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UniProtKB - B5MCV2 (B5MCV2_HUMAN)
Protein
Submitted name:
D-2-hydroxyglutarate dehydrogenase, mitochondrial
Gene
D2HGDH
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
FADARBA annotation
GO - Molecular functioni
- FAD binding Source: InterPro
- oxidoreductase activity Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: D-2-hydroxyglutarate dehydrogenase, mitochondrialImported |
Gene namesi | Name:D2HGDHImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28358, D2HGDH |
VEuPathDBi | HostDB:ENSG00000180902 |
PTM / Processingi
Proteomic databases
MaxQBi | B5MCV2 |
PeptideAtlasi | B5MCV2 |
PRIDEi | B5MCV2 |
ProteomicsDBi | 6108 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180902, Expressed in right uterine tube and 194 other tissues |
ExpressionAtlasi | B5MCV2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 141 | FAD-binding PCMH-typeInterPro annotationAdd BLAST | 141 |
Sequence similaritiesi
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00550000075086 |
HOGENOMi | CLU_017779_4_1_1 |
OMAi | TPRTCGE |
OrthoDBi | 515900at2759 |
Family and domain databases
Gene3Di | 1.10.45.10, 1 hit 3.30.465.10, 1 hit |
InterProi | View protein in InterPro IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016169, FAD-bd_PCMH_sub2 IPR016164, FAD-linked_Oxase-like_C IPR004113, FAD-linked_oxidase_C IPR006094, Oxid_FAD_bind_N IPR016171, Vanillyl_alc_oxidase_C-sub2 |
Pfami | View protein in Pfam PF02913, FAD-oxidase_C, 1 hit PF01565, FAD_binding_4, 1 hit |
SUPFAMi | SSF55103, SSF55103, 1 hit SSF56176, SSF56176, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
B5MCV2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVGGSVPVFD EIILSTARMN RVLSFHSVSG ILVCQAGCVL EELSRYVEER
60 70 80 90 100
DFIMPLDLGA KGSCHIGGNV ATNAGGLRFL RYGSLHGTVL GLEVVLADGT
110 120 130 140 150
VLDCLTSLRK DNTGYDLKQL FIGSEGTLGI ITTVSILCPP KPRAVNVAFL
160 170 180 190 200
GCPGFAEVLQ TFSTCKGMLG EILSAFEFMD AVCMQLVGRH LHLASPVQES
210 220 230 240 250
PFYVLIETSG SNAGHDAEKL GHFLEHALGS GLVTDGTMAT DQRKVKMLWA
260 270 280 290 300
LRERITEALS RDGYVYKYDL SLPVERLYDI VTDLRARLGP HAKHVVGYGH
310 320 330 340 350
LGDGNLHLNV TAEAFSPSLL AALEPHVYEW TAGQQGSVSA EHGVGFRKRD
360 370 380
VLGYSKPPGA LQLMQQLKAL LDPKGILNPY KTLPSQA
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8N465 | D2HDH_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH D2HGD | 521 | Annotation score: | ||
F8WCF9 | F8WCF9_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH | 243 | Annotation score: | ||
G5E9E8 | G5E9E8_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH hCG_31745 | 320 | Annotation score: | ||
H7C021 | H7C021_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH | 152 | Annotation score: | ||
H7C3L2 | H7C3L2_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH | 89 | Annotation score: | ||
H7C0N1 | H7C0N1_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH | 189 | Annotation score: | ||
H7C290 | H7C290_HUMAN | D-2-hydroxyglutarate dehydrogenase,... | D2HGDH | 78 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC114730 Genomic DNA No translation available. |
RefSeqi | NP_001274178.1, NM_001287249.1 |
Genome annotation databases
Ensembli | ENST00000403782; ENSP00000384723; ENSG00000180902 |
GeneIDi | 728294 |
UCSCi | uc010fzq.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC114730 Genomic DNA No translation available. |
RefSeqi | NP_001274178.1, NM_001287249.1 |
3D structure databases
SMRi | B5MCV2 |
ModBasei | Search... |
Proteomic databases
MaxQBi | B5MCV2 |
PeptideAtlasi | B5MCV2 |
PRIDEi | B5MCV2 |
ProteomicsDBi | 6108 |
Protocols and materials databases
Antibodypediai | 34576, 113 antibodies from 18 providers |
DNASUi | 728294 |
Genome annotation databases
Ensembli | ENST00000403782; ENSP00000384723; ENSG00000180902 |
GeneIDi | 728294 |
UCSCi | uc010fzq.3, human |
Organism-specific databases
CTDi | 728294 |
HGNCi | HGNC:28358, D2HGDH |
OpenTargetsi | ENSG00000180902 |
VEuPathDBi | HostDB:ENSG00000180902 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00550000075086 |
HOGENOMi | CLU_017779_4_1_1 |
OMAi | TPRTCGE |
OrthoDBi | 515900at2759 |
Miscellaneous databases
BioGRID-ORCSi | 728294, 5 hits in 1045 CRISPR screens |
ChiTaRSi | D2HGDH, human |
GenomeRNAii | 728294 |
Gene expression databases
Bgeei | ENSG00000180902, Expressed in right uterine tube and 194 other tissues |
ExpressionAtlasi | B5MCV2, baseline and differential |
Family and domain databases
Gene3Di | 1.10.45.10, 1 hit 3.30.465.10, 1 hit |
InterProi | View protein in InterPro IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016169, FAD-bd_PCMH_sub2 IPR016164, FAD-linked_Oxase-like_C IPR004113, FAD-linked_oxidase_C IPR006094, Oxid_FAD_bind_N IPR016171, Vanillyl_alc_oxidase_C-sub2 |
Pfami | View protein in Pfam PF02913, FAD-oxidase_C, 1 hit PF01565, FAD_binding_4, 1 hit |
SUPFAMi | SSF55103, SSF55103, 1 hit SSF56176, SSF56176, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B5MCV2_HUMAN | |
Accessioni | B5MCV2Primary (citable) accession number: B5MCV2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 14, 2008 |
Last sequence update: | October 14, 2008 | |
Last modified: | January 19, 2022 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |