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Entry version 72 (08 May 2019)
Sequence version 1 (14 Oct 2008)
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Protein

Tudor domain-containing protein 15

Gene

TDRD15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tudor domain-containing protein 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TDRD15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:45037 TDRD15

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_B5MCY1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000218819

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TDRD15

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004219651 – 1934Tudor domain-containing protein 15Add BLAST1934

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
B5MCY1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
B5MCY1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B5MCY1

PRoteomics IDEntifications database

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PRIDEi
B5MCY1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
6126

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B5MCY1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B5MCY1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000218819 Expressed in 5 organ(s), highest expression level in testis

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051770
HPA054675

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384376

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
B5MCY1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 117Tudor 1PROSITE-ProRule annotationAdd BLAST59
Domaini289 – 347Tudor 2PROSITE-ProRule annotationAdd BLAST59
Domaini531 – 589Tudor 3PROSITE-ProRule annotationAdd BLAST59
Domaini799 – 856Tudor 4PROSITE-ProRule annotationAdd BLAST58
Domaini1011 – 1070Tudor 5PROSITE-ProRule annotationAdd BLAST60
Domaini1342 – 1401Tudor 6PROSITE-ProRule annotationAdd BLAST60
Domaini1574 – 1633Tudor 7PROSITE-ProRule annotationAdd BLAST60
Domaini1780 – 1838Tudor 8PROSITE-ProRule annotationAdd BLAST59

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2039 Eukaryota
COG1525 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162581

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074132

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B5MCY1

KEGG Orthology (KO)

More...
KOi
K18405

Identification of Orthologs from Complete Genome Data

More...
OMAi
RLSYPCI

Database of Orthologous Groups

More...
OrthoDBi
496838at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B5MCY1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.90, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035437 SNase_OB-fold_sf
IPR002999 Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00567 TUDOR, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00333 TUDOR, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50304 TUDOR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B5MCY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSTSFLPTF LDVDLTISHI KCLPKDILVK FQGIKSNECE FDYHVLQREI
60 70 80 90 100
QHTPKVKNNV EIDEFCLVEE RVSGEWQRGR VMEKKNELYT VLLIDRGEEL
110 120 130 140 150
RVAGPQIASA CGNLFELPPR VVFGIFANIL PVGEKWSPKA LNYFKSLVGI
160 170 180 190 200
QVKGYVQAIL PLQMFLFEVP KIISQALELQ LGRLVDGDSF RLIVEMLEEF
210 220 230 240 250
PQQMPDLLQH KRPELSLGNK DTSLDIQHVL DKLQPSLSVG STESVKVSSA
260 270 280 290 300
LSPSKFYCQL IKWTPELENL TAHMTLHYDT VCQETSPTCD NFGLLCVARR
310 320 330 340 350
RNGQWHRGIL QQLLPPNQVK IWFMDYGSSE AIPSIYVKKL KQDFILVPLF
360 370 380 390 400
SFPCSLTCLH SPDRDARIFQ LSIFKQALLG QVVYAHIDWF NKDECLYYVT
410 420 430 440 450
LQTQESTVNS KCLLKTVGTQ VLCPMSDSKI SNILSETSVS DVNSFAVESF
460 470 480 490 500
MGNIEWSIDS LNKKGILKVG FPIKTVQMEI EAAYIAFIAY VLNPSNFWVR
510 520 530 540 550
TNDHRNEFQE IMKNINKFYD LCENDEMILR KPEPGLFCCA RYSKDRRFYR
560 570 580 590 600
AVITEINGYK INVYFLDYGN TDSIPFFDVK ILLPEFCELP ALAMCCSLAH
610 620 630 640 650
IFPVEDLWTK AAIDYFKKLV LNKAILLQVI AKKDDKYTVN IQSVEASENI
660 670 680 690 700
DVISLMLQAG YAEYFQVELE YFPKSVSEYS MLNSESKNKV NIKKVISALL
710 720 730 740 750
EGPKSKKYHS NNLVENNLSL PKSLAVNISE FKNPFTLSVG PESSWPYKEY
760 770 780 790 800
IFRPGTVLEV KCSCYYGPGD FSCQLQCKSE DLKLLMEQIQ NYYSIHSDPY
810 820 830 840 850
EIGQTACVAK YSGKWCRAAV LTQVSKEVDI VFVDYGYQKR VLIEDLCAIN
860 870 880 890 900
PRFLLLESQA FRCCLNHFIE PVSCKLFSWT RKAFRDLWNF ISSSRGLLTC
910 920 930 940 950
IIYALVIIHP NHLYNLVDLQ SSFTSAKEFL MNRGSAQYIT LSETFPSLFS
960 970 980 990 1000
LYSYCYSSFN IQIGSEEEVY ISHIYSPQKF YCQLGRNNKD LEMIETKITE
1010 1020 1030 1040 1050
SVNLQNFPKY DSNKMRVCIS KYVEDGLSYR ALAIPTDSSS EFQVYFVDFG
1060 1070 1080 1090 1100
NKQLVGENML RAISAQFPEL LFTPMQAIKC FLSDLRDVDI PAEISSWFKD
1110 1120 1130 1140 1150
NFLGRSLKAI ILSQESDGQL GIELYDGSQY INEKIKVLLH AYGKRHCDQA
1160 1170 1180 1190 1200
CCMEKSNKIN ENKRFTTSLK GKTGNNYRHN VINKPSPVTY SERKIDQLMH
1210 1220 1230 1240 1250
PKNIHARFLK PSVCYKMEPV SKNKMKTSLN DGLKGIKIVP GAAHILENRR
1260 1270 1280 1290 1300
VGQKSVKVVS QSFIRALNQT TSQNPYDLIR PQIKDLPQPQ IYLNAKVKGY
1310 1320 1330 1340 1350
VSNISNPANF HIQLAENESV IIRLADALNA TARRLRERKS VKPLVGDLVV
1360 1370 1380 1390 1400
AEYSGDNAIY RAVIKKILPG NSFEVEFIDY GNSAIVNTSK IYELQREFLT
1410 1420 1430 1440 1450
VPQLGIHAFL SGVKWNEPDE IWDDKTVDYF TSKVHNKTVY CEFLKKHDQK
1460 1470 1480 1490 1500
WEVNMICDEK CVINELLKWK ACSKLQKSAL QMPQVLSQKV RPGDNEMKKG
1510 1520 1530 1540 1550
KSNESEGSMN SNQQLFKIPL EEFKLGQLEK AEMLNVSKSG RFYVKLSKNK
1560 1570 1580 1590 1600
KILSDLIVLI TKEEKKSPFL SMESIEKGLE CLAKSKNTLK WHRSKVEEKY
1610 1620 1630 1640 1650
VDDKVLVFLV DCGIYEIVPV CNTKLLSNEI RNIPRQAVPC KWIWFENSKN
1660 1670 1680 1690 1700
ISFECLFADL EINILFLKYL DAVWEVEILV DDLLLLEYLN LNTVPVEENK
1710 1720 1730 1740 1750
LRLAEIVYNI ESKTPVSSCT IKSFTWVQFQ NDRQYSGIAT AVSDPSDFSI
1760 1770 1780 1790 1800
QLEDFFDIMK YLFMLLSDLP ETLQTLPQEF IIPGSSCLFK YKSEDQWNRV
1810 1820 1830 1840 1850
EISEVSPQSL CLVLVDYGFS FYIRYSEIIN LKVVPEELLN LPRLSYPCIL
1860 1870 1880 1890 1900
YGILPAKGKH WSEEAKIFFR DFLSKPDLVF QFREYHSETK LKVDVIHEKN
1910 1920 1930
NLADILVASG LATYSKDSPH LDAITATESA KNPI
Length:1,934
Mass (Da):221,722
Last modified:October 14, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51FCD0252E2D0C29
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010872 Genomic DNA No translation available.
EG328743 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS77385.1

NCBI Reference Sequences

More...
RefSeqi
NP_001293066.1, NM_001306137.1
XP_011531514.1, XM_011533212.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000405799; ENSP00000384376; ENSG00000218819
ENST00000622654; ENSP00000478350; ENSG00000218819

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100129278

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:100129278

UCSC genome browser

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UCSCi
uc061gzs.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010872 Genomic DNA No translation available.
EG328743 mRNA No translation available.
CCDSiCCDS77385.1
RefSeqiNP_001293066.1, NM_001306137.1
XP_011531514.1, XM_011533212.1

3D structure databases

SMRiB5MCY1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000384376

PTM databases

iPTMnetiB5MCY1
PhosphoSitePlusiB5MCY1

Polymorphism and mutation databases

BioMutaiTDRD15

Proteomic databases

EPDiB5MCY1
jPOSTiB5MCY1
PaxDbiB5MCY1
PRIDEiB5MCY1
ProteomicsDBi6126

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405799; ENSP00000384376; ENSG00000218819
ENST00000622654; ENSP00000478350; ENSG00000218819
GeneIDi100129278
KEGGihsa:100129278
UCSCiuc061gzs.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100129278

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TDRD15
HGNCiHGNC:45037 TDRD15
HPAiHPA051770
HPA054675
neXtProtiNX_B5MCY1
OpenTargetsiENSG00000218819

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2039 Eukaryota
COG1525 LUCA
GeneTreeiENSGT00940000162581
HOGENOMiHOG000074132
InParanoidiB5MCY1
KOiK18405
OMAiRLSYPCI
OrthoDBi496838at2759
PhylomeDBiB5MCY1

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
100129278

Protein Ontology

More...
PROi
PR:B5MCY1

Gene expression databases

BgeeiENSG00000218819 Expressed in 5 organ(s), highest expression level in testis

Family and domain databases

Gene3Di2.40.50.90, 5 hits
InterProiView protein in InterPro
IPR035437 SNase_OB-fold_sf
IPR002999 Tudor
PfamiView protein in Pfam
PF00567 TUDOR, 8 hits
SMARTiView protein in SMART
SM00333 TUDOR, 8 hits
PROSITEiView protein in PROSITE
PS50304 TUDOR, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTDR15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B5MCY1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2013
Last sequence update: October 14, 2008
Last modified: May 8, 2019
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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