UniProtKB - B5D5N9 (CTR2_RAT)
Protein
Cationic amino acid transporter 2
Gene
Slc7a2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). The affinity for its substrates differs between isoforms created by alternative splicing. May play a role in classical or alternative activation of macrophages via its role in arginine transport.By similarity
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: RGD
- arginine transmembrane transporter activity Source: RGD
- high-affinity arginine transmembrane transporter activity Source: RGD
- high-affinity L-ornithine transmembrane transporter activity Source: RGD
- high-affinity lysine transmembrane transporter activity Source: RGD
- L-amino acid transmembrane transporter activity Source: RGD
- L-arginine transmembrane transporter activity Source: RGD
- L-lysine transmembrane transporter activity Source: RGD
- L-ornithine transmembrane transporter activity Source: RGD
- low-affinity L-arginine transmembrane transporter activity Source: RGD
GO - Biological processi
- amino acid import across plasma membrane Source: RGD
- amino acid transport Source: GO_Central
- arginine transport Source: RGD
- L-alpha-amino acid transmembrane transport Source: RGD
- L-amino acid transport Source: RGD
- L-arginine import across plasma membrane Source: RGD
- L-arginine transport Source: RGD
- L-lysine import across plasma membrane Source: RGD
- L-ornithine import across plasma membrane Source: RGD
- L-ornithine transmembrane transport Source: RGD
- macrophage activation Source: RGD
- nitric oxide biosynthetic process Source: RGD
- nitric oxide production involved in inflammatory response Source: RGD
- regulation of inflammatory response Source: RGD
- regulation of macrophage activation Source: RGD
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-352230, Amino acid transport across the plasma membrane |
Names & Taxonomyi
Protein namesi | Recommended name: Cationic amino acid transporter 2Short name: CAT-2 Short name: CAT2 Alternative name(s): Low affinity cationic amino acid transporter 2 Solute carrier family 7 member 2 |
Gene namesi | Name:Slc7a2 Synonyms:Atrc2, Cat2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 68387, Slc7a2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell junction Source: Ensembl
- integral component of membrane Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | CytoplasmicSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 59 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 60 – 66 | ExtracellularSequence analysis | 7 | |
Transmembranei | 67 – 87 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 88 – 104 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 105 – 125 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 126 – 163 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 185 – 192 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 193 – 213 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 214 – 248 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 249 – 269 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 270 – 289 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 290 – 310 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 311 – 339 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 340 – 360 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 361 – 385 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 386 – 406 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 407 – 409 | ExtracellularSequence analysis | 3 | |
Transmembranei | 410 – 430 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 431 – 489 | CytoplasmicSequence analysisAdd BLAST | 59 | |
Transmembranei | 490 – 510 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 511 – 523 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 524 – 544 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 545 – 554 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 555 – 575 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 576 – 581 | ExtracellularSequence analysis | 6 | |
Transmembranei | 582 – 602 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 603 – 657 | CytoplasmicSequence analysisAdd BLAST | 55 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000375227 | 1 – 657 | Cationic amino acid transporter 2Add BLAST | 657 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 157 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 227 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 239 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 463 | PhosphoserineBy similarity | 1 | |
Modified residuei | 645 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | B5D5N9 |
PeptideAtlasi | B5D5N9 |
PRIDEi | B5D5N9 |
PTM databases
GlyGeni | B5D5N9, 3 sites |
iPTMneti | B5D5N9 |
PhosphoSitePlusi | B5D5N9 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000011016, Expressed in liver and 20 other tissues |
Interactioni
Protein-protein interaction databases
BioGRIDi | 249135, 1 interactor |
STRINGi | 10116.ENSRNOP00000055811 |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1286, Eukaryota |
GeneTreei | ENSGT00940000160440 |
HOGENOMi | CLU_007946_15_7_1 |
InParanoidi | B5D5N9 |
OMAi | HMPKAII |
OrthoDBi | 439017at2759 |
PhylomeDBi | B5D5N9 |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR004755, Cat_AA_permease IPR029485, CAT_C |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit PF13906, AA_permease_C, 1 hit |
TIGRFAMsi | TIGR00906, 2A0303, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: B5D5N9-1) [UniParc]FASTAAdd to basket
Also known as: CAT2A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIPCRAVLTF TRCLIRRKIV TLDSLEDSKL CRCLTTMDLI ALGVGSTLGA
60 70 80 90 100
GVYVLAGEVA KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY
110 120 130 140 150
LYTYVTVGEL WAFITGWNLI LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF
160 170 180 190 200
KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL SFGVKESAWV NKFFTAINIL
210 220 230 240 250
VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG TSIYGAGGFM
260 270 280 290 300
PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF
310 320 330 340 350
MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVGWGPAKYV VAAGSLCALS
360 370 380 390 400
TSLLGSMFPL PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM
410 420 430 440 450
AFLFDLKALV DMMSIGTLMA YSLVAACVLI LRYQPGLCYE QPKYTPEKDI
460 470 480 490 500
LESCTNATSK SESQVTMLQG QGFSLRTLFN PSALPTRQSA SLVSFLVGFL
510 520 530 540 550
AFLIAGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCAAVI LTIWRQPQNQ
560 570 580 590 600
QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWVRFSIWM VLGFLIYFAY
610 620 630 640 650
GIRHSLEGNP RDEEEDEDVC PDNVNAAAEE KSAMQANDHH QRNLSLPFIL
HEKTSEC
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037355 | 357 – 397 | MFPLP…AGVIS → IFPMPRVIYAMAEDGLLFKC LAQINSKTKTPIIATLSSGA VA in isoform 2. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF245001 mRNA Translation: AAQ14243.1 AF245002 mRNA Translation: AAQ14244.1 CH473995 Genomic DNA Translation: EDL78824.1 CH473995 Genomic DNA Translation: EDL78825.1 |
RefSeqi | NP_001128158.1, NM_001134686.2 [B5D5N9-2] NP_072141.2, NM_022619.3 [B5D5N9-1] |
Genome annotation databases
Ensembli | ENSRNOT00000014809; ENSRNOP00000014809; ENSRNOG00000011016 [B5D5N9-2] ENSRNOT00000015127; ENSRNOP00000015127; ENSRNOG00000011016 [B5D5N9-1] |
GeneIDi | 64554 |
KEGGi | rno:64554 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF245001 mRNA Translation: AAQ14243.1 AF245002 mRNA Translation: AAQ14244.1 CH473995 Genomic DNA Translation: EDL78824.1 CH473995 Genomic DNA Translation: EDL78825.1 |
RefSeqi | NP_001128158.1, NM_001134686.2 [B5D5N9-2] NP_072141.2, NM_022619.3 [B5D5N9-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 249135, 1 interactor |
STRINGi | 10116.ENSRNOP00000055811 |
PTM databases
GlyGeni | B5D5N9, 3 sites |
iPTMneti | B5D5N9 |
PhosphoSitePlusi | B5D5N9 |
Proteomic databases
jPOSTi | B5D5N9 |
PeptideAtlasi | B5D5N9 |
PRIDEi | B5D5N9 |
Genome annotation databases
Ensembli | ENSRNOT00000014809; ENSRNOP00000014809; ENSRNOG00000011016 [B5D5N9-2] ENSRNOT00000015127; ENSRNOP00000015127; ENSRNOG00000011016 [B5D5N9-1] |
GeneIDi | 64554 |
KEGGi | rno:64554 |
Organism-specific databases
CTDi | 6542 |
RGDi | 68387, Slc7a2 |
Phylogenomic databases
eggNOGi | KOG1286, Eukaryota |
GeneTreei | ENSGT00940000160440 |
HOGENOMi | CLU_007946_15_7_1 |
InParanoidi | B5D5N9 |
OMAi | HMPKAII |
OrthoDBi | 439017at2759 |
PhylomeDBi | B5D5N9 |
Enzyme and pathway databases
Reactomei | R-RNO-352230, Amino acid transport across the plasma membrane |
Miscellaneous databases
PROi | PR:B5D5N9 |
Gene expression databases
Bgeei | ENSRNOG00000011016, Expressed in liver and 20 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR004755, Cat_AA_permease IPR029485, CAT_C |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit PF13906, AA_permease_C, 1 hit |
TIGRFAMsi | TIGR00906, 2A0303, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTR2_RAT | |
Accessioni | B5D5N9Primary (citable) accession number: B5D5N9 Secondary accession number(s): B5D5P0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 26, 2009 |
Last sequence update: | October 14, 2008 | |
Last modified: | December 2, 2020 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families