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UniProtKB - B5GLB3 (B5GLB3_STRCL)
Protein
Rhamnosyl O-methyltransferase
Gene
cmcI
Organism
Streptomyces clavuligerus
Status
Functioni
Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD).
ARBA annotationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 17 | S-adenosyl-L-methionine; via carbonyl oxygenCombined sources | 1 | |
Binding sitei | 95 | S-adenosyl-L-homocysteineCombined sources | 1 | |
Binding sitei | 95 | S-adenosyl-L-methionineCombined sources | 1 | |
Binding sitei | 121 | S-adenosyl-L-homocysteineCombined sources | 1 | |
Binding sitei | 121 | S-adenosyl-L-methionineCombined sources | 1 | |
Binding sitei | 161 | S-adenosyl-L-homocysteineCombined sources | 1 | |
Binding sitei | 187 | S-adenosyl-L-homocysteineCombined sources | 1 | |
Binding sitei | 187 | S-adenosyl-L-methionineCombined sources | 1 |
GO - Molecular functioni
- methyltransferase activity Source: InterPro
GO - Biological processi
- lipid biosynthetic process Source: InterPro
Keywordsi
Ligand | S-adenosyl-L-methionineCombined sources |
Names & Taxonomyi
Protein namesi | Recommended name: Rhamnosyl O-methyltransferaseARBA annotation |
Gene namesi | Name:cmcIImported ORF Names:SCLAV_4208Imported, SSCG_00137Imported |
Organismi | Streptomyces clavuligerusImported |
Taxonomic identifieri | 1901 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
Proteomesi |
|
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 64 – 65 | S-adenosyl-L-homocysteine bindingCombined sources | 2 | |
Regioni | 64 – 65 | S-adenosyl-L-methionine bindingCombined sources | 2 | |
Regioni | 87 – 91 | S-adenosyl-L-homocysteine bindingCombined sources | 5 | |
Regioni | 87 – 91 | S-adenosyl-L-methionine bindingCombined sources | 5 | |
Regioni | 116 – 117 | S-adenosyl-L-homocysteine bindingCombined sources | 2 | |
Regioni | 116 – 117 | S-adenosyl-L-methionine bindingCombined sources | 2 | |
Regioni | 138 – 139 | S-adenosyl-L-homocysteine bindingCombined sources | 2 | |
Regioni | 138 – 139 | S-adenosyl-L-methionine bindingCombined sources | 2 | |
Regioni | 160 – 161 | S-adenosyl-L-methionine bindingCombined sources | 2 |
Sequence similaritiesi
Belongs to the rhamnosyl O-methyltransferase family.ARBA annotation
Keywords - Domaini
SignalARBA annotationPhylogenomic databases
eggNOGi | COG3510, Bacteria |
OMAi | AHANTFN |
OrthoDBi | 1054856at2 |
Family and domain databases
Gene3Di | 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR007072, Rhamnosyl_O-MeTrfase_CmcI IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF04989, CmcI, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
i Sequence
Sequence statusi: Complete.
B5GLB3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNDYSRQNFL DLNLFRGLGE DPAYHPPVLT DRPRDWPLDR WAEAPRDLGY
60 70 80 90 100
SDFSPYQWRG LRMLKDPDTQ AVYHDMLWEL RPRTIVELGV YNGGSLAWFR
110 120 130 140 150
DLTKIMGIDC QVIGIDRDLS RCQIPASDME NITLHQGDCS DLTTFEHLRE
160 170 180 190 200
MAHPLIFIDD AHANTFNIMK WAVDHLLEEG DYFIIEDMIP YWYRYAPQLL
210 220 230
SEYLGAFRDV LSMDMLYANA SSQLDRGVLR RVAAKQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AH006362 Genomic DNA Translation: AAC32491.1 DS570624 Genomic DNA Translation: EDY47109.1 CM000913 Genomic DNA Translation: EFG09283.1 |
RefSeqi | WP_003952496.1, NZ_CP032052.1 |
Genome annotation databases
EnsemblBacteriai | EDY47109; EDY47109; SSCG_00137 |
GeneIDi | 61469711 |
KEGGi | sclf:BB341_07750 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AH006362 Genomic DNA Translation: AAC32491.1 DS570624 Genomic DNA Translation: EDY47109.1 CM000913 Genomic DNA Translation: EFG09283.1 |
RefSeqi | WP_003952496.1, NZ_CP032052.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2BM8 | X-ray | 2.50 | A/B/C/D/E/F/G/H/I/J/K/L | 1-236 | [»] | |
2BM9 | X-ray | 2.94 | A/B/C/D/E/F | 1-236 | [»] | |
2BR3 | X-ray | 2.79 | A/B/C/D/E/F | 1-236 | [»] | |
2BR4 | X-ray | 2.59 | A/B/C/D/E/F | 1-236 | [»] | |
2BR5 | X-ray | 2.83 | A/B/C/D/E/F | 1-236 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 1901.BB341_07750 |
Genome annotation databases
EnsemblBacteriai | EDY47109; EDY47109; SSCG_00137 |
GeneIDi | 61469711 |
KEGGi | sclf:BB341_07750 |
Phylogenomic databases
eggNOGi | COG3510, Bacteria |
OMAi | AHANTFN |
OrthoDBi | 1054856at2 |
Family and domain databases
Gene3Di | 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR007072, Rhamnosyl_O-MeTrfase_CmcI IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF04989, CmcI, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B5GLB3_STRCL | |
Accessioni | B5GLB3Primary (citable) accession number: B5GLB3 Secondary accession number(s): O85726 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 14, 2008 |
Last sequence update: | October 14, 2008 | |
Last modified: | May 25, 2022 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |