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Protein

Alanine racemase

Gene

alr

Organism
Streptococcus equi subsp. zooepidemicus (strain MGCS10565)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Active sitei263Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei310Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciSEQU552526:G1GCI-398-MONOMER
UniPathwayi
UPA00042;UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:Sez_0369
OrganismiStreptococcus equi subsp. zooepidemicus (strain MGCS10565)
Taxonomic identifieri552526 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001873 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001386251 – 366Alanine racemaseAdd BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliB4U178
SMRiB4U178
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

B4U178-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISSLHRPTV ARVDLEAIQA NIDKIQRHIP KKVKTYAVVK ANAYGHGAVA
60 70 80 90 100
VSKAVEDQVD GYCVSNLDEA LELRQAGIDK EILILGVILA SELQLAIKHQ
110 120 130 140 150
LTITVASLEW LELAKKESVD FSQLHVHVKV DSGMGRIGVR SLAEANQLIS
160 170 180 190 200
ILSDMGVQLD GIFTHFATAD ESDHAMFDKQ LTFFKQLVEQ LDKRPALVHA
210 220 230 240 250
SNSATSLWHS ETIFNAIRLG IVIYGLNPSG NSLSLPCPLK EALSLESRLV
260 270 280 290 300
HVKQIQAGDS VGYGASYVAA ESEYVGTLPI GYADGWTRNM QGFKVLVEGE
310 320 330 340 350
FCDIIGRVSM DQLTIRLLQA YPIGTKVTLI GQQGKQVITA TDVADYRGTI
360
NYEVLCLLSD RIPREY
Length:366
Mass (Da):40,143
Last modified:September 23, 2008 - v1
Checksum:i35614E47486130AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001129 Genomic DNA Translation: ACG61745.1
RefSeqiWP_012515021.1, NC_011134.1

Genome annotation databases

EnsemblBacteriaiACG61745; ACG61745; Sez_0369
KEGGisez:Sez_0369

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001129 Genomic DNA Translation: ACG61745.1
RefSeqiWP_012515021.1, NC_011134.1

3D structure databases

ProteinModelPortaliB4U178
SMRiB4U178
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACG61745; ACG61745; Sez_0369
KEGGisez:Sez_0369

Phylogenomic databases

HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

BioCyciSEQU552526:G1GCI-398-MONOMER

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALR_STREM
AccessioniPrimary (citable) accession number: B4U178
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: October 10, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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