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Entry version 117 (29 Sep 2021)
Sequence version 1 (25 Nov 2008)
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Protein
Submitted name:

IP21864p

Gene

Lrp4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImportedARBA annotation
Biological processEndocytosisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
IP21864pImported
Submitted name:
LDL receptor related protein 4, isoform CImported
Submitted name:
LDL receptor related protein 4, isoform DImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrp4Imported
Synonyms:CG8909-RBImported, CT25574Imported, Dm CG8909Imported, Dmel\CG8909Imported, LRP4Imported, lrp4Imported
ORF Names:CG8909Imported, Dmel_CG8909Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0030706, Lrp4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0030706

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1889 – 1914HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501508734623 – 2008Sequence analysisAdd BLAST1986

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi246 ↔ 261PROSITE-ProRule annotation
Disulfide bondi267 ↔ 279PROSITE-ProRule annotation
Disulfide bondi274 ↔ 292PROSITE-ProRule annotation
Disulfide bondi286 ↔ 301PROSITE-ProRule annotation
Disulfide bondi306 ↔ 318PROSITE-ProRule annotation
Disulfide bondi313 ↔ 331PROSITE-ProRule annotation
Disulfide bondi325 ↔ 340PROSITE-ProRule annotation
Disulfide bondi375 ↔ 390PROSITE-ProRule annotation
Disulfide bondi397 ↔ 409PROSITE-ProRule annotation
Disulfide bondi404 ↔ 422PROSITE-ProRule annotation
Disulfide bondi416 ↔ 431PROSITE-ProRule annotation
Disulfide bondi442 ↔ 454PROSITE-ProRule annotation
Disulfide bondi449 ↔ 467PROSITE-ProRule annotation
Disulfide bondi461 ↔ 476PROSITE-ProRule annotation
Disulfide bondi506 ↔ 521PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B5X533

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0030706, Expressed in head and 23 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B5X533, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
B5X533, 85 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B5X533

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini589 – 604EGF-likeInterPro annotationAdd BLAST16
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati651 – 693LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati694 – 736LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati737 – 780LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati781 – 823LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati965 – 1007LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1008 – 1050LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1051 – 1094LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1095 – 1136LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati1269 – 1311LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1312 – 1354LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1355 – 1398LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1399 – 1440LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati1576 – 1619LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1620 – 1662LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1663 – 1706LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni89 – 140DisorderedSequence analysisAdd BLAST52
Regioni190 – 212DisorderedSequence analysisAdd BLAST23
Regioni1855 – 1881DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi115 – 139Polar residuesSequence analysisAdd BLAST25
Compositional biasi191 – 207Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

EGF-like domainARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158366

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000085_4_1_1

Database of Orthologous Groups

More...
OrthoDBi
121310at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B5X533

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 4 hits
4.10.400.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645, EGF_CA, 1 hit
PF00057, Ldl_recept_a, 6 hits
PF00058, Ldl_recept_b, 12 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 6 hits
SM00179, EGF_CA, 4 hits
SM00192, LDLa, 7 hits
SM00135, LY, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 1 hit
SSF57424, SSF57424, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01186, EGF_2, 1 hit
PS01187, EGF_CA, 1 hit
PS01209, LDLRA_1, 4 hits
PS50068, LDLRA_2, 7 hits
PS51120, LDLRB, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B5X533-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYLTAFPFWP LVCFVWLCLG LGDLTKTAVK RNAPHYGIHP TNALGRWDWN
60 70 80 90 100
KHKQLHSDAR IGHLEAGNES REDQLSEELS KFGEKLFPVS NYPPYQQNNE
110 120 130 140 150
DSQEVHHSGE GRLHTMESSV PSKTRISGGT NSNDTPKFRN IGAQRGRTEI
160 170 180 190 200
AGIRETDRIS SRGRDGFIGG PSNKQKPFRV NLAVLVQDDP SQPGETYSNC
210 220 230 240 250
QNSNESDENC NPEEDAVPNL QRDCEKTGIH VMCPRTFRCI SKYWLCDGDD
260 270 280 290 300
DCGDYSDETH CGARTNCTDD QFECLNGFCI PRTWVCDGEN DCKDFSDETH
310 320 330 340 350
CNRTTCTDEH FTCNDGYCIS LAFRCDGEHD CNDNSDELKC AAVINSCPEG
360 370 380 390 400
EFKCRGGLGG AGGPSGQCIL NRFRCDGDND CGDWSDEENC PQKPSLCTSN
410 420 430 440 450
EYKCADGTCI PKRWKCDKEQ DCDGGEDEND CGSLGSEHPL TCGSDEFTCN
460 470 480 490 500
NGRCILKTWL CDGYPDCAAG EDEVECHLQC DLGQFLCPTK QNLTNLKICV
510 520 530 540 550
HQKHICDGHN ECPAGEDEAD CPKERKCSEP SPCEQLCIET TAGSNECACR
560 570 580 590 600
LGYVMDKNKV NCTDIDECQY LTSPVCSQKC HNTMGSFKCS CETGYILRPD
610 620 630 640 650
LRSCKALGGA MTLLVANRWD IRRVTLSNNR YSAIVKGLHN AIALDFHHRK
660 670 680 690 700
GLMFWSDVST DVIKMVYMNG TRVRDVIKWG LESPGGIAVD WIHDLLFWTD
710 720 730 740 750
SGTRRVEVSN FQGNLRTVIA SYDLDKPRAI VVHPGEALAF WSDWGPNPKI
760 770 780 790 800
ERAYMDGTQR KVIISKGVTW PNGLAIDFPN SKIYWADAKQ HAIECSNLDG
810 820 830 840 850
SDRNKILSTH LPHPFALTLF EDTMYWTDWN TKTVSAADKI TGKEFRAVHE
860 870 880 890 900
NFHFPMDIHA YHPARQPEYA DRCQKDRRGL RGGCSHLCLP NKTSRRCGCP
910 920 930 940 950
IGLSLKEDGK TCKSTADKLV LVARRKDIRL RHLRDNQADP NDVDMIVPLD
960 970 980 990 1000
NLKHAVALDW CSDTDFIYWT DVERSTINKA HLNGSYQQRV VHSNLVSPVG
1010 1020 1030 1040 1050
LALDWITDKL YWTDPSTNRI EVATTNGKMR TLLIWEKLYK PRDIVVNPIE
1060 1070 1080 1090 1100
GFMFWSDWGD DPMIERANMD GHERVTITSK KLIYPNGLAI DYEKSKIYFV
1110 1120 1130 1140 1150
DGGTKTLENM NFDGSGRQVI LNGLGHPFGL DVNEGRVFWT DWDTKSVMSA
1160 1170 1180 1190 1200
NKLTGKDTNV IIANSTDLMD IRVFHRTRRR IFNACDKLNG GCSHLCLLNP
1210 1220 1230 1240 1250
TSYTCACTVG VQLKEDRHTC SEGPTQYILF AHRIDIRQIS LDFDHLIDVV
1260 1270 1280 1290 1300
LPLPPISNAV ALDVDRKTGY IYWSDTIENV IMSSSPDGLH VQKIVGDSLE
1310 1320 1330 1340 1350
NPDGLVVDSI GRTIYWADAG RHTIEVASLD GSNRHVIAYK DLESPRGLAL
1360 1370 1380 1390 1400
DYEAGLLFWT DWGHYRKIER SHLDGNERSR IVTANLGWPN GLSLDLKSKR
1410 1420 1430 1440 1450
IYWVDARLKT IDSCDYTGNQ RKLIMSSLHH PYALALSDDN IYWTDWKSKA
1460 1470 1480 1490 1500
LHMTERRNIS AKRDIITNID GLMDIKIIYQ NQNQSTMKNA CGNNNGNCSH
1510 1520 1530 1540 1550
LCLRNPSGYS CQCPIGLRLR QNSTTQCQNL PEDYLLIALR SGIGMISLNS
1560 1570 1580 1590 1600
GDFMDVVLPI NGVHGAVVLD YHYRKNLLFF ADVNLDVIRR VNLLNLTESK
1610 1620 1630 1640 1650
VIVGTDVLTP NGIAVDWIAD NLYWSDTDRK LIEVSRLDGS CRKRIVEDNL
1660 1670 1680 1690 1700
GDPRSLIVHP KKAYLFWSDW SSPAKIERSY LDGSNRTVII TSGIGFPTGL
1710 1720 1730 1740 1750
TIDFTNRRLL WADALEDNIG QVDFNGKRRQ TIVPYAPHPF GLTLFENSIF
1760 1770 1780 1790 1800
WTDWYNKSVY RSQKLARSGY GNPFEVRDAL SGALDIRAVS LSRQPKSVNH
1810 1820 1830 1840 1850
CAQDNGGCTH LCLNRNVDYV CACPDVMDPK DVACSIKPKV LVHANLENDQ
1860 1870 1880 1890 1900
LLEYSDESTD DSTPPELLGE SNDHGDDGHT KKSDQEREFF VLVALGVVIV
1910 1920 1930 1940 1950
MVVIIILVIF MLAFNTSKKK NKRNSRGSSR SVLTFSNPNY NVDGTPMEPK
1960 1970 1980 1990 2000
TNIWKRFKYD KTHERAGVYE ERSLTTETAS SSLFVPTPSP MASPSTKTIQ

LTTLSTIT
Length:2,008
Mass (Da):225,767
Last modified:November 25, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF1C10D544BDD0A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9VXM0Q9VXM0_DROME
LDL receptor related protein 4, iso...
Lrp4 CT25574, Dm CG8909, Dmel\CG8909, LRP4, lrp4
2,009Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BT046152 mRNA Translation: ACI46540.1
AE014298 Genomic DNA Translation: ACZ95304.1
AE014298 Genomic DNA Translation: AHN59777.1

NCBI Reference Sequences

More...
RefSeqi
NP_001162769.1, NM_001169298.2
NP_001285307.1, NM_001298378.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0301666; FBpp0290880; FBgn0030706
FBtr0340309; FBpp0309270; FBgn0030706

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32552

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8909

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT046152 mRNA Translation: ACI46540.1
AE014298 Genomic DNA Translation: ACZ95304.1
AE014298 Genomic DNA Translation: AHN59777.1
RefSeqiNP_001162769.1, NM_001169298.2
NP_001285307.1, NM_001298378.1

3D structure databases

SMRiB5X533
ModBaseiSearch...

Protein-protein interaction databases

IntActiB5X533, 85 interactors

Proteomic databases

PRIDEiB5X533

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
32552

Genome annotation databases

EnsemblMetazoaiFBtr0301666; FBpp0290880; FBgn0030706
FBtr0340309; FBpp0309270; FBgn0030706
GeneIDi32552
KEGGidme:Dmel_CG8909

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4038
FlyBaseiFBgn0030706, Lrp4
VEuPathDBiVectorBase:FBgn0030706

Phylogenomic databases

GeneTreeiENSGT00940000158366
HOGENOMiCLU_000085_4_1_1
OrthoDBi121310at2759
PhylomeDBiB5X533

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
32552, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32552

Gene expression databases

BgeeiFBgn0030706, Expressed in head and 23 other tissues
ExpressionAtlasiB5X533, baseline and differential

Family and domain databases

CDDicd00112, LDLa, 6 hits
Gene3Di2.120.10.30, 4 hits
4.10.400.10, 7 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF07645, EGF_CA, 1 hit
PF00057, Ldl_recept_a, 6 hits
PF00058, Ldl_recept_b, 12 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 6 hits
SM00179, EGF_CA, 4 hits
SM00192, LDLa, 7 hits
SM00135, LY, 20 hits
SUPFAMiSSF57184, SSF57184, 1 hit
SSF57424, SSF57424, 6 hits
PROSITEiView protein in PROSITE
PS01186, EGF_2, 1 hit
PS01187, EGF_CA, 1 hit
PS01209, LDLRA_1, 4 hits
PS50068, LDLRA_2, 7 hits
PS51120, LDLRB, 15 hits

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB5X533_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B5X533
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: September 29, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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