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Entry version 51 (07 Nov 2018)
Sequence version 2 (20 Jan 2016)
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Protein
Submitted name:

Uncharacterized protein, isoform E

Gene

Dpse\GA27025

Organism
Drosophila pseudoobscura pseudoobscura (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized protein, isoform EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dpse\GA27025Imported
ORF Names:Dpse_GA27025Imported, GA27025Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila pseudoobscura pseudoobscura (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri46245 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001819 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0248396 Dpse\GA27025

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0248396 Expressed in 5 organ(s), highest expression level in adult organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7237.FBpp0283375

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini288 – 311C2H2-typeInterPro annotationAdd BLAST24
Domaini542 – 570C2H2-typeInterPro annotationAdd BLAST29
Domaini733 – 761C2H2-typeInterPro annotationAdd BLAST29
Domaini764 – 792C2H2-typeInterPro annotationAdd BLAST29
Domaini868 – 895C2H2-typeInterPro annotationAdd BLAST28
Domaini1061 – 1084C2H2-typeInterPro annotationAdd BLAST24
Domaini1165 – 1187C2H2-typeInterPro annotationAdd BLAST23
Domaini1195 – 1218C2H2-typeInterPro annotationAdd BLAST24
Domaini1339 – 1361C2H2-typeInterPro annotationAdd BLAST23
Domaini1396 – 1423C2H2-typeInterPro annotationAdd BLAST28
Domaini1501 – 1529C2H2-typeInterPro annotationAdd BLAST29
Domaini1578 – 1605C2H2-typeInterPro annotationAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili335 – 355Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B5DMC5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012934 Znf_AD
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07776 zf-AD, 1 hit
PF00096 zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00868 zf-AD, 1 hit
SM00355 ZnF_C2H2, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

B5DMC5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCDTAATTAT PVVAATTVGA ASVSGTGTSQ GTAAATPATA GATPPATTAS
60 70 80 90 100
KPEQQRARQN CCRLCIAPAT ECISIINSYA ADKEPLSTKI HNCVDIKITP
110 120 130 140 150
QDRLSLQICH ACISYLNSWQ SFKNRSVSAQ SKQRQWLEAN KSKLLSYLDL
160 170 180 190 200
NSAENGGGHQ QHHHQNQQQH HSENEIDLEK PSAAQILDGI PSLKKRKSLT
210 220 230 240 250
VYPLPAIPIK DEPIDTDDDY QMKSLDESDD MVDPTMFLER SEHEGDVPLM
260 270 280 290 300
TSDYDYTAQH GVNAETAAAS LPPNAVANVA AAGDSKVASC RACSLQFSTR
310 320 330 340 350
ANARRHERNL HPNLFQLSTD SPNNTPITKP TPALAAALEI QRAAAEAATE
360 370 380 390 400
EASKAAGAAG GNISTQKYRQ VVMNAFIKCE GGGFNYDSPE QYQPLLTRDK
410 420 430 440 450
VEFIEQNYEF LEQYQTMTCR CCDKYFSTYK NFMAHVRKKY PLLPRNLCFN
460 470 480 490 500
CLKMNESKAL FISHLKKRNC INLFRVLNAL RGKQPNFHPS SDIGSSFGGE
510 520 530 540 550
TTTTTTTITS PNVVVPLLLD NSSSGERPEK LRAKELLVNK LYECKLCPKG
560 570 580 590 600
FRTKHEFRTH VYDKHADVQR KDNNSIQCSF CGLDFADPVD RRRHYNNMDC
610 620 630 640 650
IVRLRCMTCD AKVETHQRFL DHVYQDHLGG ISSDNASTVS GLGGGGGGGG
660 670 680 690 700
RSSSSIENSP GKRSLLGALG IGVGSPADES RTGSAAATAA AVAPNQTSTP
710 720 730 740 750
KPTSGGGAGT TPGSLNRDAG GAPKSQYFSR MPQVCPICGQ QYNNYNNVLR
760 770 780 790 800
HMESKHPNKL PETYKCVRCG LGYPRISYLR EHMINVHGVD KNRNSGGFEY
810 820 830 840 850
IVNADAVKLA DGSTPNVSTG RYDYVMKDLM SITNDDDEEE TGSMAKKIRL
860 870 880 890 900
DDSSNNSSLV GGVASQQKEC PICNALFSNN IGLSNHMRSH YTASSTVNAA
910 920 930 940 950
LVAANRMTPK SLTITAAPAI ETVTSSASVD VDDDEGVMPL ESGNIMASVS
960 970 980 990 1000
GGRGVASASA IAAVPPAMVN QTPQEQAVFR RSLDQAADRR FRRMRCRICQ
1010 1020 1030 1040 1050
RRFSSKKSYR YHMLTDHQVQ NVQFIKCKLC NAEFAYEKGL KVHLFKVHGR
1060 1070 1080 1090 1100
AIKDEMIVKQ FECDVCSIVY SSELELKQHK QSVHKLTSVS VSASASASAS
1110 1120 1130 1140 1150
ASASASTSSK IDDDSLMMED IGGNRSRHHH QQHSKASGDL ADQSIISAMA
1160 1170 1180 1190 1200
ATATASATTT PLYWYQCKYC PSNFNTNKKL AIHINSHDEF DSNDYSCKDC
1210 1220 1230 1240 1250
GNVYSGRKSL WVHRYKKHPQ VPDPIECMLC RKVFFDHQML DNHTPTCNRK
1260 1270 1280 1290 1300
PITATGAHQQ ELQTQSNQPQ GRAVFRHKTG DDDDEEEQQQ HNQQQQQRNH
1310 1320 1330 1340 1350
QEDAGDGGAV AAAAAAAAAA TSSGTISGVS TKKMRIPEVA CTICGARFTD
1360 1370 1380 1390 1400
QEHFSKHIQK HEQDLYVDNP LAAMFDDGPA DAAQFKVEGQ NENGEYACDM
1410 1420 1430 1440 1450
CTKTFPLVIA LKVHRKWHFR GDSKQNHIDS ETTNINNNNN NNSVNNSTSM
1460 1470 1480 1490 1500
LRELHAVGLT PNQQQKQQQQ NSTSTPNNNS SSNNNNSNSS KSRSMKRKRE
1510 1520 1530 1540 1550
LKCEYCPSTF ISNNNLRRHM YELHKHEVSS LPAPPVIVVD DPLCCRRCGN
1560 1570 1580 1590 1600
IKFETKELWI EHKLADAKVV RPFCPFQWGC DMCGEYLSRK EKLMNHINNH
1610 1620 1630 1640 1650
LKEDVIVPVA TQGAIDRERA STASSSSSSA SAASASASEA TTSKAKASSV
1660 1670 1680 1690 1700
LAEQPGATLQ KKTEENGGLD GAEAAVKADE DDSDMEDADS SDGDEESSGT
1710 1720 1730 1740 1750
GDEDDDDDDD DDDDDDDDDD DDEDEGEDEE GVPPPTPATQ LLPQQQEQQQ
1760 1770 1780 1790 1800
QHKHKANIDN DEDLVEEVIS SDDEEPEDGG EVESESQTES EEDDDEDDDE
1810 1820 1830 1840 1850
DDDDEEEEQA QEQEQASQPL VNGKSKEHQQ QIDEILPSSD DDEVGDGNLD
1860 1870 1880 1890 1900
GHLMAIDDII EEEFDEDDDM EEVDDGAVHP DPDDVIEEVD DDDADEVDEE
1910 1920 1930 1940 1950
HNVDGGGTSS ASSSESESTS TTTSNSHSTG ASPVSHQKPF PQWSKNLCLT
1960 1970
SNKQCNSNSN GNGNDDDCVE QL
Length:1,972
Mass (Da):215,771
Last modified:January 20, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CFFF4AEF3475B56
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R3NZU5A0A0R3NZU5_DROPS
Uncharacterized protein, isoform C
Dpse\GA27025 Dpse_GA27025, GA27025
2,038Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R3P539A0A0R3P539_DROPS
Uncharacterized protein, isoform B
Dpse\GA27025 Dpse_GA27025, GA27025
2,042Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R3P4P2A0A0R3P4P2_DROPS
Uncharacterized protein, isoform D
Dpse\GA27025 Dpse_GA27025, GA27025
1,976Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH379064 Genomic DNA Translation: EDY72643.2

NCBI Reference Sequences

More...
RefSeqi
XP_002134016.2, XM_002133980.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0377851; FBpp0338787; FBgn0248396

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6901315

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dpo:Dpse_GA27025

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH379064 Genomic DNA Translation: EDY72643.2
RefSeqiXP_002134016.2, XM_002133980.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7237.FBpp0283375

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0377851; FBpp0338787; FBgn0248396
GeneIDi6901315
KEGGidpo:Dpse_GA27025

Organism-specific databases

FlyBaseiFBgn0248396 Dpse\GA27025

Phylogenomic databases

InParanoidiB5DMC5

Gene expression databases

BgeeiFBgn0248396 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

InterProiView protein in InterPro
IPR012934 Znf_AD
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF07776 zf-AD, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00868 zf-AD, 1 hit
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB5DMC5_DROPS
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B5DMC5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: January 20, 2016
Last modified: November 7, 2018
This is version 51 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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