UniProtKB - B5YPZ7 (BTUD_ECO5E)
Protein
Vitamin B12 import ATP-binding protein BtuD
Gene
btuD
Organism
Escherichia coli O157:H7 (strain EC4115 / EHEC)
Status
Functioni
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.UniRule annotation
Catalytic activityi
- EC:7.6.2.8UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 33 – 40 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled vitamin B12 transmembrane transporter activity Source: UniProtKB-UniRule
- ATP binding Source: UniProtKB-KW
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Vitamin B12 import ATP-binding protein BtuDUniRule annotation (EC:7.6.2.8UniRule annotation)Alternative name(s): Vitamin B12-transporting ATPaseUniRule annotation |
Gene namesi | Name:btuDUniRule annotation Ordered Locus Names:ECH74115_2427 |
Organismi | Escherichia coli O157:H7 (strain EC4115 / EHEC) |
Taxonomic identifieri | 444450 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Subcellular locationi
- Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation
GO - Cellular componenti
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000134659 | 1 – 249 | Vitamin B12 import ATP-binding protein BtuDAdd BLAST | 249 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 233 | ABC transporterUniRule annotationAdd BLAST | 233 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family. [View classification]UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_000604_1_11_6 |
OMAi | HHADRVW |
Family and domain databases
HAMAPi | MF_01005, BtuD, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR023693, ABC_transptr_BtuD IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B5YPZ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSIVMQLQDV AESTRLGPLS GEVRAGEILH LVGPNGAGKS TLLARMAGMT
60 70 80 90 100
SGKGSIQFAG QPLEAWSATK LALHRAYLSQ QQTPPFAMPV WHYLTLHQHD
110 120 130 140 150
KTRTELLNDV AGALALDDKL GRSTNQLSGG EWQRVRLAAV VLQITPQANP
160 170 180 190 200
AGQLLLLDEP MNSLDVAQQS ALDKILSALC QQGLAIVMSS HDLNHTLRHA
210 220 230 240
HRAWLLKGGK MLASGRREDV LTPPNLAQAY GMNFRRLDIE GHRMLISTI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001164 Genomic DNA Translation: ACI35653.1 |
RefSeqi | WP_000029463.1, NC_011353.1 |
Genome annotation databases
EnsemblBacteriai | ACI35653; ACI35653; ECH74115_2427 |
KEGGi | ecf:ECH74115_2427 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001164 Genomic DNA Translation: ACI35653.1 |
RefSeqi | WP_000029463.1, NC_011353.1 |
3D structure databases
SMRi | B5YPZ7 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | ACI35653; ACI35653; ECH74115_2427 |
KEGGi | ecf:ECH74115_2427 |
Phylogenomic databases
HOGENOMi | CLU_000604_1_11_6 |
OMAi | HHADRVW |
Family and domain databases
HAMAPi | MF_01005, BtuD, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR023693, ABC_transptr_BtuD IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BTUD_ECO5E | |
Accessioni | B5YPZ7Primary (citable) accession number: B5YPZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 14, 2009 |
Last sequence update: | November 25, 2008 | |
Last modified: | December 2, 2020 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |