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Protein
Submitted name:

Nuclear factor of activated T-cells c3 isoform IAL-Xa

Gene

Nfatc3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-2025928 Calcineurin activates NFAT
R-MMU-2871809 FCERI mediated Ca+2 mobilization
R-MMU-5607763 CLEC7A (Dectin-1) induces NFAT activation

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor of activated T-cells c3 isoform IAL-XaImported
Submitted name:
Nuclear factor of-activated T-cells, cytoplasmic 3Imported
Gene namesi
Name:Nfatc3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:103296 Nfatc3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini408 – 589RHDInterPro annotationAdd BLAST182

Phylogenomic databases

eggNOGiENOG410IIAD Eukaryota
ENOG4111EMW LUCA
GeneTreeiENSGT00550000074562
HOVERGENiHBG069754

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR008366 NFAT
IPR008967 p53-like_TF_DNA-bd
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR12533 PTHR12533, 1 hit
PfamiView protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR01789 NUCFACTORATC
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50254 REL_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

B5B2U1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRPRRVLFS VSAQLPSRTR PGPSDLDLEP DDCASIYIFN VDPPPSTLNS
60 70 80 90 100
SLGLPHHGLL QSHSSVLSPS FQLQGYKNYE GTGDISESKY SPLGGPKPFE
110 120 130 140 150
CPSIQITSIS PNCHQGTDAH EDDLHINDPE REYLERPSRD HLYLPLEPSY
160 170 180 190 200
RESSLSPSPA SSISSRSWFS DASSCESLSH IYDDVDSELN EAAARFTLGS
210 220 230 240 250
PLTSPGGSPG GCPGEESWHQ QYGSGHSLSP RQSPCHSPRS SITDENWLSP
260 270 280 290 300
RPASGPSSRP TSPCGKRRHS SAEVCYAGSL SPHHSPVPSP GHSPRGSVTE
310 320 330 340 350
DTWLTAPVHT GSGLSPAPFP FQYCVETDIP LKTRKTSEDQ AAILPGKLEI
360 370 380 390 400
CSDDQGNLSP SRETSVDDGL GSQYPLKKDS SGDQFLSVPS PFTWSKPKPG
410 420 430 440 450
HTPIFRTSSL PPLDWPLPTH FGQCELKIEV QPKTHHRAHY ETEGSRGAVK
460 470 480 490 500
ASTGGHPVVK LLGYSEKPIN LQMFIGTADD RYLRPHAFYQ VHRITGKTVA
510 520 530 540 550
TASQEIIIAS TKVLEIPLLP ENNMSASIDC AGILKLRNSD IELRKGETDI
560 570 580 590 600
GRKNTRVRLV FRVHIPQPSG KVLSLQIASI PVECSQRSAQ ELPHIEKYSI
610 620 630 640 650
NSCSVNGGHE MIVTGSNFLP ESKIIFLEKG QDGRPHWEAE GKIIREKCQG
660 670 680 690 700
AHIVLEVPPY HNPAVTSAVQ VHFYLCNGKR KKSQSQRFTY TPVLMKQEQR
710 720 730 740 750
EDTDLPSVPS LPVPHSAQAQ RPSSETGHPH DRAMSAPGSL LCQVQPAYTS
760 770 780 790 800
MVASTHLPQL QCRDEGAGKE QHIATSSVMH QPFQVTPTSP IGSSYQSIQT
810 820 830 840 850
SMYNGPTCLP VNPASSQEFD PVLFQQDAAL SSLVNLGCQP LSPIPFHSSN
860 870 880 890 900
SDATGHLLAH SPHSVQTPPH LQSMGYHCSN AGQTALSSPV ADQITGQPSS
910 920 930 940 950
HLQPITYCPS HPGSATAASP AASHPLASSP ISGPSSPQLQ PMPYQSPSSG
960 970 980 990 1000
TASSPSPTTR MHSGQHSTQA QSTGQGGLSV PSSLVCHSLC DPASFPPGGA
1010 1020 1030 1040 1050
TVSIKPEPED QEPNFATIGL QDITLDDDQF ISDLEHQPSG STEKWPNHSE
1060
FSCPVPFWRI
Length:1,060
Mass (Da):114,491
Last modified:September 23, 2008 - v1
Checksum:i358420E756821C8D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P97305NFAC3_MOUSE
Nuclear factor of activated T-cells...
Nfatc3 Nfat4
1,075Annotation score:
Q3UZ64Q3UZ64_MOUSE
Nuclear factor of activated T-cells...
Nfatc3 mCG_20471
1,076Annotation score:
B5B2U2B5B2U2_MOUSE
Nuclear factor of activated T-cells...
Nfatc3
1,068Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133195 Genomic DNA No translation available.
AC133499 Genomic DNA No translation available.
EU887626 mRNA Translation: ACG55646.1
UniGeneiMm.383185

Genome annotation databases

EnsembliENSMUST00000211991; ENSMUSP00000148556; ENSMUSG00000031902
UCSCiuc009nfe.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133195 Genomic DNA No translation available.
AC133499 Genomic DNA No translation available.
EU887626 mRNA Translation: ACG55646.1
UniGeneiMm.383185

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000211991; ENSMUSP00000148556; ENSMUSG00000031902
UCSCiuc009nfe.2 mouse

Organism-specific databases

MGIiMGI:103296 Nfatc3

Phylogenomic databases

eggNOGiENOG410IIAD Eukaryota
ENOG4111EMW LUCA
GeneTreeiENSGT00550000074562
HOVERGENiHBG069754

Enzyme and pathway databases

ReactomeiR-MMU-2025928 Calcineurin activates NFAT
R-MMU-2871809 FCERI mediated Ca+2 mobilization
R-MMU-5607763 CLEC7A (Dectin-1) induces NFAT activation

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR008366 NFAT
IPR008967 p53-like_TF_DNA-bd
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR12533 PTHR12533, 1 hit
PfamiView protein in Pfam
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR01789 NUCFACTORATC
SMARTiView protein in SMART
SM00429 IPT, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50254 REL_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB5B2U1_MOUSE
AccessioniPrimary (citable) accession number: B5B2U1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 12, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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