

Organism
Helicobacter pylori (strain G27)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
HPYL563041:G1GTQ-541-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cytotoxin-associated protein AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cagAImported
Ordered Locus Names:HPG27_507Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain G27)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri563041 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001735 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
B5Z6S0, 2 interactors

Molecular INTeraction database

More...
MINTi
B5Z6S0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B5Z6S0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini936 – 974CagAInterPro annotationAdd BLAST39
Domaini975 – 1008CagAInterPro annotationAdd BLAST34
Domaini1009 – 1041CagAInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni627 – 648DisorderedSequence analysisAdd BLAST22
Regioni1206 – 1230DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili400 – 420Sequence analysisAdd BLAST21
Coiled coili673 – 700Sequence analysisAdd BLAST28
Coiled coili1031 – 1051Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008105_0_0_7

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNYKFNQ

Database of Orthologous Groups

More...
OrthoDBi
8247at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005169, CagA
IPR004355, IVSec_CagA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03507, CagA, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01553, TYPE4SSCAGA

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B5Z6S0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNETINQQP QTEAAFNPQQ FINNLQVAFL KVDNAVASYD PDQKPIVDKN
60 70 80 90 100
DRDNRQAFNG ISQLREEYSN KAIKNPAKKN QYFSDFIDKS NNLINKDALI
110 120 130 140 150
DVESSTKSFQ KFGDQRYQIF TSWVSHQNDP SKINTRSIRN FMENIIQPPI
160 170 180 190 200
PDDKEKAEFL KSAKQSFAGI IIGNQIRTDQ KFMGVFDESL KERQEAEKNG
210 220 230 240 250
GPTGGDWLDI FLSFIFDKKQ SSDVKEAINQ EPVPHVQPDI ATTTTDIQGL
260 270 280 290 300
PPEARDLLDE RGNFSKFTLG DMEMLDVEGV ADIDPNYKFN QLLIHNNALS
310 320 330 340 350
SVLMGSHNGI EPEKVSLLYG GNGGPKAKHD WNATVGYKDQ QGNNVATIIN
360 370 380 390 400
VHMKNGSGLV IAGGEKGINN PSFYLYKEDQ LTGSQRALSQ EEIRNKVDFM
410 420 430 440 450
EFLAQNNAKL DNLSEKEEEK FRNEIKDFQK DSKAYLDALG NDRIAFVSKK
460 470 480 490 500
DTKHSALITE FGNGDLSYTL KDYGKKADKA LDREKNVTLQ GNLKHDGVMF
510 520 530 540 550
VDYSNFKYTN ASKNPNKGVG VTNGVSHLEA GFSKVAVFNL PDLNNLAITS
560 570 580 590 600
LVRRDLEDKL IAKGLSPQET NKLVKDFLSS NKELVGKALN FNKAVAEAKN
610 620 630 640 650
TGNYDEVKQA QKDLEKSLKK RERLEKEVAK KLESKSGNKN KMEAKSQANS
660 670 680 690 700
QKDEIFALIN KEANREARAI TYAQNLKGIK RELSDKLENV NKNLKDFSKS
710 720 730 740 750
FDEFKNGKNK DFSKSEETLK ALKGSVKDLG INPEWISKVE NLNAALNEFK
760 770 780 790 800
NGKNKDFSKV TQAKSDLENS VKDVIINQKV TDKVDNLNQA VSVAKATGDF
810 820 830 840 850
SRVEQALADL KNFSKEQLAQ QAQKNEDFNT GKNSALYQSV KNGVNGTLVG
860 870 880 890 900
NGLSKAEATT LSKNFSDIKK ELNAKLGNFN NNNNNGLKNS TEPIYAKVNK
910 920 930 940 950
KKAGQAASPE EPIYAQVAKK VNAKIDRLNQ IASGLGVVGQ AVGFPLKRHD
960 970 980 990 1000
KVGDLSKVGQ SVSPEPIYAT IDDLGGPFPL KRHDKVGDLS KVGLSVSPEP
1010 1020 1030 1040 1050
IYATIDDLGG PFPLKRHDKV GDLSKVGLSR EQQLKQKIDN LSQAVSEAKA
1060 1070 1080 1090 1100
GFFGNLEQTI DNLKDSAKNN PVSLWAEGAK KVPASLSAKL DNYATNSHTR
1110 1120 1130 1140 1150
INSNIQSGAI NEKATGMLTQ KNPEWLKLVN DKIVAHNVGS VPLLEYDKIG
1160 1170 1180 1190 1200
FNQKSMKDYS DSFKFSTELN NAVKDVKSGF TQFLANAFST GYYRLAGENA
1210 1220 1230
EHGIKNVNTK GGSKNLKGLR NTKNAKTTPC
Length:1,230
Mass (Da):136,175
Last modified:November 25, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i524AA88826DEE73C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP001173 Genomic DNA Translation: ACI27269.1

NCBI Reference Sequences

More...
RefSeqi
WP_000180783.1, NC_011333.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACI27269; ACI27269; HPG27_507

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hpg:HPG27_507

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001173 Genomic DNA Translation: ACI27269.1
RefSeqiWP_000180783.1, NC_011333.1

3D structure databases

SMRiB5Z6S0
ModBaseiSearch...

Protein-protein interaction databases

IntActiB5Z6S0, 2 interactors
MINTiB5Z6S0

Genome annotation databases

EnsemblBacteriaiACI27269; ACI27269; HPG27_507
KEGGihpg:HPG27_507

Phylogenomic databases

HOGENOMiCLU_008105_0_0_7
OMAiPNYKFNQ
OrthoDBi8247at2

Enzyme and pathway databases

BioCyciHPYL563041:G1GTQ-541-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR005169, CagA
IPR004355, IVSec_CagA
PfamiView protein in Pfam
PF03507, CagA, 3 hits
PRINTSiPR01553, TYPE4SSCAGA

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB5Z6S0_HELPG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B5Z6S0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: December 2, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again