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Protein

UDP-glucuronosyltransferase

Gene

UGT1A6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferaseUniRule annotation (EC:2.4.1.17UniRule annotation)
Gene namesi
Name:UGT1A6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000167165.18
HGNCiHGNC:12538 UGT1A6

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167165

PTM / Processingi

Proteomic databases

EPDiB5MCT4
MaxQBiB5MCT4
PeptideAtlasiB5MCT4
PRIDEiB5MCT4

Expressioni

Gene expression databases

BgeeiENSG00000167165 Expressed in 56 organ(s), highest expression level in liver
ExpressionAtlasiB5MCT4 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 129UDPGTInterPro annotationAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili145 – 172Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOVERGENiHBG104751

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

B5MCT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNMVFIGGI NCKKRKDLSQ EFEAYINASG EHGIVVFSLG SMVSEIPEKK
60 70 80 90 100
AMAIADALGK IPQTVLWRYT GTRPSNLANN TILVKWLPQN DLLGHPMTRA
110 120 130 140 150
FITHAGSHGV YESICNGVPM VMMPLFGDQM DNAKRMETKG AGVTLNVLEM
160 170
TSEDLENALK AVINDKRKKQ QSGRQM
Length:176
Mass (Da):19,424
Last modified:October 14, 2008 - v1
Checksum:iAB6A151DE978D7D7
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P19224UD16_HUMAN
UDP-glucuronosyltransferase 1-6
UGT1A6 GNT1, UGT1
532Annotation score:
C9JMY5C9JMY5_HUMAN
UDP-glucuronosyltransferase 1-6
UGT1A6
189Annotation score:
H7C5F8H7C5F8_HUMAN
UDP-glucuronosyltransferase 1-6
UGT1A6
67Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006985 Genomic DNA No translation available.
AC114812 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000406651; ENSP00000386107; ENSG00000167165
ENST00000446481; ENSP00000401541; ENSG00000167165
UCSCiuc061tvn.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006985 Genomic DNA No translation available.
AC114812 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiB5MCT4
MaxQBiB5MCT4
PeptideAtlasiB5MCT4
PRIDEiB5MCT4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000406651; ENSP00000386107; ENSG00000167165
ENST00000446481; ENSP00000401541; ENSG00000167165
UCSCiuc061tvn.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000167165.18
HGNCiHGNC:12538 UGT1A6
OpenTargetsiENSG00000167165
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOVERGENiHBG104751

Gene expression databases

BgeeiENSG00000167165 Expressed in 56 organ(s), highest expression level in liver
ExpressionAtlasiB5MCT4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB5MCT4_HUMAN
AccessioniPrimary (citable) accession number: B5MCT4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: September 12, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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