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UniProtKB - B5DFD6 (B5DFD6_RAT)
Protein
Receptor protein-tyrosine kinase
Gene
Tie1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Catalytic activityi
- EC:2.7.10.1ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 869 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- aortic valve morphogenesis Source: RGD
- blood vessel development Source: RGD
- branching involved in lymph vessel morphogenesis Source: RGD
- in utero embryonic development Source: RGD
- lymphatic endothelial cell differentiation Source: RGD
- negative regulation of angiogenesis Source: RGD
- negative regulation of cell migration Source: RGD
- plasma membrane fusion Source: RGD
- positive regulation of angiogenesis Source: GO_Central
- positive regulation of kinase activity Source: GO_Central
- regulation of endothelial cell proliferation Source: RGD
- regulation of extracellular matrix assembly Source: RGD
- response to retinoic acid Source: RGD
- tissue remodeling Source: RGD
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- vasculogenesis Source: RGD
Keywordsi
Molecular function | Kinase, ReceptorARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Tie1Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621642, Tie1 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: RGD
Other locations
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 760 – 785 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5014300049 | 22 – 1137 | Receptor protein-tyrosine kinaseSequence analysisAdd BLAST | 1116 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 247 ↔ 256 | PROSITE-ProRule annotation | ||
Disulfide bondi | 336 ↔ 345 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000020173, Expressed in lung and 21 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 226 – 257 | EGF-likeInterPro annotationAdd BLAST | 32 | |
Domaini | 312 – 346 | EGF-likeInterPro annotationAdd BLAST | 35 | |
Domaini | 352 – 443 | Ig-likeInterPro annotationAdd BLAST | 92 | |
Domaini | 447 – 544 | Fibronectin type-IIIInterPro annotationAdd BLAST | 98 | |
Domaini | 546 – 641 | Fibronectin type-IIIInterPro annotationAdd BLAST | 96 | |
Domaini | 645 – 738 | Fibronectin type-IIIInterPro annotationAdd BLAST | 94 | |
Domaini | 838 – 1117 | Protein kinaseInterPro annotationAdd BLAST | 280 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotation, Immunoglobulin domainARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000157693 |
HOGENOMi | CLU_008888_0_0_1 |
OMAi | AKVWWRL |
OrthoDBi | 707342at2759 |
TreeFami | TF317568 |
Family and domain databases
CDDi | cd00055, EGF_Lam, 1 hit cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR002049, LE_dom IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF00047, ig, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00181, EGF, 3 hits SM00060, FN3, 3 hits SM00409, IG, 2 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF49265, SSF49265, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 3 hits PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS50853, FN3, 3 hits PS50835, IG_LIKE, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
i Sequence
Sequence statusi: Complete.
B5DFD6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVWWGSPFLL PILFLASHVG ASVDLTLLAN LRITEPQRFF LTCVSGEAGA
60 70 80 90 100
GRSSDVWGPP LLLEKDDRIV RTFPPGQPLH LTRNGSHQVT LRGFSKPSDL
110 120 130 140 150
VGVFSCVGGA GTRRTRVLYV HNSPGAHLFP DKVTHTVNKG DTAVLSARVH
160 170 180 190 200
KEKQTDVIWK NNGSYFHTLD WHEAHDGRFQ LQLQNVQPPS SGIYSATYLE
210 220 230 240 250
ASPLGSAFFR LIVRGCEAGR WGPGCVKDCP GCLHGGVCHD HDGECVCPPG
260 270 280 290 300
FTGTRCEQAC REGRFGQSCQ EQCPGTAGCR GLTFCLPDPY GCSCGSGWRG
310 320 330 340 350
SQCQEACAPG HFGADCRLQC QCQNGGTCDR FSGCVCPSGW HGVHCEKSDR
360 370 380 390 400
IPQILNVATE LEFNLGTMPR INCAAAGNPF PVRGSMELRK PDGTMLLSTK
410 420 430 440 450
AIVEPDRTTA EFEVPRLTLG DSGFWECRVS TSGGQDSRRF KVNVKVPPVP
460 470 480 490 500
LTAPRLLAKQ SRQLVVSPLV SFGGDGPISS VRLHYRPQDS MITWSAIVVD
510 520 530 540 550
PSENVTLMNL KPRTGYNVRV QLSRPGEGGE GAWGPSTLMT TDCPEPLLQP
560 570 580 590 600
WVESWNVEGP DRLRVSWSLP SVPLSGDGFL LRLWDGARGQ ERRENISSPQ
610 620 630 640 650
ARTALLTGLT PGTHYQLDVR LYHCTLLGPA SPSAHVHLPL SGPPAPRHLR
660 670 680 690 700
AQALSDSEIR LMWQHPEAPP GPISKYIVEI QVAGGSGDPQ WMDVDKPEET
710 720 730 740 750
STTVRGLNAS TRYLFRVRAS VQGLGDWSNT VEETTLGNGL QSASPVQESR
760 770 780 790 800
VAEDGLDQQL VLAVVGSVSA TCLTILAALL ALVCIRRSCL HRRHTFTYQS
810 820 830 840 850
GSGEETILQF SSGTLTLTRR PKPQPEPLSY PVLEWEDITF EDLIGEGNFG
860 870 880 890 900
QVIRAMIKKD GLKMNAAIKM LKEYASENDH RDFAGELEVL CKLGHHPNII
910 920 930 940 950
NLLGACENRG YLYIAIEYAP YGNLLDFLRK SRVLETDPAF AREHGTASTL
960 970 980 990 1000
SSRQLLRFAS DAANGMQYLS EKQFIHRDLA ARNVLVGENL ASKIADFGLS
1010 1020 1030 1040 1050
RGEEVYVKKT MGRLPVRWMA IESLNYSVYT TKSDVWSFGV LLWEIVSLGG
1060 1070 1080 1090 1100
TPYCGMTCAE LYEKLPQGYR MEQPRNCDDE VYELMRQCWR DRPYERPPFA
1110 1120 1130
QIALQLGRML EARKAYVNMS LFENFTYAGI DATAEEA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC169020 mRNA Translation: AAI69020.1 |
RefSeqi | NP_445997.1, NM_053545.1 |
Genome annotation databases
Ensembli | ENSRNOT00000027414.8; ENSRNOP00000027414.5; ENSRNOG00000020173.8 |
GeneIDi | 89806 |
KEGGi | rno:89806 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC169020 mRNA Translation: AAI69020.1 |
RefSeqi | NP_445997.1, NM_053545.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027414 |
Genome annotation databases
Ensembli | ENSRNOT00000027414.8; ENSRNOP00000027414.5; ENSRNOG00000020173.8 |
GeneIDi | 89806 |
KEGGi | rno:89806 |
Organism-specific databases
CTDi | 7075 |
RGDi | 621642, Tie1 |
Phylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000157693 |
HOGENOMi | CLU_008888_0_0_1 |
OMAi | AKVWWRL |
OrthoDBi | 707342at2759 |
TreeFami | TF317568 |
Gene expression databases
Bgeei | ENSRNOG00000020173, Expressed in lung and 21 other tissues |
Family and domain databases
CDDi | cd00055, EGF_Lam, 1 hit cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013151, Immunoglobulin IPR011009, Kinase-like_dom_sf IPR002049, LE_dom IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF00047, ig, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00181, EGF, 3 hits SM00060, FN3, 3 hits SM00409, IG, 2 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF49265, SSF49265, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 3 hits PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS50853, FN3, 3 hits PS50835, IG_LIKE, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B5DFD6_RAT | |
Accessioni | B5DFD6Primary (citable) accession number: B5DFD6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 14, 2008 |
Last sequence update: | October 14, 2008 | |
Last modified: | May 25, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |