UniProtKB - B5DF02 (B5DF02_RAT)
Protein
Submitted name:
Embryonic ectoderm development
Gene
Eed
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: RGD
- histone methyltransferase activity Source: RGD
- identical protein binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: RGD
- chromatin silencing Source: GO_Central
- histone H3-K27 methylation Source: GOC
- histone methylation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- oligodendrocyte differentiation Source: Ensembl
- positive regulation of histone H3-K27 methylation Source: RGD
- regulation of adaxial/abaxial pattern formation Source: RGD
- regulation of gene expression by genetic imprinting Source: RGD
- spinal cord development Source: RGD
Enzyme and pathway databases
Reactomei | R-RNO-212300, PRC2 methylates histones and DNA R-RNO-2559580, Oxidative Stress Induced Senescence R-RNO-3214841, PKMTs methylate histone lysines R-RNO-8943724, Regulation of PTEN gene transcription R-RNO-8953750, Transcriptional Regulation by E2F6 |
Names & Taxonomyi
Protein namesi | Submitted name: Embryonic ectoderm developmentImportedSubmitted name: Embryonic ectoderm development (Predicted)Imported |
Gene namesi | ORF Names:rCG_40676Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309782, Eed |
Subcellular locationi
Nucleus
- chromatin silencing complex Source: Ensembl
- ESC/E(Z) complex Source: RGD
- nucleus Source: RGD
- pronucleus Source: RGD
- sex chromatin Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000017509, Expressed in thymus and 21 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000024082 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 186 – 273 | WD_REPEATS_REGIONInterPro annotationAdd BLAST | 88 | |
Repeati | 186 – 228 | WDPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 232 – 273 | WDPROSITE-ProRule annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 72 | DisorderedSequence analysisAdd BLAST | 72 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 41 – 64 | PolarSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the WD repeat ESC family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1034, Eukaryota |
GeneTreei | ENSGT00510000047334 |
HOGENOMi | CLU_032683_1_0_1 |
OMAi | SCENCIV |
OrthoDBi | 1191277at2759 |
TreeFami | TF314451 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR037352, Polycomb_EED IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10253:SF5, PTHR10253:SF5, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
B5DF02-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT
60 70 80 90 100
ERPDTPTNTP NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ
110 120 130 140 150
FNWHSKEGDP LVFATVGSNR VTLYECHSQG EIRLLQSYVD ADADENFYTC
160 170 180 190 200
AWTYDSNTSH PLLAVAGSRG IIRIINPITM QCIKHYVGHG NAINELKFHP
210 220 230 240 250
RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL SADYDLLGEK
260 270 280 290 300
IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS
310 320 330 340 350
TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV
360 370 380 390 400
TILGRFDYSQ CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK
410 420 430 440
CTTLTHHKCG AAIRQTSFSR DSSILIAVCD DASIWRWDRL R
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07004747 Genomic DNA No translation available. AABR07004748 Genomic DNA No translation available. BC168872 mRNA Translation: AAI68872.1 CH473956 Genomic DNA Translation: EDM18565.1 |
RefSeqi | NP_001099748.1, NM_001106278.2 |
Genome annotation databases
Ensembli | ENSRNOT00000024082; ENSRNOP00000024082; ENSRNOG00000017509 |
GeneIDi | 293104 |
KEGGi | rno:293104 |
UCSCi | RGD:1309782, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07004747 Genomic DNA No translation available. AABR07004748 Genomic DNA No translation available. BC168872 mRNA Translation: AAI68872.1 CH473956 Genomic DNA Translation: EDM18565.1 |
RefSeqi | NP_001099748.1, NM_001106278.2 |
3D structure databases
SMRi | B5DF02 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000024082 |
Proteomic databases
PRIDEi | B5DF02 |
Genome annotation databases
Ensembli | ENSRNOT00000024082; ENSRNOP00000024082; ENSRNOG00000017509 |
GeneIDi | 293104 |
KEGGi | rno:293104 |
UCSCi | RGD:1309782, rat |
Organism-specific databases
CTDi | 8726 |
RGDi | 1309782, Eed |
Phylogenomic databases
eggNOGi | KOG1034, Eukaryota |
GeneTreei | ENSGT00510000047334 |
HOGENOMi | CLU_032683_1_0_1 |
OMAi | SCENCIV |
OrthoDBi | 1191277at2759 |
TreeFami | TF314451 |
Enzyme and pathway databases
Reactomei | R-RNO-212300, PRC2 methylates histones and DNA R-RNO-2559580, Oxidative Stress Induced Senescence R-RNO-3214841, PKMTs methylate histone lysines R-RNO-8943724, Regulation of PTEN gene transcription R-RNO-8953750, Transcriptional Regulation by E2F6 |
Gene expression databases
Bgeei | ENSRNOG00000017509, Expressed in thymus and 21 other tissues |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR037352, Polycomb_EED IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10253:SF5, PTHR10253:SF5, 1 hit |
Pfami | View protein in Pfam PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B5DF02_RAT | |
Accessioni | B5DF02Primary (citable) accession number: B5DF02 Secondary accession number(s): F1LMC5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 14, 2008 |
Last sequence update: | October 14, 2008 | |
Last modified: | February 10, 2021 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |