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Entry version 82 (16 Jan 2019)
Sequence version 1 (14 Oct 2008)
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Protein

Nidogen-2

Gene

Nid2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion glycoprotein. Might be involved in osteoblast differentiation. It probably has a role in cell-extracellular matrix interactions (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nidogen-2
Short name:
NID-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nid2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
1311685 Nid2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30By similarityAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000039206431 – 1396Nidogen-2Add BLAST1366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi504 ↔ 517By similarity
Disulfide bondi511 ↔ 526By similarity
Disulfide bondi528 ↔ 539By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi674N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi719N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi779 ↔ 792By similarity
Disulfide bondi786 ↔ 802By similarity
Disulfide bondi804 ↔ 815By similarity
Disulfide bondi821 ↔ 834By similarity
Disulfide bondi828 ↔ 843By similarity
Disulfide bondi845 ↔ 858By similarity
Disulfide bondi868 ↔ 883By similarity
Disulfide bondi875 ↔ 893By similarity
Disulfide bondi895 ↔ 906By similarity
Disulfide bondi912 ↔ 923By similarity
Disulfide bondi917 ↔ 932By similarity
Disulfide bondi961 ↔ 984By similarity
Disulfide bondi995 ↔ 1002By similarity
Disulfide bondi1004 ↔ 1026By similarity
Disulfide bondi1040 ↔ 1064By similarity
Disulfide bondi1075 ↔ 1082By similarity
Disulfide bondi1084 ↔ 1105By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1329Omega-N-methylarginineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B5DFC9

PeptideAtlas

More...
PeptideAtlasi
B5DFC9

PRoteomics IDEntifications database

More...
PRIDEi
B5DFC9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B5DFC9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B5DFC9

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
B5DFC9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LAMA2. Interacts with COL13A1 (By similarity).By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000000383

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B5DFC9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 274NIDOPROSITE-ProRule annotationAdd BLAST167
Domaini500 – 540EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini544 – 774Nidogen G2 beta-barrelPROSITE-ProRule annotationAdd BLAST231
Domaini775 – 816EGF-like 2PROSITE-ProRule annotationAdd BLAST42
Domaini817 – 859EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini864 – 907EGF-like 4PROSITE-ProRule annotationAdd BLAST44
Domaini908 – 944EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini958 – 1026Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST69
Domaini1037 – 1105Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST69
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1175 – 1218LDL-receptor class B 1Add BLAST44
Repeati1219 – 1261LDL-receptor class B 2Add BLAST43
Repeati1262 – 1306LDL-receptor class B 3Add BLAST45
Repeati1307 – 1348LDL-receptor class B 4Add BLAST42

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMYX Eukaryota
ENOG4111DVZ LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000072712

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG056551

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B5DFC9

KEGG Orthology (KO)

More...
KOi
K06826

Database of Orthologous Groups

More...
OrthoDBi
95286at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B5DFC9

TreeFam database of animal gene trees

More...
TreeFami
TF320666

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00255 nidG2, 1 hit
cd00191 TY, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 1 hit
4.10.800.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR006605 G2_nidogen/fibulin_G2F
IPR009017 GFP
IPR009030 Growth_fac_rcpt_cys_sf
IPR000033 LDLR_classB_rpt
IPR003886 NIDO_dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645 EGF_CA, 2 hits
PF07474 G2F, 1 hit
PF00058 Ldl_recept_b, 2 hits
PF06119 NIDO, 1 hit
PF00086 Thyroglobulin_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 4 hits
SM00682 G2F, 1 hit
SM00135 LY, 4 hits
SM00539 NIDO, 1 hit
SM00211 TY, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54511 SSF54511, 1 hit
SSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 2 hits
PS51120 LDLRB, 4 hits
PS51220 NIDO, 1 hit
PS50993 NIDOGEN_G2, 1 hit
PS00484 THYROGLOBULIN_1_1, 2 hits
PS51162 THYROGLOBULIN_1_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: B5DFC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWDPTAGRL APPSPLSLLL VLVLLSRVGA LRPEELFPYG ESWGDRLLPE
60 70 80 90 100
GDDESSAAVK LAVPLRFYDA QFSNLYVGTN GIISTQDFPR ETQYVDDDFP
110 120 130 140 150
TDFPAIAPFL ADIDTSHSRG RILYREDTSQ AVLSLAARYV RTGFPLTGSS
160 170 180 190 200
FTPTHAFLAT WEHVGAYEEV RRGAAPSGEL NTFQAVLASD ESDTYALFLY
210 220 230 240 250
PANGLQFFGT RPKESYNVQL QLPARVGFCR GEADDLKREA LYFSLTNTEQ
260 270 280 290 300
SVKNLYQLSN LGIPGAWAFH IGSRLALDNV RPATVGGDHS TARSSALEHS
310 320 330 340 350
FNHAAALESY TEDSFDYYNE NEEDVEYPPI EPGEALEGHS RIDVSFNSEV
360 370 380 390 400
NPTSPDSDHA SPLPHPAPGN WPSYRETESA SLDPQTKQGP PVGEVEVLDF
410 420 430 440 450
KDPAELLDQT GTRTPAPPGA DAAFLTPGRE DLGNRDTQSY PEARPVPSEP
460 470 480 490 500
DVPVAPLERE ILPNYPESGH VPPLSGGRYV VGLEDHVSSK DQVFTYNGAN
510 520 530 540 550
RETCEHSHGQ CSRHAFCTDY TTGFCCHCQS RFYGNGRHCV PEGAPHRVNG
560 570 580 590 600
KVSGHLQVGH MPVHFTDVDL HAYIVSNDGR AYTAISQIPQ PAAQALLPVL
610 620 630 640 650
PIGGLFGWLF ALEKPGSENG FSLTGATFVH DVEVTFHPGE ERVRITQTAE
660 670 680 690 700
GLDPENYLSL NTNIEGQVPF IPANFTAHIA PYQEFYHHRD SVVTSSSSRS
710 720 730 740 750
FSLISGSINQ TRSYRIDQNI TYKACSHAPR HLAVPATQQL TVDRAFALYS
760 770 780 790 800
EEEGVLRFAV TNQIGPVEVD SAPTAVNPCY DGSHTCDTTA RCHPGTGVDY
810 820 830 840 850
TCECTPGFQG DGRSCVDVNE CATGFHRCGP NSVCVNLVGS YRCECRSGYE
860 870 880 890 900
FADDRHTCVL IAPPPNPCLD GSHTCAPEGQ ARCIHHGGSS FSCACLPGFV
910 920 930 940 950
GTGHQCSDVD ECAENRCHGA AICYNTPGSF SCRCQPGYHG DGFHCASDTV
960 970 980 990 1000
PEDSISGLKP CEYQQRYAQA QHAHAGSRIH IPQCDDQGNF VPLQCHGSTG
1010 1020 1030 1040 1050
FCWCVDQNGH EVPGTQTPPG STPPHCGPPP EPTQRPRTVC ERWRESLLEH
1060 1070 1080 1090 1100
YGGTPRDDQY VPQCDDLGHF IPLQCHGKSD FCWCVDKDGR ELPGTRSQPG
1110 1120 1130 1140 1150
TMPACIPTVA PPVVRPTPRP DVTPPAVGTF LLYAQGQQIG HLPLNGSRLQ
1160 1170 1180 1190 1200
KDAARTLLSL HGSIVVGIDY DCRERMVYWT DVAGRTISRA SLEAGAEPET
1210 1220 1230 1240 1250
IITSGLISPE GLAIDHFRRT MYWTDSGLDK IERAGLDGSE RKVLFHTDLV
1260 1270 1280 1290 1300
NPRAITVDPI RGNLYWTDWN REAPKIETSS LDGENRRILI NKDIGLPNGL
1310 1320 1330 1340 1350
TFDPFSKLLC WADAGTKKLE CTLPDGTGRR VIQNHLNYPF SVVSYADHFY
1360 1370 1380 1390
HTDWRRDGVI SVSKDSGQLT DEYLPEQRSH LYGITAVYPY CPTGRK
Length:1,396
Mass (Da):152,976
Last modified:October 14, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0C9D1C6943240D7
GO
Isoform 2 (identifier: B5DFC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1220: Missing.

Note: No experimental confirmation available.
Show »
Length:176
Mass (Da):20,123
Checksum:iE9E820D47169E3D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
W4VSR4W4VSR4_RAT
Nidogen-2
Nid2
1,438Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K3C8A0A0G2K3C8_RAT
Nidogen-2
Nid2
1,395Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0387811 – 1220Missing in isoform 2. 1 PublicationAdd BLAST1220

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH474061 Genomic DNA Translation: EDL86201.1
BC088325 mRNA Translation: AAH88325.1
BC169012 mRNA Translation: AAI69012.1

NCBI Reference Sequences

More...
RefSeqi
NP_001012005.2, NM_001012005.2 [B5DFC9-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.98892

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
302248

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:302248

UCSC genome browser

More...
UCSCi
RGD:1311685 rat [B5DFC9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474061 Genomic DNA Translation: EDL86201.1
BC088325 mRNA Translation: AAH88325.1
BC169012 mRNA Translation: AAI69012.1
RefSeqiNP_001012005.2, NM_001012005.2 [B5DFC9-1]
UniGeneiRn.98892

3D structure databases

SMRiB5DFC9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000383

PTM databases

iPTMnetiB5DFC9
PhosphoSitePlusiB5DFC9
UniCarbKBiB5DFC9

Proteomic databases

PaxDbiB5DFC9
PeptideAtlasiB5DFC9
PRIDEiB5DFC9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi302248
KEGGirno:302248
UCSCiRGD:1311685 rat [B5DFC9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22795
RGDi1311685 Nid2

Phylogenomic databases

eggNOGiENOG410IMYX Eukaryota
ENOG4111DVZ LUCA
HOGENOMiHOG000072712
HOVERGENiHBG056551
InParanoidiB5DFC9
KOiK06826
OrthoDBi95286at2759
PhylomeDBiB5DFC9
TreeFamiTF320666

Miscellaneous databases

Protein Ontology

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PROi
PR:B5DFC9

Family and domain databases

CDDicd00255 nidG2, 1 hit
cd00191 TY, 2 hits
Gene3Di2.120.10.30, 1 hit
4.10.800.10, 2 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR006605 G2_nidogen/fibulin_G2F
IPR009017 GFP
IPR009030 Growth_fac_rcpt_cys_sf
IPR000033 LDLR_classB_rpt
IPR003886 NIDO_dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07645 EGF_CA, 2 hits
PF07474 G2F, 1 hit
PF00058 Ldl_recept_b, 2 hits
PF06119 NIDO, 1 hit
PF00086 Thyroglobulin_1, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 4 hits
SM00682 G2F, 1 hit
SM00135 LY, 4 hits
SM00539 NIDO, 1 hit
SM00211 TY, 2 hits
SUPFAMiSSF54511 SSF54511, 1 hit
SSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 2 hits
PS51120 LDLRB, 4 hits
PS51220 NIDO, 1 hit
PS50993 NIDOGEN_G2, 1 hit
PS00484 THYROGLOBULIN_1_1, 2 hits
PS51162 THYROGLOBULIN_1_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNID2_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B5DFC9
Secondary accession number(s): Q5M812
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: October 14, 2008
Last modified: January 16, 2019
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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