Fructose-bisphosphate aldolase A

Functionⁱ

Plays a key role in glycolysis and gluconeogenesis.By similarity

Miscellaneous

In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.Curated

Catalytic activityⁱ

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.By similarity

Pathwayⁱ: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.By similarity
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	43	SubstrateBy similarity	1
Active siteⁱ	188	Proton acceptorBy similarity	1
Active siteⁱ	230	Schiff-base intermediate with dihydroxyacetone-PBy similarity	1
Binding siteⁱ	304	SubstrateBy similarity	1
Siteⁱ	363	Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity	1

GO - Molecular functionⁱ

fructose-bisphosphate aldolase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

glycolytic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Lyase
Biological process	Glycolysis
Ligand	Schiff base

Enzyme and pathway databases

UniPathwayⁱ	UPA00109;UER00183

UniPathwayⁱ

UPA00109;UER00183

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fructose-bisphosphate aldolase A1 Publication (EC:4.1.2.13By similarity) Alternative name(s): Muscle-type aldolaseBy similarity Allergen: Sal s 3.01011 Publication
Organismⁱ	Salmo salar (Atlantic salmon)
Taxonomic identifierⁱ	8030 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Osteoglossocephalai › Clupeocephala › Euteleosteomorpha › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Salmo
Proteomesⁱ	UP000087266 Componentⁱ: Genome assembly

Pathology & Biotechⁱ

Allergenic propertiesⁱ

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseaseⁱ

Allergen

Protein family/group databases

Allergomeⁱ	10151 Sal s 3 10152 Sal s 3.0101

Allergomeⁱ

10151 Sal s 3
10152 Sal s 3.0101

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000425073	2 – 363	Fructose-bisphosphate aldolase AAdd BLAST		362

Proteomic databases

PRIDEⁱ	B5DGM7

PRIDEⁱ

B5DGM7

Interactionⁱ

Subunit structureⁱ

Tetramer.By similarity

Structureⁱ

3D structure databases

SMRⁱ	B5DGM7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the class I fructose-bisphosphate aldolase family.Sequence analysis

Phylogenomic databases

HOVERGENⁱ	HBG002386
KEGG Orthology (KO) More...KOⁱ	K01623

Family and domain databases

Gene3Dⁱ	3.20.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR029768 Aldolase_I_AS IPR013785 Aldolase_TIM IPR000741 FBA_I
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00274 Glycolytic, 1 hit
PROSITEⁱ	View protein in PROSITE PS00158 ALDOLASE_CLASS_I, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

B5DGM7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPHAFPFLTP DQKKELSDIA LKIVAKGKGI LAADESTGSV AKRFQSINTE 
        60         70         80         90        100
NTEENRRLYR QLLFTADDRA GPCIGGVIFF HETLYQKTDA GKTFPEHVKS 
       110        120        130        140        150
RGWVVGIKVD KGVVPLAGTN GETTTQGLDG LYERCAQYKK DGCDFAKWRC 
       160        170        180        190        200
VLKITSTTPS RLAIMENCNV LARYASICQM HGIVPIVEPE ILPDGDHDLK 
       210        220        230        240        250
RTQYVTEKVL AAMYKALSDH HVYLEGTLLK PNMVTAGHSC SHKYTHQEIA 
       260        270        280        290        300
MATVTALRRT VPPAVPGVTF LSGGQSEEEA SINLNVMNQC PLHRPWALTF 
       310        320        330        340        350
SYGRALQASA LKAWGGKPGN GKAAQEEFIK RALANSLACQ GKYVASGDSA 
       360 
AAGDSLFVAN HAY

Length:363

Mass (Da):39,556

Last modified:October 14, 2008 - v1

Checksum:ⁱ97FF0EA19E1D1C72

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT043786 mRNA Translation: ACH70901.1 BT043787 mRNA Translation: ACH70902.1 BT043788 mRNA Translation: ACH70903.1 BT043789 mRNA Translation: ACH70904.1 BT044037 mRNA Translation: ACH85353.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001133180.1, NM_001139708.1 NP_001133181.1, NM_001139709.1 XP_014014713.1, XM_014159238.1 XP_014014714.1, XM_014159239.1
UniGeneⁱ	Ssa.23672 Ssa.31354

Genome annotation databases

GeneIDⁱ	100194623 100194624
KEGGⁱ	sasa:100194623 sasa:100194624

Protein	Similar proteins		Species	Score	Length	Source
B5DGM7	Fructose-bisphosphate aldolase		SALSA		363	UniRef90_B5DGM7
Fructose-bisphosphate aldolase		ONCMY		396
Fructose-bisphosphate aldolase		ESOLU		363
UPI0009A04AC7		ONCKI		363
UPI000D09FF97		ONCTS		363
+8

Protein	Similar proteins		Species	Score	Length	Source
B5DGM7	Fructose-bisphosphate aldolase B		CHICK		364	UniRef50_P07341
Fructose-bisphosphate aldolase		AMAAE		395
Aldolase B fructose-bisphosphate (Fragment)		red-breasted parakeet		108
Fructose-bisphosphate aldolase B		TINGU		370
Fructose-bisphosphate aldolase		MELGA		365
+273

Entry informationⁱ

Entry nameⁱ	ALDOA_SALSA
Accessionⁱ	B5DGM7Primary (citable) accession number: B5DGM7 Secondary accession number(s): B5DGM8, B5DGM9, B5RIB3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 22, 2014
	Last sequence update:	October 14, 2008
	Last modified:	June 7, 2017
	This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB - B5DGM7 (ALDOA_SALSA)

Your basket is currently empty. ⁱ

Select a section on the left to see content.

Functionⁱ

Miscellaneous

Catalytic activityⁱ

Pathwayⁱ: glycolysis

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Allergenic propertiesⁱ

Keywords - Diseaseⁱ

Protein family/group databases

PTM / Processingⁱ

Molecule processing

Proteomic databases

Interactionⁱ

Subunit structureⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B5DGM7 (ALDOA_SALSA)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Fructose-bisphosphate aldolase A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Protein family/group databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ