UniProtKB - B5B9L6 (B5B9L6_HUMAN)
Protein
L-Fucosyltransferase
Gene
FUT2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- a β-D-Gal-(1→3)-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-Glc-(1↔1ʼ)-Cer(d18:1(4E)) + GDP-β-L-fucose = α-L-fucosyl-(1→2)- β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1ʼ)-N-acylsphing-4-enine + GDP + H+ARBA annotationEC:2.4.1.69ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- a neolactoside nLc4Cer(d18:1(4E)) + GDP-β-L-fucose = a neolactoside IV2-α-Fuc-nLc4Cer(d18:1(4E)) + GDP + H+ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- β-D-galactosyl-(1→3)-N-acetyl-D-galactosamine + GDP-β-L-fucose = α-L-fucosyl-(1→2)-β-D-galactosyl-(1→3)-N-acetyl-D-galactosamine + GDP + H+ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
- This reaction proceeds in the forwardARBA annotation direction.
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotationARBA annotationView all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
GO - Molecular functioni
- galactoside 2-alpha-L-fucosyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- carbohydrate metabolic process Source: InterPro
- protein glycosylation Source: UniProtKB-UniPathway
Keywordsi
Molecular function | GlycosyltransferaseUniRule annotationImportedARBA annotation, Transferase |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:FUT2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Golgi apparatus
- Golgi stack membrane UniRule annotationARBA annotation; Single-pass type II membrane protein UniRule annotationARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Golgi apparatus
- Golgi cisterna membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 28 | HelicalUniRule annotationAdd BLAST | 17 |
Keywords - Cellular componenti
Golgi apparatusUniRule annotation, MembranePTM / Processingi
Keywords - PTMi
GlycoproteinUniRule annotationProteomic databases
PeptideAtlasi | B5B9L6 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationFamily and domain databases
InterProi | View protein in InterPro IPR002516, Glyco_trans_11 |
PANTHERi | PTHR11927, PTHR11927, 1 hit |
Pfami | View protein in Pfam PF01531, Glyco_transf_11, 1 hit |
i Sequence
Sequence statusi: Complete.
B5B9L6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVVQMPFSF PMAHFILFVF TVSTIFHVQQ RLAKIQAMWE LPVQIPVLAS
60 70 80 90 100
TSKALGPSQL RGMWTINAIG RLGNQMGEYA TLYALAKMNG RPAFIPAQMH
110 120 130 140 150
STLAPIFRIT LPVLHSATAS RIPWQNYHLN DWMEEEYRHI PGEYVRFTSY
160 170 180 190 200
PCSWTFYHHL RQEILQEFTL HDHVREEAQK FLRGLQVNGS RPGTFVGVHV
210 220 230 240 250
RRGDYVHVMP KVWKGVVADR RYLQQALDWF RARYSSLIFV VTSNGMAWCR
260 270 280 290 300
ENIDTSHGDV VFAGDGIEGS PAKDFALLTQ CNHTIMTIGT FGIWAAYLTG
310 320 330 340
GDTIYLANYT LPDSPFLKIF KPEAAFLPEW TGIAADLSPL LKH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180558 Genomic DNA Translation: CAQ81978.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM180558 Genomic DNA Translation: CAQ81978.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B5B9L6 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Miscellaneous databases
ChiTaRSi | FUT2, human |
Family and domain databases
InterProi | View protein in InterPro IPR002516, Glyco_trans_11 |
PANTHERi | PTHR11927, PTHR11927, 1 hit |
Pfami | View protein in Pfam PF01531, Glyco_transf_11, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B5B9L6_HUMAN | |
Accessioni | B5B9L6Primary (citable) accession number: B5B9L6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | December 2, 2020 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |