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Entry version 81 (02 Dec 2020)
Sequence version 1 (14 Oct 2008)
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Protein

Protein-tyrosine-phosphatase

Gene

ptprb

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphataseARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-tyrosine-phosphataseARBA annotation (EC:3.1.3.48ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ptprbImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-991728, ptprb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1897 – 1923HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 43Ricin B-type lectinInterPro annotationAdd BLAST43
Domaini278 – 376Ig-likeInterPro annotationAdd BLAST99
Domaini393 – 486Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini569 – 660Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini661 – 749Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini750 – 842Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini923 – 1017Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1102 – 1186Fibronectin type-IIIInterPro annotationAdd BLAST85
Domaini1187 – 1281Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1368 – 1455Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini1456 – 1543Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini1544 – 1637Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1638 – 1729Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini1988 – 2248Tyrosine-protein phosphataseInterPro annotationAdd BLAST261
Domaini2163 – 2239TYR_PHOSPHATASE_2InterPro annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni98 – 251DisorderedSequence analysisAdd BLAST154

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi108 – 152Pro-richSequence analysisAdd BLAST45
Compositional biasi153 – 251PolarSequence analysisAdd BLAST99

Keywords - Domaini

Immunoglobulin domainARBA annotation, RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
411281at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 10 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 15 hits
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR013783, Ig-like_fold
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR041201, PTPRJ_TM
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 13 hits
PF18861, PTP_tm, 1 hit
PF00102, Y_phosphatase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00700, PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 16 hits
SM00194, PTPc, 1 hit
SM00404, PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 16 hits
SSF50370, SSF50370, 1 hit
SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 11 hits
PS50835, IG_LIKE, 1 hit
PS50231, RICIN_B_LECTIN, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50055, TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B5DED6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSRGQQWKW TENGKLQHMK SAMCLGISNS SAAHSRPALM LSCFKAPKWT
60 70 80 90 100
CYENLLEVAE TSLFLRKQGP RLVVRKGMKY PNTWRRIEVD DQGVATNWSL
110 120 130 140 150
CTEPPTNSPS TIKPPTNRPS TTKPPTNRPS TTKPPTNRPS TTKPPTNRPS
160 170 180 190 200
TTKPPTNRPS TTKPSTNRPS TAKSPTNRSS TTKSPTNRPS TTKPPTNRSS
210 220 230 240 250
TAESPTNRSS TTKSPTNSTS TTMPLTKNPS ITKPPTNHPS PTTNDVSNGT
260 270 280 290 300
SRPLILMANS TELNSPNGTS WYVSDLSPTV ATDVFLPTTT QLNENSIAEN
310 320 330 340 350
VEPVKCTINN TDVTVTSQSI YLEWTSPGSH CNFSLTCSSH NFWEITCNPI
360 370 380 390 400
QKSNDSYECT LSGLEAGTVF DLRIVSLQDG EMKNLSLQTD PLPPSNFVVN
410 420 430 440 450
KNSVTSSSVQ ANWAPSSGKV DLYKVKLLDS KKEIVQEIEV SGISLTKEVT
460 470 480 490 500
FKNLTPGTKY SIEITAISGN KRSPTSVINA STVPSTVKSI DANSKTDTID
510 520 530 540 550
ASWKPGHGNI DSYKLILLNE DRKITEVVLE QNITSYSFHG LLPGYVYNLT
560 570 580 590 600
VISEAAGLRT WNSKLIRTAP AEVQAISVQS DGRTDALKVQ WKEPRGKLDF
610 620 630 640 650
YNVTLSDTGS IKYSRTVHPG TPTEITFTGL TPGHLYQVGI STIAGELSTS
660 670 680 690 700
RMATGQTIPE KVADLKAVSN GLRSLRLSWV PPSGDWDKYN IVLYNNTAVL
710 720 730 740 750
VNTTIDKKYR EYVIQDIGLI PGRQYEAVVI VESGKFKNLA RCKGRTAPPA
760 770 780 790 800
VMDLRLKHAN ESSLTIMWVM PVAEWDNYVV SLADRDLTPV NKVLSKEAKE
810 820 830 840 850
FTFNHLAQGR KYIATVTSIS GDLSSRASVE GRTVPAQVTN LNVENQGTTS
860 870 880 890 900
SLHADWTKAP GDVDSYQVLL IHEKIVIKNE TVSNEINKYS FHSLKPGGLY
910 920 930 940 950
SVVVTTVSGG ISSRQTVSEG RTVPSSVNRV TINNFGRSDY LSISWQPAAG
960 970 980 990 1000
DVDIYFVTLS HQNNILPSLA ISKSVNECSF SSLTAGRLYN VTVTTKSGKY
1010 1020 1030 1040 1050
ENHSYSQEWT VPSAVQGLAV NNAARSDYLK ASWLRAVGDF DIYQVTIKNN
1060 1070 1080 1090 1100
NDFIQIKDVT KTENECVFTN LVPGRLYSIT VMTKSGNYKA SAMASGRTFP
1110 1120 1130 1140 1150
EAVKKLTLAE RSSEELHVTW SRADGDVDHY EIQLLFNDMK VFPPITLNNT
1160 1170 1180 1190 1200
ADEYKFTSLT PGRLYKIVVL TFSGEAQRAM FVEALTVPST VKNIHISPNG
1210 1220 1230 1240 1250
MTNSLKVNWT PGGGDVDSYT VSIFHHNSPI GSHTTSKHIF EHTFQNLNPG
1260 1270 1280 1290 1300
ELYKVDVQTN SGSLHKSLES FGRTIPATVH SLSADNAYSS HLLIVSWQSA
1310 1320 1330 1340 1350
KGVTDRYDIL LLSDHGIVIT NKSVPIMAKS HKFEDLVPGK KYRIQVFTVS
1360 1370 1380 1390 1400
GGLFSAAVET EGQTVPAAVS DVKITGNSTD SLSFTWNSSE GELDSYGIFL
1410 1420 1430 1440 1450
YNPDNSLHDR KSGNPDLRHC SFQGLLPGRL YKMVIVTHSG SLTNESSIHG
1460 1470 1480 1490 1500
RTVPAPVSSL QVSNRNTSES LWFTWAPALG DVDIYELILY NPNGTEKEKI
1510 1520 1530 1540 1550
QDKDLTESHF QNLVPGRLYT LVIFTHSGDL FNKATAVGRT APQPPNSVSF
1560 1570 1580 1590 1600
ADVKINSLSI MWLGPPDWTD YDDFELQWSP KDLLVVVNPY SIGRSKGRII
1610 1620 1630 1640 1650
NGLYPGRQYT FGVQSVSGNT GKTLSPAIFG TVRTKPDKIH HLHCRPQTST
1660 1670 1680 1690 1700
AISCSWTPPD SDFDGYSVEC RRNGSDDVEF SKRIEKDKSS ITISTLVPHK
1710 1720 1730 1740 1750
RYVVSIKVHS ADMTSQVIED SAITMIDRPP PPPLLIRVNK KDTFISKSSI
1760 1770 1780 1790 1800
HFRFNCSWFS DTNGAVKYFT VIVSEADGND NQRPEASLPL PSYADYKTNK
1810 1820 1830 1840 1850
STKIYQTSYF PSRCAENPDY NIQSYKIKLG TGMELLGGKC DQNENKYCDG
1860 1870 1880 1890 1900
PLSPRTSYRI SVRAFTQLFT EEMRTFPEPL YSDTFFSLPI TTEAEPLFGV
1910 1920 1930 1940 1950
IEGVSGGMFV IIMIIVLTVL LIYRQKKKRV YEQDPMTTHL SSQIERIPSV
1960 1970 1980 1990 2000
HLNVGHIQIG DRISSRPILT AQFEEHFSKL QTDSNYLLSR EYENLKDFGR
2010 2020 2030 2040 2050
DQSSDTALLP ENRGKNRYSN ILPYDSTRVK LANVDDDPCS DYINASYMPG
2060 2070 2080 2090 2100
INFRREYIAT QGPLPATKDD FWKMVWEQNV HIIVMVTQCT ERGRAKCDHY
2110 2120 2130 2140 2150
WPMDQDSYYY GDLIVQMLSE SVLPEWTIRE FKICSEDQID APRLVRHFHY
2160 2170 2180 2190 2200
TVWPDHGVPE TTQSLIQFVR TVRDYINRTP GSGPTVVHCS AGVGRTGTFI
2210 2220 2230 2240 2250
VLDRMLQQVD TVDSVDIFGA VRDLRIHRMY MVQTECQYVY LYQCVRDVLR
2260 2270 2280
ARKLRNEQDN PLFPIYENVN PEYHRDAVYL RH
Length:2,282
Mass (Da):254,093
Last modified:October 14, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB01B820113265277
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC168627 mRNA Translation: AAI68627.1

NCBI Reference Sequences

More...
RefSeqi
NP_001131088.2, NM_001137616.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100192375

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:100192375

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168627 mRNA Translation: AAI68627.1
RefSeqiNP_001131088.2, NM_001137616.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi100192375
KEGGixtr:100192375

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5787
XenbaseiXB-GENE-991728, ptprb

Phylogenomic databases

OrthoDBi411281at2759

Family and domain databases

CDDicd00063, FN3, 10 hits
Gene3Di2.60.40.10, 15 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR013783, Ig-like_fold
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR041201, PTPRJ_TM
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041, fn3, 13 hits
PF18861, PTP_tm, 1 hit
PF00102, Y_phosphatase, 1 hit
PRINTSiPR00700, PRTYPHPHTASE
SMARTiView protein in SMART
SM00060, FN3, 16 hits
SM00194, PTPc, 1 hit
SM00404, PTPc_motif, 1 hit
SUPFAMiSSF49265, SSF49265, 16 hits
SSF50370, SSF50370, 1 hit
SSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50853, FN3, 11 hits
PS50835, IG_LIKE, 1 hit
PS50231, RICIN_B_LECTIN, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50055, TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB5DED6_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B5DED6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: December 2, 2020
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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