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Protein
Submitted name:

Tripartite motif-containing protein 66

Gene

TRIM66

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Tripartite motif-containing protein 66Imported
Gene namesi
Name:TRIM66Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166436.15
HGNCiHGNC:29005 TRIM66

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166436

PTM / Processingi

Proteomic databases

EPDiB5MCJ9
PeptideAtlasiB5MCJ9
PRIDEiB5MCJ9

Expressioni

Gene expression databases

BgeeiENSG00000166436 Expressed in 179 organ(s), highest expression level in testis
ExpressionAtlasiB5MCJ9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliB5MCJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 46B box-typeInterPro annotationAdd BLAST46
Domaini60 – 101B box-typeInterPro annotationAdd BLAST42
Domaini999 – 1046PHD-typeInterPro annotationAdd BLAST48
Domaini1087 – 1159BromoInterPro annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili128 – 148Sequence analysisAdd BLAST21
Coiled coili157 – 184Sequence analysisAdd BLAST28

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG41106NJ LUCA
GeneTreeiENSGT00920000148978
HOGENOMiHOG000074104
HOVERGENiHBG057849
OMAiHLSCHLP
OrthoDBiEOG091G01KK
PhylomeDBiB5MCJ9
TreeFamiTF106455

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR003649 Bbox_C
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR037372 Trim66
IPR019786 Zinc_finger_PHD-type_CS
IPR000315 Znf_B-box
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
PANTHERiPTHR45154 PTHR45154, 1 hit
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF00628 PHD, 1 hit
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS50119 ZF_BBOX, 2 hits
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

B5MCJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARNCSECKE KRAAHILCTY CNRWLCSSCT EEHRHSPVPG GPFFPRAQKG
60 70 80 90 100
SPGVNGGPGD FTLYCPLHTQ EVLKLFCETC DMLTCHSCLV VEHKEHRHVE
110 120 130 140 150
EVLQNQRMLL EGVTTQVAHK KSSLQTSAKQ IEDRIFEVKH QHRKVENQIK
160 170 180 190 200
MAKMVLMNEL NKQANGLIEE LEGITNERKR KLEQQLQSIM VLNRQFEHVQ
210 220 230 240 250
NFINWAVCSK TSVPFLFSKE LIVFQMQRLL ETSCNTDPGS PWSIRFTWEP
260 270 280 290 300
NFWTKQLASL GCITTEGGQM SRADAPAYGG LQGSSPFYQS HQSPVAQQEA
310 320 330 340 350
LSHPSHKFQS PAVCSSSVCC SHCSPVSPSL KGQVPPPSIH PAHSFRQPPE
360 370 380 390 400
MVPQQLGSLQ CSALLPREKE LACSPHPPKL LQPWLETQPP VEQESTSQRL
410 420 430 440 450
GQQLTSQPVC IVPPQDVQQG AHAQPTLQTP SIQVQFGHHQ KLKLSHFQQQ
460 470 480 490 500
PQQQLPPPPP PLPHPPPPLP PPPQQPHPPL PPSQHLASSQ HESPPGPACS
510 520 530 540 550
QNMDIMHHKF ELEEMQKDLE LLLQAQQPSL QLSQTKSPQH LQQTIVGQIN
560 570 580 590 600
YIVRQPAPVQ SQSQEETLQA TDEPPASQGS KPALPLDKNT AAALPQASGE
610 620 630 640 650
ETPLSVPPVD STIQHSSPNV VRKHSTSLSI MGFSNTLEME LSSTRLERPL
660 670 680 690 700
EPQIQSVSNL TAGAPQAVPS LLSAPPKMVS SLTSVQNQAM PSLTTSHLQT
710 720 730 740 750
VPSLVHSTFQ SMPNLISDSP QAMASLASDH PQAGPSLMSG HTQAVPSLAT
760 770 780 790 800
CPLQSIPPVS DMQPETGSSS SSGRTSGSLC PRDGADPSLE NALCKMESED
810 820 830 840 850
STRFTDLLGQ GPIVPGLDAP KDLAIPSELE EPINLSVKKP PLAPVVSTST
860 870 880 890 900
ALQQYQNPKE CENFEQGALE LDAKENQSIR AFNSEHKIPY VRLERLKICA
910 920 930 940 950
ASSGEMPVFK LKPQKNDQDG SFLLIIECGT ESSSMSIKVS QDRLSEATQA
960 970 980 990 1000
PGLEGRKVTV TSLAGQRPPE VEGTSPEEHR LIPRTPGAKK GPPAPIENED
1010 1020 1030 1040 1050
FCAVCLNGGE LLCCDRCPKV FHLSCHVPAL LSFPGGEWVC TLCRSLTQPE
1060 1070 1080 1090 1100
MEYDCENACY NQPGMRASPG LSMYDQKKCE KLVLSLCCNN LSLPFHEPVS
1110 1120 1130 1140 1150
PLARHYYQII KRPMDLSIIR RKLQKKDPAH YTTPEEVVSD VRLMFWNCAK
1160 1170 1180 1190 1200
FNYPDSEVAE AGRCLEVFFE GWLKEIYPEK RFAQPRQEDS DSEEVSSESG
1210 1220 1230 1240
CSTPQGFPWP PYMQEGIQPK RRRRHMENER AKRMSFRLAN SISQV
Length:1,245
Mass (Da):137,658
Last modified:October 14, 2008 - v1
Checksum:i57A622485801A9DE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O15016TRI66_HUMAN
Tripartite motif-containing protein...
TRIM66 C11orf29, KIAA0298
1,216Annotation score:
A0A2R8YEA1A0A2R8YEA1_HUMAN
Tripartite motif-containing protein...
TRIM66
1,392Annotation score:
H0YF52H0YF52_HUMAN
Tripartite motif-containing protein...
TRIM66
286Annotation score:
A0A2R8YE93A0A2R8YE93_HUMAN
Tripartite motif-containing protein...
TRIM66
36Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091053 Genomic DNA No translation available.
AC104360 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000402157; ENSP00000384876; ENSG00000166436
UCSCiuc057ysc.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091053 Genomic DNA No translation available.
AC104360 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliB5MCJ9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiB5MCJ9
PeptideAtlasiB5MCJ9
PRIDEiB5MCJ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402157; ENSP00000384876; ENSG00000166436
UCSCiuc057ysc.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000166436.15
HGNCiHGNC:29005 TRIM66
OpenTargetsiENSG00000166436
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG41106NJ LUCA
GeneTreeiENSGT00920000148978
HOGENOMiHOG000074104
HOVERGENiHBG057849
OMAiHLSCHLP
OrthoDBiEOG091G01KK
PhylomeDBiB5MCJ9
TreeFamiTF106455

Miscellaneous databases

ChiTaRSiTRIM66 human

Gene expression databases

BgeeiENSG00000166436 Expressed in 179 organ(s), highest expression level in testis
ExpressionAtlasiB5MCJ9 baseline and differential

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR003649 Bbox_C
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR037372 Trim66
IPR019786 Zinc_finger_PHD-type_CS
IPR000315 Znf_B-box
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
PANTHERiPTHR45154 PTHR45154, 1 hit
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF00628 PHD, 1 hit
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS50119 ZF_BBOX, 2 hits
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB5MCJ9_HUMAN
AccessioniPrimary (citable) accession number: B5MCJ9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: October 10, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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