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Protein

Anaerobic glycerol-3-phosphate dehydrogenase subunit B

Gene

glpB

Organism
Escherichia coli O157:H7 (strain EC4115 / EHEC)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.UniRule annotation

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.UniRule annotation

Cofactori

FMNUniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Anaerobic glycerol-3-phosphate dehydrogenase subunit B (glpB)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN

Enzyme and pathway databases

UniPathwayi
UPA00618;UER00673

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic glycerol-3-phosphate dehydrogenase subunit BUniRule annotation (EC:1.1.5.3UniRule annotation)
Short name:
Anaerobic G-3-P dehydrogenase subunit BUniRule annotation
Short name:
Anaerobic G3Pdhase BUniRule annotation
Gene namesi
Name:glpBUniRule annotation
Ordered Locus Names:ECH74115_3379
OrganismiEscherichia coli O157:H7 (strain EC4115 / EHEC)
Taxonomic identifieri444450 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001333561 – 419Anaerobic glycerol-3-phosphate dehydrogenase subunit BAdd BLAST419

Interactioni

Subunit structurei

Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB5YX30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anaerobic G-3-P dehydrogenase subunit B family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000278489
KOiK00112
OMAiVAINAQC

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00753 Glycerol3P_GlpB, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR009158 G3P_DH_GlpB_su
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PIRSFiPIRSF000141 Anaerobic_G3P_dh, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR03378 glycerol3P_GlpB, 1 hit

Sequencei

Sequence statusi: Complete.

B5YX30-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFDTIIMGG GLAGLLCGLQ LQKHGLRCAI VTRGQSALHF SSGSLDLLSH
60 70 80 90 100
LPDGQAVTDI HSGLESLRQQ APAHPYSLLG PQRVLDLACQ AQALIAESGA
110 120 130 140 150
QLQGSVELPH QRITPLGTLR STWLSSPEVP VWPLPAKKIC VVGISGLMDF
160 170 180 190 200
QAHLAAASLR ELDLAVETAE IELPELDVLR NNATEFRAVN IARFLDNEEN
210 220 230 240 250
WPLLLDALIP VANTCEMILM PACFGLADDK LWRWLNEKLP CSLMLLPTLP
260 270 280 290 300
PSVLGIRLQN QLQRQFVRQG GVWMPGDEVK KVTCKNGVVN EIWTRNHADI
310 320 330 340 350
PLRPRFAVLA SGSFFSGGLV AERNGIREPI LGLDVLQTAT RGEWYKGDFF
360 370 380 390 400
APQPWQQFGV TTDQTLRPSQ AGQTIENLFT IGSVLGGFDP IAQGCGGGVC
410
AVSALHAAQQ IAQRAGGQQ
Length:419
Mass (Da):45,400
Last modified:November 25, 2008 - v1
Checksum:i19AC63B458F1BA5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001164 Genomic DNA Translation: ACI36262.1
RefSeqiWP_001209872.1, NC_011353.1

Genome annotation databases

EnsemblBacteriaiACI36262; ACI36262; ECH74115_3379
KEGGiecf:ECH74115_3379

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001164 Genomic DNA Translation: ACI36262.1
RefSeqiWP_001209872.1, NC_011353.1

3D structure databases

ProteinModelPortaliB5YX30
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACI36262; ACI36262; ECH74115_3379
KEGGiecf:ECH74115_3379

Phylogenomic databases

HOGENOMiHOG000278489
KOiK00112
OMAiVAINAQC

Enzyme and pathway databases

UniPathwayi
UPA00618;UER00673

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00753 Glycerol3P_GlpB, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR009158 G3P_DH_GlpB_su
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PIRSFiPIRSF000141 Anaerobic_G3P_dh, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR03378 glycerol3P_GlpB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLPB_ECO5E
AccessioniPrimary (citable) accession number: B5YX30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 25, 2008
Last modified: October 10, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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