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Protein
Submitted name:

Septin 10, isoform CRA_c

Gene

SEPT10

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Septin 10, isoform CRA_cImported
Submitted name:
Septin-10Imported
Gene namesi
Name:SEPT10Imported
ORF Names:hCG_27895Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000186522.14
HGNCiHGNC:14349 SEPT10

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186522

PTM / Processingi

Proteomic databases

EPDiB5ME97
MaxQBiB5ME97
PRIDEiB5ME97

Expressioni

Gene expression databases

BgeeiENSG00000186522 Expressed in 239 organ(s), highest expression level in mouth mucosa
ExpressionAtlasiB5ME97 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiB5ME97, 2 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 329Septin-type GInterPro annotationAdd BLAST267

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili367 – 423Sequence analysisAdd BLAST57

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOGENOMiHOG000233586
HOVERGENiHBG065093
OMAiMDLVCMK
OrthoDBiEOG091G0IKM

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

B5ME97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSEVARHL LFQSHMATKT TCMSSQGSDD EQIKRENIRS LTMSGHVGFE
60 70 80 90 100
SLPDQLVNRS IQQGFCFNIL CVGETGIGKS TLIDTLFNTN FEDYESSHFC
110 120 130 140 150
PNVKLKAQTY ELQESNVQLK LTIVNTVGFG DQINKEESYQ PIVDYIDAQF
160 170 180 190 200
EAYLQEELKI KRSLFTYHDS RIHVCLYFIS PTGHSLKTLD LLTMKNLDSK
210 220 230 240 250
VNIIPVIAKA DTVSKTELQK FKIKLMSELV SNGVQIYQFP TDDDTIAKVN
260 270 280 290 300
AAMNGQLPFA VVGSMDEVKV GNKMVKARQY PWGVVQVENE NHCDFVKLRE
310 320 330 340 350
MLICTNMEDL REQTHTRHYE LYRRCKLEEM GFTDVGPENK PVSVQETYEA
360 370 380 390 400
KRHEFHGERQ RKEEEMKQMF VQRVKEKEAI LKEAERELQA KFEHLKRLHQ
410 420 430 440 450
EERMKLEEKR RLLEEEIIAF SKKKATSEIF HSQSFLATGS NLRKDKDRKK
460 470 480 490 500
EPGCRFELLC IDVRACETNG GRKDAEKAPI FCKTEVPEHR RSSSQANFIK
510 520 530 540
KKLEVCFDFA VICFITSIFG EQPQLLIFME KYFQVQGQYI SQSE
Length:544
Mass (Da):62,945
Last modified:November 3, 2009 - v2
Checksum:iD6629AAC295DCAA3
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9P0V9SEP10_HUMAN
Septin-10
SEPT10
454Annotation score:
E7EW69E7EW69_HUMAN
Septin-10
SEPT10
450Annotation score:
E7EX04E7EX04_HUMAN
Septin-10
SEPT10
473Annotation score:
F5H1F2F5H1F2_HUMAN
Septin-10
SEPT10
98Annotation score:
C9JEQ7C9JEQ7_HUMAN
Septin-10
SEPT10
97Annotation score:
F5GYV2F5GYV2_HUMAN
Septin-10
SEPT10
26Annotation score:
C9JNR7C9JNR7_HUMAN
Septin-10
SEPT10
61Annotation score:
F8WC85F8WC85_HUMAN
Septin-10
SEPT10
48Annotation score:
C9JEW2C9JEW2_HUMAN
Septin-10
SEPT10
57Annotation score:
F5H1W3F5H1W3_HUMAN
Septin-10
SEPT10
38Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011753 Genomic DNA No translation available.
AC140485 Genomic DNA No translation available.
CH471182 Genomic DNA Translation: EAW53860.1
RefSeqiNP_001308427.1, NM_001321498.1
UniGeneiHs.469615

Genome annotation databases

EnsembliENST00000356688; ENSP00000349116; ENSG00000186522
GeneIDi151011
UCSCiuc002tey.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011753 Genomic DNA No translation available.
AC140485 Genomic DNA No translation available.
CH471182 Genomic DNA Translation: EAW53860.1
RefSeqiNP_001308427.1, NM_001321498.1
UniGeneiHs.469615

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB5ME97, 2 interactors

Proteomic databases

EPDiB5ME97
MaxQBiB5ME97
PRIDEiB5ME97

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356688; ENSP00000349116; ENSG00000186522
GeneIDi151011
UCSCiuc002tey.5 human

Organism-specific databases

CTDi151011
EuPathDBiHostDB:ENSG00000186522.14
HGNCiHGNC:14349 SEPT10
OpenTargetsiENSG00000186522
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOGENOMiHOG000233586
HOVERGENiHBG065093
OMAiMDLVCMK
OrthoDBiEOG091G0IKM

Miscellaneous databases

ChiTaRSiSEPT10 human
GenomeRNAii151011

Gene expression databases

BgeeiENSG00000186522 Expressed in 239 organ(s), highest expression level in mouth mucosa
ExpressionAtlasiB5ME97 baseline and differential

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB5ME97_HUMAN
AccessioniPrimary (citable) accession number: B5ME97
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: November 3, 2009
Last modified: November 7, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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