UniProtKB - B5B0C2 (B5B0C2_HUMAN)
Protein
Submitted name:
G protein-coupled receptor 65
Gene
GPR65
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: G protein-coupled receptor 65ImportedSubmitted name: Orphan GPCR 65Imported |
Gene namesi | Name:GPR65Imported ORF Names:hCG_1642415Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000140030.5 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 15 – 38 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 50 – 71 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 91 – 110 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 130 – 151 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 185 – 203 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 224 – 248 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000140030, Expressed in blood and 144 other tissues |
ExpressionAtlasi | B5B0C2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 290 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 260 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_009579_8_2_1 |
OMAi | TGRSDMW |
OrthoDBi | 987208at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR005464, Psych_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01649, PSYCHOSINER |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B5B0C2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSTCIEEQH DLDHYLFPIV YIFVIIVSIP ANIGSLCVSF LQAKKESELG
60 70 80 90 100
IYLFSLSLSD LLYALTLPLW IDYTWNKDNW TFSPALCKGS AFLMYMNFYS
110 120 130 140 150
STAFLTCIAV DRYLAVVYPL KFFFLRTRRF ALMVSLSIWI LETIFNAVML
160 170 180 190 200
WEDETVVEYC DAEKSNFTLC YDKYPLEKWQ INLNLFRTCT GYAIPLVTIL
210 220 230 240 250
ICNRKVYQAV RHNKATENKE KKRIIKLLVS ITVTFVLCFT PFHVMLLIRC
260 270 280 290 300
ILEHAVNFED HSNSGKRTYT MYRITVALTS LNCVADPILY CFVTETGRYD
310 320 330
MWNILKFCTG RCNTSQRQRK RILSVSTKDT MELEVLE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU883574 mRNA Translation: ACG60648.1 CH471061 Genomic DNA Translation: EAW81365.1 |
RefSeqi | NP_003599.2, NM_003608.3 |
Genome annotation databases
GeneIDi | 8477 |
KEGGi | hsa:8477 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU883574 mRNA Translation: ACG60648.1 CH471061 Genomic DNA Translation: EAW81365.1 |
RefSeqi | NP_003599.2, NM_003608.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
BindingDBi | B5B0C2 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 13320, 219 antibodies |
DNASUi | 8477 |
Genome annotation databases
GeneIDi | 8477 |
KEGGi | hsa:8477 |
Organism-specific databases
CTDi | 8477 |
PharmGKBi | PA28909 |
VEuPathDBi | HostDB:ENSG00000140030.5 |
Phylogenomic databases
HOGENOMi | CLU_009579_8_2_1 |
OMAi | TGRSDMW |
OrthoDBi | 987208at2759 |
Miscellaneous databases
BioGRID-ORCSi | 8477, 7 hits in 993 CRISPR screens |
GenomeRNAii | 8477 |
Gene expression databases
Bgeei | ENSG00000140030, Expressed in blood and 144 other tissues |
ExpressionAtlasi | B5B0C2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR005464, Psych_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01649, PSYCHOSINER |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B5B0C2_HUMAN | |
Accessioni | B5B0C2Primary (citable) accession number: B5B0C2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | April 7, 2021 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |