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UniProtKB - B5TYJ1 (B5TYJ1_HUMAN)
Protein
Voltage-dependent P/Q-type calcium channel subunit alpha
Gene
CACNA1A
Organism
Homo sapiens (Human)
Status
Functioni
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents.
UniRule annotationGO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- voltage-gated calcium channel activity Source: InterPro
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotationARBA annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent P/Q-type calcium channel subunit alphaUniRule annotation |
Gene namesi | Name:CACNA1AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1388, CACNA1A |
VEuPathDBi | HostDB:ENSG00000141837 |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- voltage-gated calcium channel complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 102 – 119 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 139 – 159 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 222 – 245 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 337 – 359 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 488 – 507 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 519 – 539 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 614 – 636 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 690 – 714 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 1243 – 1262 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 1282 – 1303 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 1315 – 1332 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 1377 – 1399 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1489 – 1514 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 1570 – 1588 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1600 – 1623 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 1693 – 1711 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1789 – 1813 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1950 – 1984 | Ca_chan_IQInterPro annotationAdd BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 819 – 1221 | DisorderedSequence analysisAdd BLAST | 403 | |
Regioni | 1991 – 2034 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 2046 – 2263 | DisorderedSequence analysisAdd BLAST | 218 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 367 – 387 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 710 – 746 | Sequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 828 – 843 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 853 – 875 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 894 – 911 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 918 – 1034 | Basic and acidic residuesSequence analysisAdd BLAST | 117 | |
Compositional biasi | 1037 – 1054 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1115 – 1129 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1140 – 1162 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1193 – 1215 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 2046 – 2069 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 2110 – 2126 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 2137 – 2156 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 2207 – 2224 | Basic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 2225 – 2263 | Basic and acidic residuesSequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156518 |
Family and domain databases
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR005448, CACNA1A IPR031649, GPHH_dom IPR005821, Ion_trans_dom IPR014873, VDCC_a1su_IQ IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF08763, Ca_chan_IQ, 1 hit PF16905, GPHH, 1 hit PF00520, Ion_trans, 4 hits |
PRINTSi | PR00167, CACHANNEL PR01632, PQVDCCALPHA1 |
SMARTi | View protein in SMART SM01062, Ca_chan_IQ, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 22 potential isoforms that are computationally mapped.Show allAlign All
B5TYJ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARFGDEMPA RYGGGGSGAA AGVVVGSGGG RGAGGSRQGG QPGAQRMYKQ
60 70 80 90 100
SMAQRARTMA LYNPIPVRQN CLTVNRSLFL FSEDNVVRKY AKKITEWPPF
110 120 130 140 150
EYMILATIIA NCIVLALEQH LPDDDKTPMS ERLDDTEPYF IGIFCFEAGI
160 170 180 190 200
KIIALGFAFH KGSYLRNGWN VMDFVVVLTG ILATVGTEFD LRTLRAVRVL
210 220 230 240 250
RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG LLLFFAILIF AIIGLEFYMG
260 270 280 290 300
KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGITQ
310 320 330 340 350
FDNILFAVLT VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF
360 370 380 390 400
MLNLVLGVLS GEFAKERERV ENRRAFLKLR RQQQIERELN GYMEWISKAE
410 420 430 440 450
EVILAEDETD GEQRHPFDGA LRRTTIKKSK TDLLNPEEAE DQLADIASVG
460 470 480 490 500
SPFARASIKS AKLENSTFFH KKERRMRFYI RRMVKTQAFY WTVLSLVALN
510 520 530 540 550
TLCVAIVHYN QPEWLSDFLY YAEFIFLGLF MSEMFIKMYG LGTRPYFHSS
560 570 580 590 600
FNCFDCGVII GSIFEVIWAV IKPGTSFGIS VLRALRLLRI FKVTKYWASL
610 620 630 640 650
RNLVVSLLNS MKSIISLLFL LFLFIVVFAL LGMQLFGGQF NFDEGTPPTN
660 670 680 690 700
FDTFPAAIMT VFQILTGEDW NEVMYDGIKS QGGVQGGMVF SIYFIVLTLF
710 720 730 740 750
GNYTLLNVFL AIAVDNLANA QELTKDEQEE EEAANQKLAL QKAKEVAEVS
760 770 780 790 800
PLSAANMSIA VKEQQKNQKP AKSVWEQRTS EMRKQNLLAS REALYNEMDP
810 820 830 840 850
DERWKAAYTR HLRPDMKTHL DRPLVVDPQE NRNNNTNKSR AAEPTVDQRL
860 870 880 890 900
GQQRAEDFLR KQARYHDRAR DPSGSAGLDA RRPWAGSQEA ELSREGPYGR
910 920 930 940 950
ESDHHAREGS LEQPGFWEGE AERGKAGDPH RRHVHRQGGS RESRSGSPRT
960 970 980 990 1000
GADGEHRRHR AHRRPGEEGP EDKAERRARH REGSRPARGG EGEGEGPDGG
1010 1020 1030 1040 1050
ERRRRHRHGA PATYEGDARR EDKERRHRRR KENQGSGVPV SGPNLSTTRP
1060 1070 1080 1090 1100
IQQDLGRQDP PLAEDIDNMK NNKLATAESA APHGSLGHAG LPQSPAKMGN
1110 1120 1130 1140 1150
STDPGPMLAI PAMATNPQNA ASRRTPNNPG NPSNPGPPKT PENSLIVTNP
1160 1170 1180 1190 1200
SGTQTNSAKT ARKPDHTTVD IPPACPPPLN HTVVQVNKNA NPDPLPKKEE
1210 1220 1230 1240 1250
EKKEEEEDDR GEDGPKPMPP YSSMFILSTT NPLRRLCHYI LNLRYFEMCI
1260 1270 1280 1290 1300
LMVIAMSSIA LAAEDPVQPN APRNNVLRYF DYVFTGVFTF EMVIKMIDLG
1310 1320 1330 1340 1350
LVLHQGAYFR DLWNILDFIV VSGALVAFAF TGNSKGKDIN TIKSLRVLRV
1360 1370 1380 1390 1400
LRPLKTIKRL PKLKAVFDCV VNSLKNVFNI LIVYMLFMFI FAVVAVQLFK
1410 1420 1430 1440 1450
GKFFHCTDES KEFEKDCRGK YLLYEKNEVK ARDREWKKYE FHYDNVLWAL
1460 1470 1480 1490 1500
LTLFTVSTGE GWPQVLKHSV DATFENQGPS PGYRMEMSIF YVVYFVVFPF
1510 1520 1530 1540 1550
FFVNIFVALI IITFQEQGDK MMEEYSLEKN ERACIDFAIS AKPLTRHMPQ
1560 1570 1580 1590 1600
NKQSFQYRMW QFVVSPPFEY TIMAMIALNT IVLMMKFYGA SVAYENALRV
1610 1620 1630 1640 1650
FNIVFTSLFS LECVLKVMAF GILNYFRDAW NIFDFVTVLG SITDILVTEF
1660 1670 1680 1690 1700
GNPNNFINLS FLRLFRAARL IKLLRQGYTI RILLWTFVQS FKALPYVCLL
1710 1720 1730 1740 1750
IAMLFFIYAI IGMQVFGNIG IDVEDEDSDE DEFQITEHNN FRTFFQALML
1760 1770 1780 1790 1800
LFRSATGEAW HNIMLSCLSG KPCDKNSGIL TRECGNEFAY FYFVSFIFLC
1810 1820 1830 1840 1850
SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LDEYVRVWAE YDPAAWGRMP
1860 1870 1880 1890 1900
YLDMYQMLRH MSPPLGLGKK CPARVAYKRL LRMDLPVADD NTVHFNSTLM
1910 1920 1930 1940 1950
ALIRTALDIK IAKGGADKQQ MDAELRKEMM AIWPNLSQKT LDLLVTPHKS
1960 1970 1980 1990 2000
TDLTVGKIYA AMMIMEYYRQ SKAKKLQAMR EEQDRTPLMF QRMEPPSPTQ
2010 2020 2030 2040 2050
EGGPGQNALP STQLDPGGAL MAHESGLKES PSWVTQRAQE MFQKTGTWSP
2060 2070 2080 2090 2100
EQGPPTDMPN SQPNSQSVEM REMGRDGYSD SEHYLPMEGQ GRAASMPRLP
2110 2120 2130 2140 2150
AENQRRRGRP RGNNLSTISD TSPMKRSASV LGPKARRLDD YSLERVPPEE
2160 2170 2180 2190 2200
NQRHHQRRRD RSHRASERSL GRYTDVDTGL GTDLSMTTQS GDLPSKERDQ
2210 2220 2230 2240 2250
ERGRPKDRKH RQHHHHHHHH HHPPPPDKDR YAQERPDHGR ARARDQRWSR
2260
SPSEGREHMA HRQ
Computationally mapped potential isoform sequencesi
There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO00555 | CAC1A_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A CACH4, CACN3, CACNL1A4 | 2,506 | Annotation score: | ||
A0A087WW63 | A0A087WW63_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,512 | Annotation score: | ||
A0A384DVW2 | A0A384DVW2_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,261 | Annotation score: | ||
A0A1B0GTI4 | A0A1B0GTI4_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,262 | Annotation score: | ||
A0A1B0GTN7 | A0A1B0GTN7_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,507 | Annotation score: | ||
A0A1B0GTW2 | A0A1B0GTW2_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,460 | Annotation score: | ||
A0A1B0GU74 | A0A1B0GU74_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,302 | Annotation score: | ||
A0A1B0GUS3 | A0A1B0GUS3_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,495 | Annotation score: | ||
A0A1C7CYY9 | A0A1C7CYY9_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,508 | Annotation score: | ||
A0A1B0GU81 | A0A1B0GU81_HUMAN | Voltage-dependent P/Q-type calcium ... | CACNA1A | 2,507 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005305 Genomic DNA No translation available. AC005513 Genomic DNA No translation available. AC011446 Genomic DNA No translation available. AC022436 Genomic DNA No translation available. AC026805 Genomic DNA No translation available. AC093062 Genomic DNA No translation available. AC098781 Genomic DNA No translation available. AC124224 Genomic DNA No translation available. KF456505 Genomic DNA No translation available. FJ040507 mRNA Translation: ACH89974.1 |
RefSeqi | NP_001167551.1, NM_001174080.1 |
Genome annotation databases
Ensembli | ENST00000636549.1; ENSP00000490578.1; ENSG00000141837.22 |
GeneIDi | 773 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005305 Genomic DNA No translation available. AC005513 Genomic DNA No translation available. AC011446 Genomic DNA No translation available. AC022436 Genomic DNA No translation available. AC026805 Genomic DNA No translation available. AC093062 Genomic DNA No translation available. AC098781 Genomic DNA No translation available. AC124224 Genomic DNA No translation available. KF456505 Genomic DNA No translation available. FJ040507 mRNA Translation: ACH89974.1 |
RefSeqi | NP_001167551.1, NM_001174080.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 26386, 93 antibodies from 22 providers |
DNASUi | 773 |
Genome annotation databases
Ensembli | ENST00000636549.1; ENSP00000490578.1; ENSG00000141837.22 |
GeneIDi | 773 |
Organism-specific databases
CTDi | 773 |
HGNCi | HGNC:1388, CACNA1A |
OpenTargetsi | ENSG00000141837 |
PharmGKBi | PA26007 |
VEuPathDBi | HostDB:ENSG00000141837 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156518 |
Miscellaneous databases
BioGRID-ORCSi | 773, 18 hits in 1077 CRISPR screens |
ChiTaRSi | CACNA1A, human |
GenomeRNAii | 773 |
Gene expression databases
Genevisiblei | B5TYJ1, HS |
Family and domain databases
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR005448, CACNA1A IPR031649, GPHH_dom IPR005821, Ion_trans_dom IPR014873, VDCC_a1su_IQ IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF08763, Ca_chan_IQ, 1 hit PF16905, GPHH, 1 hit PF00520, Ion_trans, 4 hits |
PRINTSi | PR00167, CACHANNEL PR01632, PQVDCCALPHA1 |
SMARTi | View protein in SMART SM01062, Ca_chan_IQ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B5TYJ1_HUMAN | |
Accessioni | B5TYJ1Primary (citable) accession number: B5TYJ1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 4, 2008 |
Last sequence update: | November 4, 2008 | |
Last modified: | May 25, 2022 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |