Embryonic ectoderm development

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Epigenetic control of female puberty."
    Lomniczi A., Loche A., Castellano J.M., Ronnekleiv O.K., Bosch M., Kaidar G., Knoll J.G., Wright H., Pfeifer G.P., Ojeda S.R.
    Nat. Neurosci. 16:281-289(2013) [PubMed] [Europe PMC] [Abstract]
• histone methyltransferase activity Source: RGDInferred from sequence orthologyⁱ
  • "Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity."
    Pasini D., Bracken A.P., Jensen M.R., Lazzerini Denchi E., Helin K.
    EMBO J. 23:4061-4071(2004) [PubMed] [Europe PMC] [Abstract]
• histone methyltransferase activity (H3-K27 specific) Source: Ensembl
• identical protein binding Source: RGDInferred from sequence orthologyⁱ
  • "The Drosophila polycomb group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3."
    Tie F., Furuyama T., Prasad-Sinha J., Jane E., Harte P.J.
    Development 128:275-286(2001) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Juxtaposed Polycomb complexes co-regulate vertebral identity."
    Kim S.Y., Paylor S.W., Magnuson T., Schumacher A.
    Development 133:4957-4968(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to leukemia inhibitory factor Source: RGDInferred from sequence orthologyⁱ
  • "miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells."
    Tarantino C., Paolella G., Cozzuto L., Minopoli G., Pastore L., Parisi S., Russo T.
    FASEB J. 24:3255-3263(2010) [PubMed] [Europe PMC] [Abstract]
• chromatin silencing Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• histone methylation Source: RGDInferred from sequence orthologyⁱ
  • "The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation."
    Montgomery N.D., Yee D., Chen A., Kalantry S., Chamberlain S.J., Otte A.P., Magnuson T.
    Curr. Biol. 15:942-947(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: RGDInferred from direct assayⁱ
  • "Epigenetic control of female puberty."
    Lomniczi A., Loche A., Castellano J.M., Ronnekleiv O.K., Bosch M., Kaidar G., Knoll J.G., Wright H., Pfeifer G.P., Ojeda S.R.
    Nat. Neurosci. 16:281-289(2013) [PubMed] [Europe PMC] [Abstract]
• oligodendrocyte differentiation Source: Ensembl
• positive regulation of histone H3-K27 methylation Source: RGDInferred from sequence orthologyⁱ
  • "Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation."
    Montgomery N.D., Yee D., Montgomery S.A., Magnuson T.
    J. Mol. Biol. 374:1145-1157(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of adaxial/abaxial pattern formation Source: RGDInferred from sequence orthologyⁱ
  • "Juxtaposed Polycomb complexes co-regulate vertebral identity."
    Kim S.Y., Paylor S.W., Magnuson T., Schumacher A.
    Development 133:4957-4968(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression by genetic imprinting Source: RGDInferred from sequence orthologyⁱ
  • "Genome imprinting regulated by the mouse Polycomb group protein Eed."
    Mager J., Montgomery N.D., de Villena F.P.-M., Magnuson T.
    Nat. Genet. 33:502-507(2003) [PubMed] [Europe PMC] [Abstract]
• spinal cord development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Polycomb group proteins are essential for spinal cord development."
    Wang C., Zhao J.J., Lu C.L., Han X.D., An L.S., Ma X.
    Front Biosci (Landmark Ed) 15:1018-1022(2010) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• identical protein binding Source: RGDInferred from sequence orthologyⁱ
  • "The Drosophila polycomb group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3."
    Tie F., Furuyama T., Prasad-Sinha J., Jane E., Harte P.J.
    Development 128:275-286(2001) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT 
        60         70         80         90        100
ERPDTPTNTP NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ 
       110        120        130        140        150
FNWHSKEGDP LVFATVGSNR VTLYECHSQG EIRLLQSYVD ADADENFYTC 
       160        170        180        190        200
AWTYDSNTSH PLLAVAGSRG IIRIINPITM QCIKHYVGHG NAINELKFHP 
       210        220        230        240        250
RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL SADYDLLGEK 
       260        270        280        290        300
IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS 
       310        320        330        340        350
TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV 
       360        370        380        390        400
TILGRFDYSQ CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK 
       410        420        430        440 
CTTLTHHKCG AAIRQTSFSR DSSILIAVCD DASIWRWDRL R          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ