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UniProtKB - B5DEH3 (B5DEH3_RAT)
Protein
Submitted name:
Sp2 protein
Gene
Sp2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- histone deacetylase binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- circulatory system development Source: RGD
- embryonic organ development Source: RGD
- fibroblast proliferation Source: RGD
- in utero embryonic development Source: RGD
- multicellular organism growth Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Sp2 proteinImportedSubmitted name: Sp2 transcription factor |
Gene namesi | Name:Sp2Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1592078, Sp2 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000010492, Expressed in skeletal muscle tissue and 21 other tissues |
Interactioni
GO - Molecular functioni
- histone deacetylase binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000059769 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 524 – 553 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 554 – 583 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 584 – 611 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 228 – 250 | DisorderedSequence analysisAdd BLAST | 23 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159590 |
HOGENOMi | CLU_034267_0_0_1 |
OMAi | IQYQTVP |
OrthoDBi | 1085860at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR030451, SP2_TF IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF1, PTHR23235:SF1, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B5DEH3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDSQMSMAA TAAVSPSDYL QPAAAATQDS QPSPLALLAA TCSKIGPPAV
60 70 80 90 100
EAAVTPPAPP QPTPRKLVPI KPAPLPLSPC KNSFSILSSK GNILQIQGSQ
110 120 130 140 150
LSASYPGGQF VFAIQNPTLI NKGSRSNASI QYQVPQIQGN SSQTIQVQPN
160 170 180 190 200
LTNQIQIIPG TNQAIITPST SGHKPVPIKP APVQKSNTTT TPVQSGANVV
210 220 230 240 250
KLTGGGGNMT LTLPLNNLVN TSDIGAPAQL LTESPPTPLS KTNKKARKKS
260 270 280 290 300
LPVSQPSVAV AEQVETVLIE TTAENIIQAG NNLLIVQSPG GGQPAVVQQV
310 320 330 340 350
QVVPPKAEQQ QVVQIPQQAL RVVQAASATL PTVPQKPSQN FQIQTTEPTP
360 370 380 390 400
TQVYIRTPSG EVQTVLVQDS PPATAATTST VSCSSPALRA PHLSGSSKKH
410 420 430 440 450
SAAILRKERP LPKIAPAGSI ISLNAAQLAA AAQAMQTINI NGVQVQGVPV
460 470 480 490 500
TITNTGGQQQ LTVQNVSGNN LTISGLSPTQ IQLQMEQALA GEAQPGEKRR
510 520 530 540 550
RMACTCPNCK DGEKRSGEQG KKKHVCHIPD CGKTFRKTSL LRAHVRLHTG
560 570 580 590 600
ERPFVCNWFF CGKRFTRSDE LQRHARTHTG DKRFECAQCQ KRFMRSDHLT
610
KHYKTHLGTK GL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3ZSM5 | D3ZSM5_RAT | Sp2 transcription factor | Sp2 | 636 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC168669 mRNA Translation: AAI68669.1 |
RefSeqi | XP_006247365.1, XM_006247303.3 |
Genome annotation databases
Ensembli | ENSRNOT00000087322.2; ENSRNOP00000072347.1; ENSRNOG00000010492.8 |
GeneIDi | 303499 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC168669 mRNA Translation: AAI68669.1 |
RefSeqi | XP_006247365.1, XM_006247303.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000059769 |
Genome annotation databases
Ensembli | ENSRNOT00000087322.2; ENSRNOP00000072347.1; ENSRNOG00000010492.8 |
GeneIDi | 303499 |
Organism-specific databases
CTDi | 6668 |
RGDi | 1592078, Sp2 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159590 |
HOGENOMi | CLU_034267_0_0_1 |
OMAi | IQYQTVP |
OrthoDBi | 1085860at2759 |
Gene expression databases
Bgeei | ENSRNOG00000010492, Expressed in skeletal muscle tissue and 21 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR030451, SP2_TF IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF1, PTHR23235:SF1, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | B5DEH3_RAT | |
Accessioni | B5DEH3Primary (citable) accession number: B5DEH3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 14, 2008 |
Last sequence update: | October 14, 2008 | |
Last modified: | May 25, 2022 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |