UniProtKB - B5YKK8 (B5YKK8_THEYD)
Protein
D-3-phosphoglycerate dehydrogenase
Gene
serA
Organism
Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Status
Functioni
Catalytic activityi
- EC:1.1.1.95UniRule annotation
: L-serine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.UniRule annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- D-3-phosphoglycerate dehydrogenase (serA)
- no protein annotated in this organism
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- NAD binding Source: UniProtKB-UniRule
- phosphoglycerate dehydrogenase activity Source: GO_Central
GO - Biological processi
- cellular amino acid metabolic process Source: GO_Central
- L-serine biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | OxidoreductaseUniRule annotationImported |
Biological process | Amino-acid biosynthesis, Serine biosynthesisUniRule annotation |
Ligand | NADUniRule annotation |
Enzyme and pathway databases
BioCyci | TYEL289376:G1GCQ-936-MONOMER |
UniPathwayi | UPA00135;UER00196 |
Names & Taxonomyi
Protein namesi | Recommended name: D-3-phosphoglycerate dehydrogenaseUniRule annotation (EC:1.1.1.95UniRule annotation) |
Gene namesi | Name:serAImported Ordered Locus Names:THEYE_A0937Imported |
Organismi | Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)Imported |
Taxonomic identifieri | 289376 [NCBI] |
Taxonomic lineagei | Bacteria › Nitrospirae › Nitrospirales › Nitrospiraceae › Thermodesulfovibrio › |
Proteomesi |
|
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 454 – 526 | ACTInterPro annotationAdd BLAST | 73 |
Sequence similaritiesi
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4108JQ1 Bacteria COG0111 LUCA |
HOGENOMi | HOG000136693 |
InParanoidi | B5YKK8 |
KOi | K00058 |
OMAi | NIAGMQV |
OrthoDBi | 1638924at2 |
Family and domain databases
Gene3Di | 3.30.1330.90, 1 hit |
InterProi | View protein in InterPro IPR002912 ACT_dom IPR029009 ASB_dom_sf IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf IPR006236 PGDH |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit PF01842 ACT, 1 hit |
SUPFAMi | SSF143548 SSF143548, 1 hit SSF51735 SSF51735, 1 hit |
TIGRFAMsi | TIGR01327 PGDH, 1 hit |
PROSITEi | View protein in PROSITE PS51671 ACT, 1 hit PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00670 D_2_HYDROXYACID_DH_2, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
i Sequence
Sequence statusi: Complete.
B5YKK8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVLVSDSIS SKGVEILKKA GFEVDVKTGL KPEELKSIIG EYDALIIRSA
60 70 80 90 100
TKVTAEIIDA ADKLKVIGRA GTGVDNVDKI AATKKGIVVM NTPGGNTITT
110 120 130 140 150
AEHAIAMLFS LARRIPQATA SMKSGKWEKK KFMGVELYNK TIGIIGLGRI
160 170 180 190 200
GSEVAKRTQC MGMNVLAYDP FLSDERAEEL GITKTDLDKI FAEADFITIH
210 220 230 240 250
TPLTSETKYL INKNTIEKMK KGVYIINCAR GGIVNEKDLY DAIQSGKVAG
260 270 280 290 300
AALDVFEKEP PEEGYALITD ERVICTPHLG ASTLEAQENV AVAIAEQVVD
310 320 330 340 350
YLINGTIRNA VNFPSIPFDQ VPLIRPYLVL LERMGSFVSQ IFTKSIKQVQ
360 370 380 390 400
IEYLGEISNL NTQALTAAAL KGILDPILGE PVNYVNASFI AKERGIEVRE
410 420 430 440 450
IKGKEAGDYQ SLVRITLISK DDRAVIAGTL LSRKDPRIVQ INDISMEIIP
460 470 480 490 500
EGNMIFLRNH DRPGVIGNIG TLLGQNNINI GHMHFGRKEA GGIAFSVISV
510 520
DATLTDDIIE KIKQLPNVLE VRPVYISVH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001147 Genomic DNA Translation: ACI21985.1 |
RefSeqi | WP_012546680.1, NC_011296.1 YP_002248773.1, NC_011296.1 |
Genome annotation databases
EnsemblBacteriai | ACI21985; ACI21985; THEYE_A0937 |
GeneIDi | 6941939 |
KEGGi | tye:THEYE_A0937 |
PATRICi | fig|289376.4.peg.923 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001147 Genomic DNA Translation: ACI21985.1 |
RefSeqi | WP_012546680.1, NC_011296.1 YP_002248773.1, NC_011296.1 |
3D structure databases
ProteinModelPortali | B5YKK8 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 289376.THEYE_A0937 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
EnsemblBacteriai | ACI21985; ACI21985; THEYE_A0937 |
GeneIDi | 6941939 |
KEGGi | tye:THEYE_A0937 |
PATRICi | fig|289376.4.peg.923 |
Phylogenomic databases
eggNOGi | ENOG4108JQ1 Bacteria COG0111 LUCA |
HOGENOMi | HOG000136693 |
InParanoidi | B5YKK8 |
KOi | K00058 |
OMAi | NIAGMQV |
OrthoDBi | 1638924at2 |
Enzyme and pathway databases
UniPathwayi | UPA00135;UER00196 |
BioCyci | TYEL289376:G1GCQ-936-MONOMER |
Family and domain databases
Gene3Di | 3.30.1330.90, 1 hit |
InterProi | View protein in InterPro IPR002912 ACT_dom IPR029009 ASB_dom_sf IPR006139 D-isomer_2_OHA_DH_cat_dom IPR029753 D-isomer_DH_CS IPR029752 D-isomer_DH_CS1 IPR006140 D-isomer_DH_NAD-bd IPR036291 NAD(P)-bd_dom_sf IPR006236 PGDH |
Pfami | View protein in Pfam PF00389 2-Hacid_dh, 1 hit PF02826 2-Hacid_dh_C, 1 hit PF01842 ACT, 1 hit |
SUPFAMi | SSF143548 SSF143548, 1 hit SSF51735 SSF51735, 1 hit |
TIGRFAMsi | TIGR01327 PGDH, 1 hit |
PROSITEi | View protein in PROSITE PS51671 ACT, 1 hit PS00065 D_2_HYDROXYACID_DH_1, 1 hit PS00670 D_2_HYDROXYACID_DH_2, 1 hit PS00671 D_2_HYDROXYACID_DH_3, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | B5YKK8_THEYD | |
Accessioni | B5YKK8Primary (citable) accession number: B5YKK8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 25, 2008 |
Last sequence update: | November 25, 2008 | |
Last modified: | January 16, 2019 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |