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Protein

Mitochondrial ribonuclease P catalytic subunit

Gene

Mrpp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends.By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 Mg2+ or Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi348ZincBy similarity1
Metal bindingi351ZincBy similarity1
Metal bindingi409Magnesium or manganese 1; catalyticBy similarity1
Metal bindingi478Magnesium or manganese 1; catalyticBy similarity1
Metal bindingi479Magnesium or manganese 2; catalyticBy similarity1
Metal bindingi499Magnesium or manganese 2; catalyticBy similarity1
Metal bindingi557Zinc; via tele nitrogenBy similarity1
Metal bindingi578ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nuclease
Biological processtRNA processing
LigandMagnesium, Manganese, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ribonuclease P catalytic subunitBy similarity (EC:3.1.26.5By similarity)
Alternative name(s):
Mitochondrial ribonuclease P protein 3By similarity
Short name:
Mitochondrial RNase P protein 3By similarity
Gene namesi
Name:Mrpp3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1305089 RGD1305089

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionSequence analysisAdd BLAST46
ChainiPRO_000036039847 – 587Mitochondrial ribonuclease P catalytic subunitAdd BLAST541

Post-translational modificationi

Degraded by LONP1 following mitochondrial unfolded protein response, probably leading to inhibit translation in mitochondrion.By similarity

Proteomic databases

PaxDbiB5DF07
PeptideAtlasiB5DF07
PRIDEiB5DF07

Expressioni

Gene expression databases

BgeeiENSRNOG00000007043 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiB5DF07 RN

Interactioni

Subunit structurei

Catalytic component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP31.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009306

Structurei

3D structure databases

SMRiB5DF07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini342 – 578PRORPAdd BLAST237

Domaini

Displays a distorted and non-productive active site that probably switches to a fully productive state only upon association with TRMT10C/MRPP1, HSD17B10/MRPP2 and pre-tRNA substrate.By similarity

Sequence similaritiesi

Belongs to the PPR family. P subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IE4T Eukaryota
ENOG4111GT9 LUCA
GeneTreeiENSGT00390000002201
HOGENOMiHOG000294131
HOVERGENiHBG099441
InParanoidiB5DF07
KOiK17655
OMAiHDDPFLL
OrthoDBiEOG091G0JTR
PhylomeDBiB5DF07
TreeFamiTF324726

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR033495 MRPP3
IPR031595 PRORP_C
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR13547:SF1 PTHR13547:SF1, 1 hit
PfamiView protein in Pfam
PF16953 PRORP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5DF07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFYLSGFRS FLKLWKSNPY FELGPATSSA SFFLGVHCVI GNQQRWFSVK
60 70 80 90 100
PTTPPNSKIL NLLVTKARTL KKGNDSNKQA SSGPHYFAAG EAKKRSHLSG
110 120 130 140 150
NPQNQGHTLP VKSTVQLPTK PLNSEEWDKL KEDFKGKASF EDFVISQMTR
160 170 180 190 200
SCSSVDVAKS LLAWVAAKNN GIVGYNLLVK YLYLCVFHKQ TSEVIDVYEI
210 220 230 240 250
MKAKYKSLES GGYTLLIRGL IHSDRWREAL LLLEDIKKVM VPSKKNYGDC
260 270 280 290 300
IQGALLHQDV NVAWSLYQEL VGHNLIPLLE TLKAFFDHGK DMNDDQYSNQ
310 320 330 340 350
LLDILLYLRN NQLYPGESFA HSIKTWFESI PGRQWKGQFT TIQKSGQCSS
360 370 380 390 400
CGRAIESIHL SPEEYEFLKE TIMRDVIDGG DQYKKTTPQE LKRFERFVKS
410 420 430 440 450
CPPFDIVIDG LNVAKMFPKG RESQNLLGIV SQLAQQNLQL LVLGRKHMLR
460 470 480 490 500
PSSQWRKDEM EQVRKQAHCF FADNISEDDP FLLYATLNSG SHCKFITKDL
510 520 530 540 550
LRDHKACLPD ARAQRLFFKW QQGHQLAITK GFLKSKLTFQ HILSYDTVVQ
560 570 580
TTGDTWHIPY DEDLVPRSSC EVPTKWLCLQ RKTPAPC
Length:587
Mass (Da):67,008
Last modified:October 14, 2008 - v1
Checksum:iF065F7875751BC08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473947 Genomic DNA Translation: EDM03424.1
BC168878 mRNA Translation: AAI68878.1
RefSeqiNP_001100200.1, NM_001106730.2
UniGeneiRn.35652

Genome annotation databases

EnsembliENSRNOT00000009304; ENSRNOP00000009306; ENSRNOG00000007043
GeneIDi299050
KEGGirno:299050
UCSCiRGD:1305089 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473947 Genomic DNA Translation: EDM03424.1
BC168878 mRNA Translation: AAI68878.1
RefSeqiNP_001100200.1, NM_001106730.2
UniGeneiRn.35652

3D structure databases

SMRiB5DF07
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009306

Proteomic databases

PaxDbiB5DF07
PeptideAtlasiB5DF07
PRIDEiB5DF07

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009304; ENSRNOP00000009306; ENSRNOG00000007043
GeneIDi299050
KEGGirno:299050
UCSCiRGD:1305089 rat

Organism-specific databases

CTDi299050
RGDi1305089 RGD1305089

Phylogenomic databases

eggNOGiENOG410IE4T Eukaryota
ENOG4111GT9 LUCA
GeneTreeiENSGT00390000002201
HOGENOMiHOG000294131
HOVERGENiHBG099441
InParanoidiB5DF07
KOiK17655
OMAiHDDPFLL
OrthoDBiEOG091G0JTR
PhylomeDBiB5DF07
TreeFamiTF324726

Miscellaneous databases

PROiPR:B5DF07

Gene expression databases

BgeeiENSRNOG00000007043 Expressed in 10 organ(s), highest expression level in testis
GenevisibleiB5DF07 RN

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR033495 MRPP3
IPR031595 PRORP_C
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR13547:SF1 PTHR13547:SF1, 1 hit
PfamiView protein in Pfam
PF16953 PRORP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMRPP3_RAT
AccessioniPrimary (citable) accession number: B5DF07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: October 14, 2008
Last modified: September 12, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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