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UniProtKB - B5MC31 (B5MC31_HUMAN)
Protein
Submitted name:
E3 ubiquitin-protein ligase FANCL
Gene
FANCL
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin-protein transferase activity Source: InterPro
GO - Biological processi
- interstrand cross-link repair Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: E3 ubiquitin-protein ligase FANCLImported |
Gene namesi | Name:FANCLImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20748, FANCL |
VEuPathDBi | HostDB:ENSG00000115392 |
Subcellular locationi
Nucleus
- Fanconi anaemia nuclear complex Source: InterPro
- nuclear body Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000115392, Expressed in corpus callosum and 240 other tissues |
ExpressionAtlasi | B5MC31, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 92 | FANCL_d1InterPro annotationAdd BLAST | 86 | |
Domaini | 108 – 197 | FANCL_d2InterPro annotationAdd BLAST | 90 | |
Domaini | 200 – 230 | FANCL_d3InterPro annotationAdd BLAST | 31 | |
Domaini | 231 – 267 | FANCL_d3InterPro annotationAdd BLAST | 37 | |
Domaini | 276 – 343 | FANCL_CInterPro annotationAdd BLAST | 68 |
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000005537 |
Family and domain databases
Gene3Di | 3.10.110.10, 1 hit 3.10.110.20, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR026848, Fancl IPR026850, FANCL_C IPR043898, FANCL_d2 IPR044037, FANCL_d3 IPR043003, FANCL_d3_sf IPR019162, FancL_WD-rpt_cont_dom IPR016135, UBQ-conjugating_enzyme/RWD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR13206, PTHR13206, 2 hits |
Pfami | View protein in Pfam PF11793, FANCL_C, 1 hit PF09765, FANCL_d1, 1 hit PF18890, FANCL_d2, 1 hit PF18891, FANCL_d3, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
B5MC31-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVTEASLLR QCPLLLPQNR SKTVYEGFIS AQGRDFHLRI VLPEDLQLKN
60 70 80 90 100
ARLLCSWQLR TILSGYHRIV QQRMQHSPDL MSFMMELKML LEVALKNRQE
110 120 130 140 150
LYALPPPPQF YSSLIEEIGT LGWDKLVYAD TCFSTIKLKA EDASGREHLI
160 170 180 190 200
TLKLKAKYPA ESPDYFVDFP VPFCASWTPQ SSLISIYSQF LAAIESLKAF
210 220 230 240 250
WDVMDEIDEK TWVLEPEKPP RSATARRIAL VVKPLGIKLS RNIHLWDPEN
260 270 280 290 300
SVLQNLKDVL EIDFPARAIL EKSDFTMDCG ICYAYQLDGT IPDQVCDNSQ
310 320 330 340
CGQPFHQICL YEWLRGLLTS RQSFNIIFGE CPYCSKPITL KMSGRKH
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9NW38 | FANCL_HUMAN | E3 ubiquitin-protein ligase FANCL | FANCL PHF9 | 375 | Annotation score: | ||
C9JZA9 | C9JZA9_HUMAN | E3 ubiquitin-protein ligase FANCL | FANCL | 301 | Annotation score: | ||
H7C1M0 | H7C1M0_HUMAN | E3 ubiquitin-protein ligase FANCL | FANCL | 288 | Annotation score: | ||
B5MCZ6 | B5MCZ6_HUMAN | E3 ubiquitin-protein ligase FANCL | FANCL | 258 | Annotation score: | ||
C9J512 | C9J512_HUMAN | E3 ubiquitin-protein ligase FANCL | FANCL | 158 | Annotation score: | ||
C9JPN7 | C9JPN7_HUMAN | E3 ubiquitin-protein ligase FANCL | FANCL | 145 | Annotation score: | ||
A0A087X0C0 | A0A087X0C0_HUMAN | E3 ubiquitin-protein ligase FANCL | FANCL | 124 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007250 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000403295; ENSP00000386097; ENSG00000115392 |
UCSCi | uc010fce.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007250 Genomic DNA No translation available. |
3D structure databases
SMRi | B5MC31 |
ModBasei | Search... |
Proteomic databases
MaxQBi | B5MC31 |
PeptideAtlasi | B5MC31 |
ProteomicsDBi | 5980 |
Protocols and materials databases
Antibodypediai | 30496, 229 antibodies from 32 providers |
Genome annotation databases
Ensembli | ENST00000403295; ENSP00000386097; ENSG00000115392 |
UCSCi | uc010fce.4, human |
Organism-specific databases
HGNCi | HGNC:20748, FANCL |
OpenTargetsi | ENSG00000115392 |
VEuPathDBi | HostDB:ENSG00000115392 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000005537 |
Miscellaneous databases
ChiTaRSi | FANCL, human |
Gene expression databases
Bgeei | ENSG00000115392, Expressed in corpus callosum and 240 other tissues |
ExpressionAtlasi | B5MC31, baseline and differential |
Family and domain databases
Gene3Di | 3.10.110.10, 1 hit 3.10.110.20, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR026848, Fancl IPR026850, FANCL_C IPR043898, FANCL_d2 IPR044037, FANCL_d3 IPR043003, FANCL_d3_sf IPR019162, FancL_WD-rpt_cont_dom IPR016135, UBQ-conjugating_enzyme/RWD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR13206, PTHR13206, 2 hits |
Pfami | View protein in Pfam PF11793, FANCL_C, 1 hit PF09765, FANCL_d1, 1 hit PF18890, FANCL_d2, 1 hit PF18891, FANCL_d3, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | B5MC31_HUMAN | |
Accessioni | B5MC31Primary (citable) accession number: B5MC31 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 14, 2008 |
Last sequence update: | October 14, 2008 | |
Last modified: | January 19, 2022 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |