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Entry version 52 (02 Jun 2021)
Sequence version 1 (04 Nov 2008)
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Protein

Anoctamin

Gene

ano1.L

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.17.1.28, the calcium-dependent chloride channel (ca-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AnoctaminUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ano1.LImported
Synonyms:ano1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-6029976, ano1.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei326 – 350HelicalUniRule annotationAdd BLAST25
Transmembranei403 – 422HelicalUniRule annotationAdd BLAST20
Transmembranei511 – 537HelicalUniRule annotationAdd BLAST27
Transmembranei557 – 581HelicalUniRule annotationAdd BLAST25
Transmembranei601 – 622HelicalUniRule annotationAdd BLAST22
Transmembranei727 – 754HelicalUniRule annotationAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B5SVV6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 312Anoct_dimerInterPro annotationAdd BLAST262

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni71 – 106DisorderedSequence analysisAdd BLAST36
Regioni948 – 979DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi86 – 106Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi954 – 979Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anoctamin family.UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1263362at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032394, Anoct_dimer
IPR007632, Anoctamin
IPR031287, Anoctamin-1

The PANTHER Classification System

More...
PANTHERi
PTHR12308, PTHR12308, 1 hit
PTHR12308:SF13, PTHR12308:SF13, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16178, Anoct_dimer, 1 hit
PF04547, Anoctamin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B5SVV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIMAAKLDER VHEAPIPMNN INMDLLSQVG LTNLLNSLGA DRETGCKHGI
60 70 80 90 100
FFKDGQRKVD YILAFTYKKS GSRTPNKKNH HNNSVHNLHS PKDDHHLPGG
110 120 130 140 150
GGDLEAMEAE PKMDYHEDDK RFRREEYEGN LIETGLELER DEETKLHGVG
160 170 180 190 200
FVKIHAPWNV LCREAEFMKL KMPTKKVYQI NQTQGLMQKL SSFIHKISEP
210 220 230 240 250
IQPKVAGLRP QTVKHLSYPF SREKQHLFDM SDKESFFDSK TRSSIVYEIL
260 270 280 290 300
KRTTCTKAKY SMGITSLLAN GVYSAAYPLH DGDYDSEAEA NDRKLLSDEW
310 320 330 340 350
ASYSAFYKYQ PIDLVRKYFG EKIGLYFAWL GVYTQMLIPA SVVGIIVFLY
360 370 380 390 400
GCATVDENIP SMEMCDTRYN ITMCPLCDRT CNYWKMSSAC GTARASHLFD
410 420 430 440 450
NPATVFFSVF MALWAASFME HWKRRQMRLN YRWDLTGFEE EEGMVKDHPR
460 470 480 490 500
AEYEAKVLQK SLKKEYRSKE KQQHVPEDNP NKWKQRVKTA MAGVKLTEKE
510 520 530 540 550
KLTWRDRFPA YLTNVVGIIF MIGVTFAIVF GVIMYRISTA AALAMSSNPN
560 570 580 590 600
TRANVRVTVT ATAVIINLVV ILILDEVYGA IARWLTQIEV PKTDKTFEER
610 620 630 640 650
LIFKAFLLKF VNAYTPIFYV AFFKGRIVGR PGDYYYIFQS FRMEECAPGG
660 670 680 690 700
CLMELCIQLS IIMLGKQLIQ NNLFEIGIPK MKKLIRYLKS KRQSYKDHEE
710 720 730 740 750
HLKKKQRYEE DYDLEPFAGL TPEYMEMIIQ FGFVTLFVAS FPLAPLFALL
760 770 780 790 800
NNIIEIRLDA KKFITELRRP VAVRAKDIGI WYNIIRGVGK LAVIINAFVI
810 820 830 840 850
SFTSDFIPRL VYLYMYSPDG TMHGFVNHTL SYFNVSDFKL GTEPSQPVDL
860 870 880 890 900
GYKVEMCRYK DYREAPWSLN KYDINKDYWA VLAARLAFVI VFQNLVMFMS
910 920 930 940 950
DFVDWIIPDI PKDISEQIHR EKVLMVEVFL KEEQGKLQML ETWKEHERKK
960 970
GENCNSQSPG LSRSQRGSSS SMYSHRVDV
Length:979
Mass (Da):113,226
Last modified:November 4, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADD41C44BC0C5587
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU367938 mRNA Translation: ACA63032.1

NCBI Reference Sequences

More...
RefSeqi
NP_001128709.1, NM_001135237.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100190795

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:100190795

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU367938 mRNA Translation: ACA63032.1
RefSeqiNP_001128709.1, NM_001135237.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.17.1.28, the calcium-dependent chloride channel (ca-clc) family

Proteomic databases

MaxQBiB5SVV6

Genome annotation databases

GeneIDi100190795
KEGGixla:100190795

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100190795
XenbaseiXB-GENE-6029976, ano1.L

Phylogenomic databases

OrthoDBi1263362at2759

Family and domain databases

InterProiView protein in InterPro
IPR032394, Anoct_dimer
IPR007632, Anoctamin
IPR031287, Anoctamin-1
PANTHERiPTHR12308, PTHR12308, 1 hit
PTHR12308:SF13, PTHR12308:SF13, 1 hit
PfamiView protein in Pfam
PF16178, Anoct_dimer, 1 hit
PF04547, Anoctamin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB5SVV6_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B5SVV6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 4, 2008
Last sequence update: November 4, 2008
Last modified: June 2, 2021
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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