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Entry version 71 (31 Jul 2019)
Sequence version 1 (04 Nov 2008)
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Protein

CSC1-like protein At1g11960

Gene

At1g11960

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an osmosensitive calcium-permeable cation channel.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CSC1-like protein At1g11960
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At1g11960
ORF Names:F12F1.17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G11960

The Arabidopsis Information Resource

More...
TAIRi
locus:2008860 AT1G11960

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Transmembranei512 – 532HelicalSequence analysisAdd BLAST21
Transmembranei584 – 604HelicalSequence analysisAdd BLAST21
Transmembranei630 – 650HelicalSequence analysisAdd BLAST21
Transmembranei651 – 671HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004298051 – 771CSC1-like protein At1g11960Add BLAST771

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B5TYT3

PRoteomics IDEntifications database

More...
PRIDEi
B5TYT3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B5TYT3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B5TYT3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B5TYT3 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G11960.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1134 Eukaryota
COG5594 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000241414

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B5TYT3

KEGG Orthology (KO)

More...
KOi
K21989

Identification of Orthologs from Complete Genome Data

More...
OMAi
NDYEDSR

Database of Orthologous Groups

More...
OrthoDBi
395194at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B5TYT3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032880 Csc1_N
IPR027815 PHM7_cyt
IPR003864 RSN1_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14703 PHM7_cyt, 1 hit
PF02714 RSN1_7TM, 1 hit
PF13967 RSN1_TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B5TYT3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLGDIGVA AAINILTAII FLLAFAILRI QPFNDRVYFP KWYLKGIRSS
60 70 80 90 100
PLHSGALVSK FVNVNLGSYL RFLNWMPAAL KMPEPELIDH AGLDSAVYLR
110 120 130 140 150
IYLIGLKIFV PIALLAWSIL VPVNWTSHGL QLAKLRNVTS SDIDKLSISN
160 170 180 190 200
IENGSDRFWT HLVMAYAFTF WTCYVLMKEY EKVAAMRLAF LQNEQRRPDQ
210 220 230 240 250
FTVLVRNVPA DPDESISDSV EHFFLVNHPD HYLTHQVVYN ANDLAALVEQ
260 270 280 290 300
KKSTQNWLDY YQLKYTRNQE HKPRIKTGFL GLWGKKVDAI DHYIAEIEKL
310 320 330 340 350
NEQIMEERKK VKKDDTSVMP AAFVSFKTRW GAAVSAQTQQ SSDPTEWLTE
360 370 380 390 400
WAPEAREVFW SNLAIPYVSL TVRRLIMHIA FFFLTFFFMI PIAFVQSLAS
410 420 430 440 450
IEGIEKNAPF LKSIIENDLF KSVIQGFLPG IVLKLFLIFL PSILMVMSKF
460 470 480 490 500
EGFVSLSSLE RRAAFRYYIF NLINVFLGSV ITGSAFEQLD SFLKQSAKEI
510 520 530 540 550
PKTVGVAIPI KATFFITYIM VDGWAGIAGE ILRLKPLIFF HIKNSLLVKT
560 570 580 590 600
EKDREEAMNP GQINYHATEP RIQLYFLLGL VYAPVTPVLL PFIIIFFALA
610 620 630 640 650
YLVFRHQIIN VYNQEYESAA RFWPDVHGRI ISALIIAQIL LMGLLSTKGA
660 670 680 690 700
AQSTPFLLFL PIITFFFHRY CKGRYEPAFL RHPLKEAMVK DTLERAREPN
710 720 730 740 750
FNLKPYLQKA YIHPVFKDND YEDSRFDEIS GYCIEDSDEE CVTVPTKRQS
760 770
RINTPAVSHA SRGSSRSPPS K
Length:771
Mass (Da):88,280
Last modified:November 4, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i889182EC966964D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8ANP4A0A1P8ANP4_ARATH
ERD (Early-responsive to dehydratio...
At1g11960, F12F1.17, F12F1_17
633Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC17615 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ041116 mRNA Translation: ACI01072.1
AC002131 Genomic DNA Translation: AAC17615.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28821.1
CP002684 Genomic DNA Translation: ANM58257.1

Protein sequence database of the Protein Information Resource

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PIRi
E86254

NCBI Reference Sequences

More...
RefSeqi
NP_001320706.1, NM_001332015.1
NP_172660.5, NM_101068.6

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G11960.1; AT1G11960.1; AT1G11960
AT1G11960.3; AT1G11960.3; AT1G11960

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
837748

Gramene; a comparative resource for plants

More...
Gramenei
AT1G11960.1; AT1G11960.1; AT1G11960
AT1G11960.3; AT1G11960.3; AT1G11960

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G11960

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ041116 mRNA Translation: ACI01072.1
AC002131 Genomic DNA Translation: AAC17615.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28821.1
CP002684 Genomic DNA Translation: ANM58257.1
PIRiE86254
RefSeqiNP_001320706.1, NM_001332015.1
NP_172660.5, NM_101068.6

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT1G11960.1

PTM databases

iPTMnetiB5TYT3

Proteomic databases

PaxDbiB5TYT3
PRIDEiB5TYT3

Genome annotation databases

EnsemblPlantsiAT1G11960.1; AT1G11960.1; AT1G11960
AT1G11960.3; AT1G11960.3; AT1G11960
GeneIDi837748
GrameneiAT1G11960.1; AT1G11960.1; AT1G11960
AT1G11960.3; AT1G11960.3; AT1G11960
KEGGiath:AT1G11960

Organism-specific databases

AraportiAT1G11960
TAIRilocus:2008860 AT1G11960

Phylogenomic databases

eggNOGiKOG1134 Eukaryota
COG5594 LUCA
HOGENOMiHOG000241414
InParanoidiB5TYT3
KOiK21989
OMAiNDYEDSR
OrthoDBi395194at2759
PhylomeDBiB5TYT3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:B5TYT3

Gene expression databases

ExpressionAtlasiB5TYT3 baseline and differential
GenevisibleiB5TYT3 AT

Family and domain databases

InterProiView protein in InterPro
IPR032880 Csc1_N
IPR027815 PHM7_cyt
IPR003864 RSN1_7TM
PfamiView protein in Pfam
PF14703 PHM7_cyt, 1 hit
PF02714 RSN1_7TM, 1 hit
PF13967 RSN1_TM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSCL7_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B5TYT3
Secondary accession number(s): O65383
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: November 4, 2008
Last modified: July 31, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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