UniProtKB - B5DED6 (B5DED6_XENTR)
Protein
Protein-tyrosine-phosphatase
Gene
ptprb
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Catalytic activityi
- EC:3.1.3.48ARBA annotation
GO - Molecular functioni
- protein tyrosine phosphatase activity Source: GO_Central
GO - Biological processi
- protein dephosphorylation Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protein phosphataseARBA annotation |
Ligand | LectinARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ptprbImported |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Organism-specific databases
Xenbasei | XB-GENE-991728, ptprb |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1897 – 1923 | HelicalSequence analysisAdd BLAST | 27 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 43 | Ricin B-type lectinInterPro annotationAdd BLAST | 43 | |
Domaini | 278 – 376 | Ig-likeInterPro annotationAdd BLAST | 99 | |
Domaini | 393 – 486 | Fibronectin type-IIIInterPro annotationAdd BLAST | 94 | |
Domaini | 569 – 660 | Fibronectin type-IIIInterPro annotationAdd BLAST | 92 | |
Domaini | 661 – 749 | Fibronectin type-IIIInterPro annotationAdd BLAST | 89 | |
Domaini | 750 – 842 | Fibronectin type-IIIInterPro annotationAdd BLAST | 93 | |
Domaini | 923 – 1017 | Fibronectin type-IIIInterPro annotationAdd BLAST | 95 | |
Domaini | 1102 – 1186 | Fibronectin type-IIIInterPro annotationAdd BLAST | 85 | |
Domaini | 1187 – 1281 | Fibronectin type-IIIInterPro annotationAdd BLAST | 95 | |
Domaini | 1368 – 1455 | Fibronectin type-IIIInterPro annotationAdd BLAST | 88 | |
Domaini | 1456 – 1543 | Fibronectin type-IIIInterPro annotationAdd BLAST | 88 | |
Domaini | 1544 – 1637 | Fibronectin type-IIIInterPro annotationAdd BLAST | 94 | |
Domaini | 1638 – 1729 | Fibronectin type-IIIInterPro annotationAdd BLAST | 92 | |
Domaini | 1988 – 2248 | Tyrosine-protein phosphataseInterPro annotationAdd BLAST | 261 | |
Domaini | 2163 – 2239 | TYR_PHOSPHATASE_2InterPro annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 98 – 251 | DisorderedSequence analysisAdd BLAST | 154 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 108 – 152 | Pro-richSequence analysisAdd BLAST | 45 | |
Compositional biasi | 153 – 251 | PolarSequence analysisAdd BLAST | 99 |
Keywords - Domaini
Immunoglobulin domainARBA annotation, RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
OrthoDBi | 411281at2759 |
Family and domain databases
CDDi | cd00063, FN3, 9 hits |
Gene3Di | 2.60.40.10, 15 hits 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR013783, Ig-like_fold IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR041201, PTPRJ_TM IPR035992, Ricin_B-like_lectins IPR000772, Ricin_B_lectin IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00041, fn3, 13 hits PF18861, PTP_tm, 1 hit PF00102, Y_phosphatase, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 16 hits SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF49265, SSF49265, 16 hits SSF50370, SSF50370, 1 hit SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 11 hits PS50835, IG_LIKE, 1 hit PS50231, RICIN_B_LECTIN, 1 hit PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
i Sequence
Sequence statusi: Complete.
B5DED6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSRGQQWKW TENGKLQHMK SAMCLGISNS SAAHSRPALM LSCFKAPKWT
60 70 80 90 100
CYENLLEVAE TSLFLRKQGP RLVVRKGMKY PNTWRRIEVD DQGVATNWSL
110 120 130 140 150
CTEPPTNSPS TIKPPTNRPS TTKPPTNRPS TTKPPTNRPS TTKPPTNRPS
160 170 180 190 200
TTKPPTNRPS TTKPSTNRPS TAKSPTNRSS TTKSPTNRPS TTKPPTNRSS
210 220 230 240 250
TAESPTNRSS TTKSPTNSTS TTMPLTKNPS ITKPPTNHPS PTTNDVSNGT
260 270 280 290 300
SRPLILMANS TELNSPNGTS WYVSDLSPTV ATDVFLPTTT QLNENSIAEN
310 320 330 340 350
VEPVKCTINN TDVTVTSQSI YLEWTSPGSH CNFSLTCSSH NFWEITCNPI
360 370 380 390 400
QKSNDSYECT LSGLEAGTVF DLRIVSLQDG EMKNLSLQTD PLPPSNFVVN
410 420 430 440 450
KNSVTSSSVQ ANWAPSSGKV DLYKVKLLDS KKEIVQEIEV SGISLTKEVT
460 470 480 490 500
FKNLTPGTKY SIEITAISGN KRSPTSVINA STVPSTVKSI DANSKTDTID
510 520 530 540 550
ASWKPGHGNI DSYKLILLNE DRKITEVVLE QNITSYSFHG LLPGYVYNLT
560 570 580 590 600
VISEAAGLRT WNSKLIRTAP AEVQAISVQS DGRTDALKVQ WKEPRGKLDF
610 620 630 640 650
YNVTLSDTGS IKYSRTVHPG TPTEITFTGL TPGHLYQVGI STIAGELSTS
660 670 680 690 700
RMATGQTIPE KVADLKAVSN GLRSLRLSWV PPSGDWDKYN IVLYNNTAVL
710 720 730 740 750
VNTTIDKKYR EYVIQDIGLI PGRQYEAVVI VESGKFKNLA RCKGRTAPPA
760 770 780 790 800
VMDLRLKHAN ESSLTIMWVM PVAEWDNYVV SLADRDLTPV NKVLSKEAKE
810 820 830 840 850
FTFNHLAQGR KYIATVTSIS GDLSSRASVE GRTVPAQVTN LNVENQGTTS
860 870 880 890 900
SLHADWTKAP GDVDSYQVLL IHEKIVIKNE TVSNEINKYS FHSLKPGGLY
910 920 930 940 950
SVVVTTVSGG ISSRQTVSEG RTVPSSVNRV TINNFGRSDY LSISWQPAAG
960 970 980 990 1000
DVDIYFVTLS HQNNILPSLA ISKSVNECSF SSLTAGRLYN VTVTTKSGKY
1010 1020 1030 1040 1050
ENHSYSQEWT VPSAVQGLAV NNAARSDYLK ASWLRAVGDF DIYQVTIKNN
1060 1070 1080 1090 1100
NDFIQIKDVT KTENECVFTN LVPGRLYSIT VMTKSGNYKA SAMASGRTFP
1110 1120 1130 1140 1150
EAVKKLTLAE RSSEELHVTW SRADGDVDHY EIQLLFNDMK VFPPITLNNT
1160 1170 1180 1190 1200
ADEYKFTSLT PGRLYKIVVL TFSGEAQRAM FVEALTVPST VKNIHISPNG
1210 1220 1230 1240 1250
MTNSLKVNWT PGGGDVDSYT VSIFHHNSPI GSHTTSKHIF EHTFQNLNPG
1260 1270 1280 1290 1300
ELYKVDVQTN SGSLHKSLES FGRTIPATVH SLSADNAYSS HLLIVSWQSA
1310 1320 1330 1340 1350
KGVTDRYDIL LLSDHGIVIT NKSVPIMAKS HKFEDLVPGK KYRIQVFTVS
1360 1370 1380 1390 1400
GGLFSAAVET EGQTVPAAVS DVKITGNSTD SLSFTWNSSE GELDSYGIFL
1410 1420 1430 1440 1450
YNPDNSLHDR KSGNPDLRHC SFQGLLPGRL YKMVIVTHSG SLTNESSIHG
1460 1470 1480 1490 1500
RTVPAPVSSL QVSNRNTSES LWFTWAPALG DVDIYELILY NPNGTEKEKI
1510 1520 1530 1540 1550
QDKDLTESHF QNLVPGRLYT LVIFTHSGDL FNKATAVGRT APQPPNSVSF
1560 1570 1580 1590 1600
ADVKINSLSI MWLGPPDWTD YDDFELQWSP KDLLVVVNPY SIGRSKGRII
1610 1620 1630 1640 1650
NGLYPGRQYT FGVQSVSGNT GKTLSPAIFG TVRTKPDKIH HLHCRPQTST
1660 1670 1680 1690 1700
AISCSWTPPD SDFDGYSVEC RRNGSDDVEF SKRIEKDKSS ITISTLVPHK
1710 1720 1730 1740 1750
RYVVSIKVHS ADMTSQVIED SAITMIDRPP PPPLLIRVNK KDTFISKSSI
1760 1770 1780 1790 1800
HFRFNCSWFS DTNGAVKYFT VIVSEADGND NQRPEASLPL PSYADYKTNK
1810 1820 1830 1840 1850
STKIYQTSYF PSRCAENPDY NIQSYKIKLG TGMELLGGKC DQNENKYCDG
1860 1870 1880 1890 1900
PLSPRTSYRI SVRAFTQLFT EEMRTFPEPL YSDTFFSLPI TTEAEPLFGV
1910 1920 1930 1940 1950
IEGVSGGMFV IIMIIVLTVL LIYRQKKKRV YEQDPMTTHL SSQIERIPSV
1960 1970 1980 1990 2000
HLNVGHIQIG DRISSRPILT AQFEEHFSKL QTDSNYLLSR EYENLKDFGR
2010 2020 2030 2040 2050
DQSSDTALLP ENRGKNRYSN ILPYDSTRVK LANVDDDPCS DYINASYMPG
2060 2070 2080 2090 2100
INFRREYIAT QGPLPATKDD FWKMVWEQNV HIIVMVTQCT ERGRAKCDHY
2110 2120 2130 2140 2150
WPMDQDSYYY GDLIVQMLSE SVLPEWTIRE FKICSEDQID APRLVRHFHY
2160 2170 2180 2190 2200
TVWPDHGVPE TTQSLIQFVR TVRDYINRTP GSGPTVVHCS AGVGRTGTFI
2210 2220 2230 2240 2250
VLDRMLQQVD TVDSVDIFGA VRDLRIHRMY MVQTECQYVY LYQCVRDVLR
2260 2270 2280
ARKLRNEQDN PLFPIYENVN PEYHRDAVYL RH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC168627 mRNA Translation: AAI68627.1 |
RefSeqi | NP_001131088.2, NM_001137616.1 |
Genome annotation databases
GeneIDi | 100192375 |
KEGGi | xtr:100192375 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC168627 mRNA Translation: AAI68627.1 |
RefSeqi | NP_001131088.2, NM_001137616.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 100192375 |
KEGGi | xtr:100192375 |
Organism-specific databases
CTDi | 5787 |
Xenbasei | XB-GENE-991728, ptprb |
Phylogenomic databases
OrthoDBi | 411281at2759 |
Family and domain databases
CDDi | cd00063, FN3, 9 hits |
Gene3Di | 2.60.40.10, 15 hits 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR013783, Ig-like_fold IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR041201, PTPRJ_TM IPR035992, Ricin_B-like_lectins IPR000772, Ricin_B_lectin IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00041, fn3, 13 hits PF18861, PTP_tm, 1 hit PF00102, Y_phosphatase, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 16 hits SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF49265, SSF49265, 16 hits SSF50370, SSF50370, 1 hit SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 11 hits PS50835, IG_LIKE, 1 hit PS50231, RICIN_B_LECTIN, 1 hit PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B5DED6_XENTR | |
Accessioni | B5DED6Primary (citable) accession number: B5DED6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 14, 2008 |
Last sequence update: | October 14, 2008 | |
Last modified: | April 7, 2021 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |