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Protein

Dihydroorotate dehydrogenase (fumarate)

Gene

AWRI1631_110080

Organism
Saccharomyces cerevisiae (strain AWRI1631) (Baker's yeast)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(S)-dihydroorotate + fumarate = orotate + succinate.UniRule annotation

Cofactori

FMNUniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in the pathway UMP biosynthesis via de novo pathway, which is part of Pyrimidine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processPyrimidine biosynthesisUniRule annotation
LigandFlavoprotein, FMNUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00070

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (fumarate)UniRule annotation (EC:1.3.98.1UniRule annotation)
Alternative name(s):
Dihydroorotate oxidaseUniRule annotation
Gene namesi
ORF Names:AWRI1631_110080Imported
OrganismiSaccharomyces cerevisiae (strain AWRI1631) (Baker's yeast)Imported
Taxonomic identifieri545124 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000008988 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB5VLU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 296DHO_dhInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

OrthoDBiEOG092C37TJ

Family and domain databases

CDDicd04741 DHOD_1A_like, 1 hit
Gene3Di2.30.26.10, 1 hit
3.20.20.70, 1 hit
HAMAPiMF_00224 DHO_dh_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR033886 DHOD_1A
IPR023359 Dihydro_DH_chainA_dom2
IPR005720 Dihydroorotate_DH
IPR024920 Dihydroorotate_DH_1
IPR012135 Dihydroorotate_DH_1_2
IPR001295 Dihydroorotate_DH_CS
PfamiView protein in Pfam
PF01180 DHO_dh, 1 hit
PIRSFiPIRSF000164 DHO_oxidase, 1 hit
TIGRFAMsiTIGR01037 pyrD_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS00911 DHODEHASE_1, 1 hit
PS00912 DHODEHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B5VLU9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTASLTTKFL NNTYENPFMN ASGVHCMTTQ ELDELANSKA GAFITKSATT
60 70 80 90 100
LEREGNPKPR YISVPLGSIN SMGLPNEGID YYLSYVLNRQ KNYPDAPAIF
110 120 130 140 150
FSVAGMSIDE NLNLLRKIQD SEFNGITELN LSCPNVPGKP QVAYDFDLTK
160 170 180 190 200
ETLEKVFAFF KKPLGVKLPP YFDFAHFDIM AKILNEFPLA YVNSINSIGN
210 220 230 240 250
GLFIDVEKES VVVKPKNGFG GIGGEYVKPT ALANVRAFYT RLRPEIKVIG
260 270 280 290 300
TGGIKSGKDA FEHLLCGASM LQIGTELQKE GVKIFERIEK ELKDIMEAKG
310
YTSIDQFRGK LNSI
Length:314
Mass (Da):34,800
Last modified:November 25, 2008 - v1
Checksum:i0D3F59BDA26ED68E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSV01001407 Genomic DNA Translation: EDZ71096.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABSV01001407 Genomic DNA Translation: EDZ71096.1

3D structure databases

ProteinModelPortaliB5VLU9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiEOG092C37TJ

Enzyme and pathway databases

UniPathwayi
UPA00070

Family and domain databases

CDDicd04741 DHOD_1A_like, 1 hit
Gene3Di2.30.26.10, 1 hit
3.20.20.70, 1 hit
HAMAPiMF_00224 DHO_dh_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR033886 DHOD_1A
IPR023359 Dihydro_DH_chainA_dom2
IPR005720 Dihydroorotate_DH
IPR024920 Dihydroorotate_DH_1
IPR012135 Dihydroorotate_DH_1_2
IPR001295 Dihydroorotate_DH_CS
PfamiView protein in Pfam
PF01180 DHO_dh, 1 hit
PIRSFiPIRSF000164 DHO_oxidase, 1 hit
TIGRFAMsiTIGR01037 pyrD_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS00911 DHODEHASE_1, 1 hit
PS00912 DHODEHASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB5VLU9_YEAS6
AccessioniPrimary (citable) accession number: B5VLU9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 25, 2008
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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