UniProtKB - B5DGM7 (ALDOA_SALSA)
Protein
Fructose-bisphosphate aldolase A
Gene
N/A
Organism
Salmo salar (Atlantic salmon)
Status
Functioni
Plays a key role in glycolysis and gluconeogenesis.By similarity
Miscellaneous
In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.Curated
Catalytic activityi
- β-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphateBy similarityEC:4.1.2.13By similarity
: glycolysis Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.By similarityProteins known to be involved in the 4 steps of the subpathway in this organism are:
- Hexokinase (LOC106589825), Hexokinase (LOC106564733), Hexokinase (LOC106589825), Hexokinase (LOC106612430), Phosphotransferase (LOC106585167), Hexokinase (LOC106585103), Hexokinase (LOC106587516), Phosphotransferase (LOC106580495), Hexokinase (LOC106580495), Phosphotransferase (LOC106580581), Phosphotransferase (LOC106585167), Phosphotransferase (LOC106568009), Phosphotransferase (LOC106585167), Hexokinase (LOC106585103), Phosphotransferase (LOC106580581), Phosphotransferase (LOC106585167), Hexokinase (LOC106612435)
- Glucose-6-phosphate isomerase (LOC106587569), Glucose-6-phosphate isomerase (G6PI)
- ATP-dependent 6-phosphofructokinase, liver type-like (LOC106593347), ATP-dependent 6-phosphofructokinase (LOC106568830), ATP-dependent 6-phosphofructokinase (k6pp), ATP-dependent 6-phosphofructokinase, muscle type-like (LOC106572730), ATP-dependent 6-phosphofructokinase (LOC106568830), ATP-dependent 6-phosphofructokinase (k6pp), ATP-dependent 6-phosphofructokinase (LOC106578535), ATP-dependent 6-phosphofructokinase (LOC106582566), ATP-dependent 6-phosphofructokinase (LOC106583067), ATP-dependent 6-phosphofructokinase (K6PP), ATP-dependent 6-phosphofructokinase (LOC106565515), ATP-dependent 6-phosphofructokinase (LOC106578535), ATP-dependent 6-phosphofructokinase (k6pp), ATP-dependent 6-phosphofructokinase (LOC106578535), ATP-dependent 6-phosphofructokinase (LOC106572792), ATP-dependent 6-phosphofructokinase (LOC106566997), ATP-dependent 6-phosphofructokinase (LOC106578535), ATP-dependent 6-phosphofructokinase (LOC106578535), ATP-dependent 6-phosphofructokinase (LOC106578535), ATP-dependent 6-phosphofructokinase (LOC106578535)
- Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (LOC106612788), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase A, Fructose-bisphosphate aldolase (aldA), Fructose-bisphosphate aldolase (aldoc), Fructose-bisphosphate aldolase (LOC100194624), Fructose-bisphosphate aldolase (ALF1), Fructose-bisphosphate aldolase (ALDOC), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (LOC100194623), Fructose-bisphosphate aldolase (LOC106604855), Fructose-bisphosphate aldolase (ALDOA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 43 | SubstrateBy similarity | 1 | |
Active sitei | 188 | Proton acceptorBy similarity | 1 | |
Active sitei | 230 | Schiff-base intermediate with dihydroxyacetone-PBy similarity | 1 | |
Binding sitei | 304 | SubstrateBy similarity | 1 | |
Sitei | 363 | Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity | 1 |
GO - Molecular functioni
- fructose-bisphosphate aldolase activity Source: UniProtKB-EC
GO - Biological processi
- glycolytic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Lyase |
Biological process | Glycolysis |
Ligand | Schiff base |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00183 |
Names & Taxonomyi
Protein namesi | Recommended name: Fructose-bisphosphate aldolase A1 Publication (EC:4.1.2.13By similarity)Alternative name(s): Muscle-type aldolaseBy similarity Allergen: Sal s 3.01011 Publication |
Organismi | Salmo salar (Atlantic salmon) |
Taxonomic identifieri | 8030 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Salmo |
Proteomesi |
|
Pathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human. Binds to IgE.1 Publication
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 10151, Sal s 3 10152, Sal s 3.0101 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000425073 | 2 – 363 | Fructose-bisphosphate aldolase AAdd BLAST | 362 |
Interactioni
Subunit structurei
Tetramer.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the class I fructose-bisphosphate aldolase family.Sequence analysis
Phylogenomic databases
OrthoDBi | 799973at2759 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR029768, Aldolase_I_AS IPR013785, Aldolase_TIM IPR000741, FBA_I |
Pfami | View protein in Pfam PF00274, Glycolytic, 1 hit |
PROSITEi | View protein in PROSITE PS00158, ALDOLASE_CLASS_I, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B5DGM7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPHAFPFLTP DQKKELSDIA LKIVAKGKGI LAADESTGSV AKRFQSINTE
60 70 80 90 100
NTEENRRLYR QLLFTADDRA GPCIGGVIFF HETLYQKTDA GKTFPEHVKS
110 120 130 140 150
RGWVVGIKVD KGVVPLAGTN GETTTQGLDG LYERCAQYKK DGCDFAKWRC
160 170 180 190 200
VLKITSTTPS RLAIMENCNV LARYASICQM HGIVPIVEPE ILPDGDHDLK
210 220 230 240 250
RTQYVTEKVL AAMYKALSDH HVYLEGTLLK PNMVTAGHSC SHKYTHQEIA
260 270 280 290 300
MATVTALRRT VPPAVPGVTF LSGGQSEEEA SINLNVMNQC PLHRPWALTF
310 320 330 340 350
SYGRALQASA LKAWGGKPGN GKAAQEEFIK RALANSLACQ GKYVASGDSA
360
AAGDSLFVAN HAY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1S2WZE0 | A0A1S2WZE0_SALSA | Fructose-bisphosphate aldolase | LOC100194624 | 363 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT043786 mRNA Translation: ACH70901.1 BT043787 mRNA Translation: ACH70902.1 BT043788 mRNA Translation: ACH70903.1 BT043789 mRNA Translation: ACH70904.1 BT044037 mRNA Translation: ACH85353.1 |
RefSeqi | NP_001133180.1, NM_001139708.1 NP_001133181.1, NM_001139709.1 XP_014014713.1, XM_014159238.1 XP_014014714.1, XM_014159239.1 |
Genome annotation databases
Ensembli | ENSSSAT00000072663; ENSSSAP00000045746; ENSSSAG00000047233 |
GeneIDi | 100194623 100194624 |
KEGGi | sasa:100194623 sasa:100194624 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT043786 mRNA Translation: ACH70901.1 BT043787 mRNA Translation: ACH70902.1 BT043788 mRNA Translation: ACH70903.1 BT043789 mRNA Translation: ACH70904.1 BT044037 mRNA Translation: ACH85353.1 |
RefSeqi | NP_001133180.1, NM_001139708.1 NP_001133181.1, NM_001139709.1 XP_014014713.1, XM_014159238.1 XP_014014714.1, XM_014159239.1 |
3D structure databases
SMRi | B5DGM7 |
ModBasei | Search... |
Protein family/group databases
Allergomei | 10151, Sal s 3 10152, Sal s 3.0101 |
Genome annotation databases
Ensembli | ENSSSAT00000072663; ENSSSAP00000045746; ENSSSAG00000047233 |
GeneIDi | 100194623 100194624 |
KEGGi | sasa:100194623 sasa:100194624 |
Phylogenomic databases
OrthoDBi | 799973at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00183 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR029768, Aldolase_I_AS IPR013785, Aldolase_TIM IPR000741, FBA_I |
Pfami | View protein in Pfam PF00274, Glycolytic, 1 hit |
PROSITEi | View protein in PROSITE PS00158, ALDOLASE_CLASS_I, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ALDOA_SALSA | |
Accessioni | B5DGM7Primary (citable) accession number: B5DGM7 Secondary accession number(s): B5DGM8, B5DGM9, B5RIB3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 22, 2014 |
Last sequence update: | October 14, 2008 | |
Last modified: | December 2, 2020 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families