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Protein

Erlin-2

Gene

Erlin2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity).By similarity

GO - Molecular functioni

  • cholesterol binding Source: GO_Central
  • ubiquitin protein ligase binding Source: Ensembl

GO - Biological processi

Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Enzyme and pathway databases

ReactomeiR-RNO-382556 ABC-family proteins mediated transport

Names & Taxonomyi

Protein namesi
Recommended name:
Erlin-2By similarity
Alternative name(s):
Endoplasmic reticulum lipid raft-associated protein 2By similarityImported
Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2By similarity
Short name:
SPFH domain-containing protein 2By similarityImported
Gene namesi
Name:Erlin2Imported
Synonyms:Spfh2By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1309010 Erlin2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3CytoplasmicSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 339ExtracellularSequence analysisAdd BLAST315

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003712301 – 339Erlin-2Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei267N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiB5DEH2
PeptideAtlasiB5DEH2
PRIDEiB5DEH2

PTM databases

iPTMnetiB5DEH2
PhosphoSitePlusiB5DEH2

Expressioni

Gene expression databases

BgeeiENSRNOG00000013763 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
GenevisibleiB5DEH2 RN

Interactioni

Subunit structurei

Forms a heteromeric complex with ERLIN1. In complex with ERLIN1, interacts with RNF170. Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination. Interacts with SCAP, INSIG1, SREBF1 and SREBF2 under cholesterol sufficiency conditions; indicative for an association with the SCAP-SREBP-INSIG complex. Probably part of an AMFR/gp78 and INSIG1-containing ubiquitin ligase complex involved in ERAD of HMGCR. Interacts with TMUB1; TMUB1 bridges the association with AMFR. Interacts with SYVN1 and RNF139. Interacts with TMEM259 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi253334, 7 interactors
IntActiB5DEH2, 2 interactors
STRINGi10116.ENSRNOP00000018973

Structurei

3D structure databases

SMRiB5DEH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni177 – 309Interaction with ERLIN1By similarityAdd BLAST133

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Sequence analysis

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2962 Eukaryota
ENOG410XQSH LUCA
GeneTreeiENSGT00390000014666
HOGENOMiHOG000251613
InParanoidiB5DEH2
OMAiVVNFLIQ
OrthoDBiEOG091G037D
PhylomeDBiB5DEH2
TreeFamiTF313059

Family and domain databases

CDDicd03406 SPFH_like_u3, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR033294 Erlin1/2
PANTHERiPTHR15351 PTHR15351, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
SMARTiView protein in SMART
SM00244 PHB, 1 hit

Sequencei

Sequence statusi: Complete.

B5DEH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQLGAVVAV ASSFFCASLF SAVHKIEEGH IGVYYRGGAL LTSTSGPGFH
60 70 80 90 100
LMLPFITSYK SVQTTLQTDE VKNVPCGTSG GVMIYFDRIE VVNFLVPHAV
110 120 130 140 150
YDIVKNYTAD YDKALIFNKI HHELNQFCSV HTLQEVYIEL FDQIDENLKL
160 170 180 190 200
ALQQDLTSMA PGLVIQAVRV TKPNIPEAIR RNYELMESEK TKLLIAAQKQ
210 220 230 240 250
KVVEKEAETE RKKALIEAEK VAQVAEITYG QKVMEKETEK KISEIEDAAF
260 270 280 290 300
LAREKAKADA ECYTALKIAE ANKLKLTPEY LQLMKYKAIA SNSKIYFGKD
310 320 330
IPNMFMDSAG GLGKQSEGLS DKLGFGLEDE PLETATKDN
Length:339
Mass (Da):37,710
Last modified:October 14, 2008 - v1
Checksum:iA777F11C4B1A47D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473970 Genomic DNA Translation: EDM09088.1
BC168668 mRNA Translation: AAI68668.1
RefSeqiNP_001099558.1, NM_001106088.2
XP_008769545.1, XM_008771323.2
XP_008769546.1, XM_008771324.2
UniGeneiRn.12619

Genome annotation databases

EnsembliENSRNOT00000018973; ENSRNOP00000018973; ENSRNOG00000013763
GeneIDi290823
KEGGirno:290823
UCSCiRGD:1309010 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473970 Genomic DNA Translation: EDM09088.1
BC168668 mRNA Translation: AAI68668.1
RefSeqiNP_001099558.1, NM_001106088.2
XP_008769545.1, XM_008771323.2
XP_008769546.1, XM_008771324.2
UniGeneiRn.12619

3D structure databases

SMRiB5DEH2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi253334, 7 interactors
IntActiB5DEH2, 2 interactors
STRINGi10116.ENSRNOP00000018973

PTM databases

iPTMnetiB5DEH2
PhosphoSitePlusiB5DEH2

Proteomic databases

PaxDbiB5DEH2
PeptideAtlasiB5DEH2
PRIDEiB5DEH2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018973; ENSRNOP00000018973; ENSRNOG00000013763
GeneIDi290823
KEGGirno:290823
UCSCiRGD:1309010 rat

Organism-specific databases

CTDi11160
RGDi1309010 Erlin2

Phylogenomic databases

eggNOGiKOG2962 Eukaryota
ENOG410XQSH LUCA
GeneTreeiENSGT00390000014666
HOGENOMiHOG000251613
InParanoidiB5DEH2
OMAiVVNFLIQ
OrthoDBiEOG091G037D
PhylomeDBiB5DEH2
TreeFamiTF313059

Enzyme and pathway databases

ReactomeiR-RNO-382556 ABC-family proteins mediated transport

Miscellaneous databases

PROiPR:B5DEH2

Gene expression databases

BgeeiENSRNOG00000013763 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
GenevisibleiB5DEH2 RN

Family and domain databases

CDDicd03406 SPFH_like_u3, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR033294 Erlin1/2
PANTHERiPTHR15351 PTHR15351, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
SMARTiView protein in SMART
SM00244 PHB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERLN2_RAT
AccessioniPrimary (citable) accession number: B5DEH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 14, 2008
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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