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UniProtKB - B5DEY7 (B5DEY7_RAT)
Protein
Neurogenic differentiation factor
Gene
Neurod6
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
GO - Biological processi
- dentate gyrus development Source: RGD
- neuron differentiation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | ActivatorARBA annotation, Developmental proteinUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation |
Biological process | DifferentiationUniRule annotation, NeurogenesisUniRule annotationARBA annotation, Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Neurogenic differentiation factorUniRule annotation |
Gene namesi | Name:Neurod6Imported ORF Names:rCG_52313Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1562793, Neurod6 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000026055, Expressed in frontal cortex and 7 other tissues |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
ARBA annotationGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016182 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 94 – 146 | BHLHInterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 29 – 82 | DisorderedSequence analysisAdd BLAST | 54 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 100 – 120 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000159827 |
HOGENOMi | CLU_055134_1_0_1 |
OMAi | ANYPRES |
OrthoDBi | 1096531at2759 |
TreeFami | TF315153 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032650, Neurod6 IPR022575, Neurogenic_DUF IPR016637, TF_bHLH_NeuroD |
PANTHERi | PTHR19290:SF9, PTHR19290:SF9, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF12533, Neuro_bHLH, 1 hit |
PIRSFi | PIRSF015618, bHLH_NeuroD, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
B5DEY7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTLPFDESV VMPESQMCRK FARQCEDQKQ IKKPESFPKQ VVLRGKSIKR
60 70 80 90 100
APGEETEKEE EEEDREEEDE NGLPRRRGLR KKKTTKLRLE RVKFRRQEAN
110 120 130 140 150
ARERNRMHGL NDALDNLRKV VPCYSKTQKL SKIETLRLAK NYIWALSEIL
160 170 180 190 200
RIGKRPDLLT FVQNLCKGLS QPTTNLVAGC LQLNARSFLM GQGGEAAHHT
210 220 230 240 250
RSPYSTFYPP YHSPELATPP GHGTLDNSKS MKPYNYCSAY ESFYESTSPE
260 270 280 290 300
CASPQFEGPL SPPPINYNGI FSLKQEETLD YGKNYNYGMH YCAVPPRGPL
310 320 330
GQGAMFRLPT DSHFPYDLHL RSQSLTMQDE LNAVFHN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC168855 mRNA Translation: AAI68855.1 CH474011 Genomic DNA Translation: EDL88072.1 |
RefSeqi | NP_001102707.1, NM_001109237.1 |
Genome annotation databases
Ensembli | ENSRNOT00000016182.6; ENSRNOP00000016182.2; ENSRNOG00000026055.5 |
GeneIDi | 500137 |
KEGGi | rno:500137 |
UCSCi | RGD:1562793, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC168855 mRNA Translation: AAI68855.1 CH474011 Genomic DNA Translation: EDL88072.1 |
RefSeqi | NP_001102707.1, NM_001109237.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016182 |
Genome annotation databases
Ensembli | ENSRNOT00000016182.6; ENSRNOP00000016182.2; ENSRNOG00000026055.5 |
GeneIDi | 500137 |
KEGGi | rno:500137 |
UCSCi | RGD:1562793, rat |
Organism-specific databases
CTDi | 63974 |
RGDi | 1562793, Neurod6 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000159827 |
HOGENOMi | CLU_055134_1_0_1 |
OMAi | ANYPRES |
OrthoDBi | 1096531at2759 |
TreeFami | TF315153 |
Gene expression databases
Bgeei | ENSRNOG00000026055, Expressed in frontal cortex and 7 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032650, Neurod6 IPR022575, Neurogenic_DUF IPR016637, TF_bHLH_NeuroD |
PANTHERi | PTHR19290:SF9, PTHR19290:SF9, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF12533, Neuro_bHLH, 1 hit |
PIRSFi | PIRSF015618, bHLH_NeuroD, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B5DEY7_RAT | |
Accessioni | B5DEY7Primary (citable) accession number: B5DEY7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 14, 2008 |
Last sequence update: | October 14, 2008 | |
Last modified: | May 25, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |