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Entry version 100 (02 Jun 2021)
Sequence version 2 (05 Jun 2019)
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Protein
Submitted name:

MIF4G domain-containing protein

Gene

ifg-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MIF4G domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ifg-1Imported
ORF Names:CELE_M110.4Imported, M110.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
M110.4d ; CE53041 ; WBGene00002066 ; ifg-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
B5BM24

PeptideAtlas

More...
PeptideAtlasi
B5BM24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002066, Expressed in adult organism and 6 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B5BM24, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini521 – 751MIF4GInterPro annotationAdd BLAST231

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 94DisorderedSequence analysisAdd BLAST94
Regioni115 – 142DisorderedSequence analysisAdd BLAST28
Regioni273 – 349DisorderedSequence analysisAdd BLAST77
Regioni431 – 505DisorderedSequence analysisAdd BLAST75
Regioni755 – 940DisorderedSequence analysisAdd BLAST186

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 94Polar residuesSequence analysisAdd BLAST74
Compositional biasi273 – 306Polar residuesSequence analysisAdd BLAST34
Compositional biasi329 – 349Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi431 – 465Polar residuesSequence analysisAdd BLAST35
Compositional biasi466 – 482Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi755 – 798Basic and acidic residuesSequence analysisAdd BLAST44
Compositional biasi800 – 817Polar residuesSequence analysisAdd BLAST18
Compositional biasi833 – 857Polar residuesSequence analysisAdd BLAST25
Compositional biasi867 – 881Polar residuesSequence analysisAdd BLAST15
Compositional biasi888 – 902Basic and acidic residuesSequence analysisAdd BLAST15

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166420

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_275973_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEMELWE

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02854, MIF4G, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00543, MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

B5BM24-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNAVSRGPG RGKPNQGFHS DHNAVPMQDS SQQFVMPFVN TSGPVNSNYQ
60 70 80 90 100
RMPMNQSAYP QYGQQQYNQP QTNHYYPPQA PQHQQQYGGY QRPDYGHQPQ
110 120 130 140 150
MYNQQYQGYQ APQQYHPEMP YQPAQPAQQQ MTHTAPQEPK RQRKALEIVD
160 170 180 190 200
PTTKKAIEVT PHLAPAAPAP AAPAAPIAPE EEKKKQNITL EFLNQVKNEL
210 220 230 240 250
HHEDRRHDNP PAVPAAVPAA VQAAVLPNFS VPPPALGQTP PAASIAPQVV
260 270 280 290 300
PSVPKTPEAP AKADYEVKQA ETLVTPVSSP HASDTTTTTP ASGTAESAST
310 320 330 340 350
VADVRVTPTL TKEESKEETD DDKFEENDER ESTPDVADSS TEKTPEELEI
360 370 380 390 400
EKAQKEAEEI EKKKLREEAL EKRIEELILA GSAVISDGTF GRDFMVTIRE
410 420 430 440 450
IEKVFSRTPC PLSPAQLADF GLDIKTMRVS DNKKPNFTPN WANKGGNRQQ
460 470 480 490 500
PYRGRTTTDG TGRGGQQQRD RMHNKRPPVV RPSIERVQRV TLPSSKDAWK
510 520 530 540 550
PDRQKTAEAV ASEEAAVIEV CKKVRSLMNK VTPTSQRPLT EEFISYNVSS
560 570 580 590 600
NDAQLAQVVE IVFDKAVEEP KFCALYAEMC KAQANHELSQ TGGKSAFRNK
610 620 630 640 650
VLTRTQMTFQ DKKDIDADKL AIIEKEEDPV KKELMLAEEK QKFRRRKFGV
660 670 680 690 700
MTFMGYLYRN QLLSTKIVQT CTFELFNSIK DQDIKKEDVD EESIHCGLQL
710 720 730 740 750
IETVGVMLDK SKDSTTVFLD QWFQKLEAAK PYCSNKIRFM IMNLMELRKD
760 770 780 790 800
KWIPRKSTES GPKKIDEIHK DIRQEKIENE KARDQYDRDR DRRHGGVRPN
810 820 830 840 850
SNSLRKSVPV SRNSLDRNRG MQHPEQKRAA AAANTKLASS SVQPKNISLS
860 870 880 890 900
SMDNNTLGKS KKEWHSGASG GGNTSSESAV PVKSAWGRRD SNDQRKKSTV
910 920 930 940 950
DEKQAALAAA KEISAMSISS RRSTSQNSNT DKTDDELTEE EKAVRAKIMN
960 970 980 990 1000
TVKSDLLEMS SGELSQKELV DSITDYVGKE KYGSPSLTVV YEMIIRAVIE
1010 1020 1030 1040 1050
KGLKDDDRKK LAIALRMSLV SKTEKQAFIE GATRFCKFAN DVELQQDYPK
1060 1070 1080 1090 1100
LWTVTGEVLV NTSHAPHDEI GEVESFSLAD MKPIFSAAKG EGNKKFDLLV
1110 1120 1130 1140 1150
QVLKQLIELE LEVTGAAEGI SWEFSDMKLK TEMEEGLSAE MEAVTFKNGK

TLSSYLTGN
Length:1,159
Mass (Da):129,604
Last modified:June 5, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46BA49759B4504F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q21531Q21531_CAEEL
MIF4G domain-containing protein
ifg-1 CELE_M110.4, M110.4
1,156Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7JMF0Q7JMF0_CAEEL
MIF4G domain-containing protein
ifg-1 CELE_M110.4, M110.4
1,155Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5BM23B5BM23_CAEEL
MIF4G domain-containing protein
ifg-1 CELE_M110.4, M110.4
1,042Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A486WX07A0A486WX07_CAEEL
MIF4G domain-containing protein
ifg-1 CELE_M110.4, M110.4
1,160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAR31496.2

NCBI Reference Sequences

More...
RefSeqi
NP_001129820.1, NM_001136348.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
M110.4d.1; M110.4d.1; WBGene00002066

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAR31496.2
RefSeqiNP_001129820.1, NM_001136348.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiB5BM24
PeptideAtlasiB5BM24

Genome annotation databases

EnsemblMetazoaiM110.4d.1; M110.4d.1; WBGene00002066

Organism-specific databases

WormBaseiM110.4d ; CE53041 ; WBGene00002066 ; ifg-1

Phylogenomic databases

GeneTreeiENSGT00940000166420
HOGENOMiCLU_275973_0_0_1
OMAiVEMELWE

Gene expression databases

BgeeiWBGene00002066, Expressed in adult organism and 6 other tissues
ExpressionAtlasiB5BM24, baseline and differential

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
PfamiView protein in Pfam
PF02854, MIF4G, 1 hit
SMARTiView protein in SMART
SM00543, MIF4G, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB5BM24_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B5BM24
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: June 5, 2019
Last modified: June 2, 2021
This is version 100 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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