Sp2

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
histone deacetylase binding Source: Ensembl
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism growth Source: InterPro
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Sp2 proteinImported Submitted name: Sp2 transcription factorImported
Gene namesⁱ	Name:Sp2Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 10

Organism-specific databases

Rat genome database More...RGDⁱ	1592078 Sp2

RGDⁱ

1592078 Sp2

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000010492 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000010492 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Interactionⁱ

GO - Molecular functionⁱ

histone deacetylase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000059769

STRINGⁱ

10116.ENSRNOP00000059769

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	524 – 553	C2H2-typeInterPro annotationAdd BLAST	30
Domainⁱ	554 – 583	C2H2-typeInterPro annotationAdd BLAST	30
Domainⁱ	584 – 611	C2H2-typeInterPro annotationAdd BLAST	28

Keywords - Domainⁱ

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000234295
HOVERGENⁱ	HBG008933
OMAⁱ	PNCKDAD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HX6

Family and domain databases

InterProⁱ	View protein in InterPro IPR030451 SP2_TF IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR23235:SF1 PTHR23235:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

B5DEH3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSDSQMSMAA TAAVSPSDYL QPAAAATQDS QPSPLALLAA TCSKIGPPAV 
        60         70         80         90        100
EAAVTPPAPP QPTPRKLVPI KPAPLPLSPC KNSFSILSSK GNILQIQGSQ 
       110        120        130        140        150
LSASYPGGQF VFAIQNPTLI NKGSRSNASI QYQVPQIQGN SSQTIQVQPN 
       160        170        180        190        200
LTNQIQIIPG TNQAIITPST SGHKPVPIKP APVQKSNTTT TPVQSGANVV 
       210        220        230        240        250
KLTGGGGNMT LTLPLNNLVN TSDIGAPAQL LTESPPTPLS KTNKKARKKS 
       260        270        280        290        300
LPVSQPSVAV AEQVETVLIE TTAENIIQAG NNLLIVQSPG GGQPAVVQQV 
       310        320        330        340        350
QVVPPKAEQQ QVVQIPQQAL RVVQAASATL PTVPQKPSQN FQIQTTEPTP 
       360        370        380        390        400
TQVYIRTPSG EVQTVLVQDS PPATAATTST VSCSSPALRA PHLSGSSKKH 
       410        420        430        440        450
SAAILRKERP LPKIAPAGSI ISLNAAQLAA AAQAMQTINI NGVQVQGVPV 
       460        470        480        490        500
TITNTGGQQQ LTVQNVSGNN LTISGLSPTQ IQLQMEQALA GEAQPGEKRR 
       510        520        530        540        550
RMACTCPNCK DGEKRSGEQG KKKHVCHIPD CGKTFRKTSL LRAHVRLHTG 
       560        570        580        590        600
ERPFVCNWFF CGKRFTRSDE LQRHARTHTG DKRFECAQCQ KRFMRSDHLT 
       610 
KHYKTHLGTK GL

Length:612

Mass (Da):64,861

Last modified:October 14, 2008 - v1

Checksum:ⁱ8AC3706E91C1F667

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3ZSM5	D3ZSM5_RAT		Sp2 transcription factor Sp2 transcription factor (Sp2 transcription factor (Mapped), isoform CRA_a)	Sp2 Sp2_mapped, rCG_34324	404	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07030423 Genomic DNA No translation available. BC168669 mRNA Translation: AAI68669.1
NCBI Reference Sequences More...RefSeqⁱ	XP_006247365.1, XM_006247303.3
UniGeneⁱ	Rn.229752

Genome annotation databases

Ensemblⁱ	ENSRNOT00000087322; ENSRNOP00000072347; ENSRNOG00000010492
GeneIDⁱ	303499

Protein	Similar proteins		Species	Score	Length	Source
B5DEH3	Sp2 transcription factor		RAT		404	UniRef100_B5DEH3

Protein	Similar proteins		Species	Score	Length	Source
B5DEH3	Transcription factor Sp2		HUMAN		613	UniRef90_Q02086
Transcription factor Sp2		BOVIN		613
Transcription factor Sp2		MOUSE		612
SP2 isoform 1		PONAB		613
Sp2 transcription factor		GORGO		613
+177

Protein	Similar proteins		Species	Score	Length	Source
B5DEH3	Transcription factor Sp2		HUMAN		613	UniRef50_Q02086
Transcription factor Sp2		BOVIN		613
Transcription factor Sp2		MOUSE		612
SP2 isoform 1		PONAB		613
Sp2 transcription factor		GORGO		613
+413

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07030423 Genomic DNA No translation available. BC168669 mRNA Translation: AAI68669.1
RefSeqⁱ	XP_006247365.1, XM_006247303.3
UniGeneⁱ	Rn.229752

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000059769

STRINGⁱ

10116.ENSRNOP00000059769

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000087322; ENSRNOP00000072347; ENSRNOG00000010492
GeneIDⁱ	303499

Organism-specific databases

CTDⁱ	6668
RGDⁱ	1592078 Sp2

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000234295
HOVERGENⁱ	HBG008933
OMAⁱ	PNCKDAD
OrthoDBⁱ	EOG091G0HX6

Gene expression databases

Bgeeⁱ	ENSRNOG00000010492 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000010492 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProⁱ	View protein in InterPro IPR030451 SP2_TF IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR23235:SF1 PTHR23235:SF1, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B5DEH3_RAT
Accessionⁱ	B5DEH3Primary (citable) accession number: B5DEH3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 14, 2008
	Last sequence update:	October 14, 2008
	Last modified:	November 7, 2018
	This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B5DEH3 (B5DEH3_RAT)

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Sp2 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ