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Entry version 68 (17 Jun 2020)
Sequence version 1 (14 Oct 2008)
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Protein

Tetratricopeptide repeat protein 17

Gene

Ttc17

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in primary ciliogenesis by modulating actin polymerization.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 17
Short name:
TPR repeat protein 17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ttc17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
1305410 Ttc17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004260081 – 1198Tetratricopeptide repeat protein 17Add BLAST1198

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B5DEL3

PeptideAtlas

More...
PeptideAtlasi
B5DEL3

PRoteomics IDEntifications database

More...
PRIDEi
B5DEL3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in germ cells as well as in somatic cells of the testis (at protein level). Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000010495 Expressed in liver and 9 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B5DEL3 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CATIP.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000014088

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B5DEL3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati295 – 328TPR 1Add BLAST34
Repeati619 – 652TPR 2Add BLAST34
Repeati689 – 722TPR 3Add BLAST34
Repeati1071 – 1105TPR 4Add BLAST35
Repeati1108 – 1141TPR 5Add BLAST34
Repeati1142 – 1175TPR 6Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili340 – 382Sequence analysisAdd BLAST43

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TTC17 family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4507 Eukaryota
ENOG410XSDX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006196

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008510_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B5DEL3

Identification of Orthologs from Complete Genome Data

More...
OMAi
DDHARQI

Database of Orthologous Groups

More...
OrthoDBi
310025at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B5DEL3

TreeFam database of animal gene trees

More...
TreeFami
TF315005

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181 TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B5DEL3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAIGVRGR FELLSCSGPG WLISLSALLS VVARGALATT HWVVTEDGKI
60 70 80 90 100
QQQVDSPMNL KHPHDLVILM RQETTVNYLK ELEKQLVAQK IHIEENEDRD
110 120 130 140 150
TGLEQRHNKE DPDCIKAKVP LGDLDLYDGT YITLESKDVR PEDFIDTESP
160 170 180 190 200
VPPDPEQPDC TKILELPYSI HAFQHLRGVQ ERVNLSAPLL PKEDPIFTYL
210 220 230 240 250
SKRLGRSIDD IGHLIHEGLQ KNSSSWVLYN LASFYWRIKN EPYQVVECTM
260 270 280 290 300
RALHFSSRHN KDIALVNLAN VLHRAHFSAD AAVVVHAALD DSAFFTSYYT
310 320 330 340 350
LGNIYAMLGE YNHSVLCYDH ALQAKPGFEQ AIKRKHAVLC QQKLEQKLEA
360 370 380 390 400
QHRSLQRTLN ELKEYQKQHD HYLRQQEILE KHKLIQEEQI LRNIIHETQM
410 420 430 440 450
AKEAQLGNHQ ICRLVNQQHS LHCQWDQPVR YHRGDIFENV DYVQFGDDSS
460 470 480 490 500
TSSMMSVNFD VPTNQSDVSE SVRSSPVAHS VLWVWGRDSD AYRDKQHILW
510 520 530 540 550
PKRADCTDSY PRVPLGGELP TYFLPPENKG LRIHELTSDD YSSEEEAQTP
560 570 580 590 600
DCSITDFRKS HTLSYLVKEL EVRMDLKAKI PDDHARKILL SRIKNYTIPE
610 620 630 640 650
EEIGSFLFHA INKPNAPVWL ILNEAGLYWR AVGNSTFAIA CLQRALNLAP
660 670 680 690 700
VQYQDIPLVN LANLLIHYGL HLDATKLLLQ ALAVNSSEPL TFLSLGNAYL
710 720 730 740 750
ALKNVSGALE AFRQALKLTT RCPECESSLK LIRCMQFYPF LYNITSSVCS
760 770 780 790 800
GHCHEKTLDN SHDKQKYFAK PQSLDAAEEE PSRHGADEDP VLSVENAGRD
810 820 830 840 850
SDALRLESTV VEESNGSDEV EKSEETKMSE EILALVDEFQ QAWPLEGLGG
860 870 880 890 900
TLEMKGRRLD LQGIRVLKKG PQDGVAKSSC YGDCRSEDDE ATEWITFQVK
910 920 930 940 950
RVKKPKGDHK KPPGKKVEAS QAENGQRYQA NLEITGPKVA SPGPQEKKRD
960 970 980 990 1000
YQSMGWPSPD ECLKLRWVEL TAIVSTWLAV SSKNIDITEH IDFATPIQQP
1010 1020 1030 1040 1050
AMEPLCNGNL PTSMHTLDHL HGVSNRASLH YTGESQLTEV LQNLGKDQYP
1060 1070 1080 1090 1100
QQSLEQIGTR IAKVLEKNQT SWVLSSMAAL YWRVKGQGKK AIDCLRQALH
1110 1120 1130 1140 1150
YAPHQMKDVP LISLANILHN AKLWNDAVVV ATMAVEIAPH FAVNHFTLGN
1160 1170 1180 1190
VYVAMEEFEK ALVWYESTLK LQPEFVPAKN RIQTIQCHLM LKKGRRSP
Length:1,198
Mass (Da):135,721
Last modified:October 14, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFDAB1ABF199D83AC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR06024800 Genomic DNA No translation available.
AABR06024801 Genomic DNA No translation available.
AABR06024802 Genomic DNA No translation available.
AABR06024803 Genomic DNA No translation available.
BC168714 mRNA Translation: AAI68714.1

NCBI Reference Sequences

More...
RefSeqi
NP_001101222.2, NM_001107752.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000014088; ENSRNOP00000014088; ENSRNOG00000010495

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
311224

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:311224

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06024800 Genomic DNA No translation available.
AABR06024801 Genomic DNA No translation available.
AABR06024802 Genomic DNA No translation available.
AABR06024803 Genomic DNA No translation available.
BC168714 mRNA Translation: AAI68714.1
RefSeqiNP_001101222.2, NM_001107752.2

3D structure databases

SMRiB5DEL3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014088

Proteomic databases

PaxDbiB5DEL3
PeptideAtlasiB5DEL3
PRIDEiB5DEL3

Genome annotation databases

EnsembliENSRNOT00000014088; ENSRNOP00000014088; ENSRNOG00000010495
GeneIDi311224
KEGGirno:311224

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55761
RGDi1305410 Ttc17

Phylogenomic databases

eggNOGiKOG4507 Eukaryota
ENOG410XSDX LUCA
GeneTreeiENSGT00390000006196
HOGENOMiCLU_008510_0_0_1
InParanoidiB5DEL3
OMAiDDHARQI
OrthoDBi310025at2759
PhylomeDBiB5DEL3
TreeFamiTF315005

Miscellaneous databases

Protein Ontology

More...
PROi
PR:B5DEL3

Gene expression databases

BgeeiENSRNOG00000010495 Expressed in liver and 9 other tissues
GenevisibleiB5DEL3 RN

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 7 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC17_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B5DEL3
Secondary accession number(s): F1MA48
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: October 14, 2008
Last modified: June 17, 2020
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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