UniProtKB - B4TCQ3 (ARGE_SALHS)
Protein
Acetylornithine deacetylase
Gene
argE
Organism
Salmonella heidelberg (strain SL476)
Status
Functioni
Catalytic activityi
- EC:3.5.1.16UniRule annotation
Cofactori
Protein has several cofactor binding sites:- Zn2+UniRule annotation, Co2+UniRule annotationNote: Binds 2 Zn2+ or Co2+ ions per subunit.UniRule annotation
- glutathioneUniRule annotation
: L-arginine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear).UniRule annotationProteins known to be involved in this subpathway in this organism are:
- Acetylornithine deacetylase (argE)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear), the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 80 | Cobalt or zinc 1UniRule annotation | 1 | |
Active sitei | 82 | UniRule annotation | 1 | |
Metal bindingi | 112 | Cobalt or zinc 1UniRule annotation | 1 | |
Metal bindingi | 112 | Cobalt or zinc 2UniRule annotation | 1 | |
Active sitei | 144 | UniRule annotation | 1 | |
Metal bindingi | 145 | Cobalt or zinc 2UniRule annotation | 1 | |
Metal bindingi | 169 | Cobalt or zinc 1UniRule annotation | 1 | |
Metal bindingi | 355 | Cobalt or zinc 2UniRule annotation | 1 |
GO - Molecular functioni
- acetylornithine deacetylase activity Source: UniProtKB-UniRule
- metallopeptidase activity Source: InterPro
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- arginine biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Hydrolase |
Biological process | Amino-acid biosynthesis, Arginine biosynthesis |
Ligand | Cobalt, Metal-binding, Zinc |
Enzyme and pathway databases
UniPathwayi | UPA00068;UER00110 |
Names & Taxonomyi
Protein namesi | Recommended name: Acetylornithine deacetylaseUniRule annotation (EC:3.5.1.16UniRule annotation)Short name: AOUniRule annotation Short name: AcetylornithinaseUniRule annotation Alternative name(s): N-acetylornithinaseUniRule annotation Short name: NAOUniRule annotation |
Gene namesi | Name:argEUniRule annotation Ordered Locus Names:SeHA_C4448 |
Organismi | Salmonella heidelberg (strain SL476) |
Taxonomic identifieri | 454169 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000137077 | 1 – 383 | Acetylornithine deacetylaseAdd BLAST | 383 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | HOG000243769 |
KOi | K01438 |
OMAi | CAHQPGE |
Family and domain databases
HAMAPi | MF_01108 ArgE, 1 hit |
InterProi | View protein in InterPro IPR010169 AcOrn-deacetyl IPR001261 ArgE/DapE_CS IPR036264 Bact_exopeptidase_dim_dom IPR002933 Peptidase_M20 IPR011650 Peptidase_M20_dimer |
PANTHERi | PTHR43808:SF1 PTHR43808:SF1, 1 hit |
Pfami | View protein in Pfam PF07687 M20_dimer, 1 hit PF01546 Peptidase_M20, 1 hit |
SUPFAMi | SSF55031 SSF55031, 1 hit |
TIGRFAMsi | TIGR01892 AcOrn-deacetyl, 1 hit |
PROSITEi | View protein in PROSITE PS00758 ARGE_DAPE_CPG2_1, 1 hit PS00759 ARGE_DAPE_CPG2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B4TCQ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKNVLPPFIE IYRALIATPS ISATEESLDQ SNASLITLLA GWFSDLGFNV
60 70 80 90 100
EVQPVPGTRN KFNMLASTGH GAGGLLLTGH TDTVPFDDGR WTRDPFTLTE
110 120 130 140 150
HDNKLYGLGT ADMKGFFAFI LDALRDVDVT KLKKPLYILA TADEETSMAG
160 170 180 190 200
ARYFSETTAL RPDCAIIGEP TSLQPIRAHK GHISNVVRVL GQSGHSSDPA
210 220 230 240 250
RGVNAIELMH DAIGHIMQLR DSLKTRYHYE AFTVPYPTLN LGHIHGGDAS
260 270 280 290 300
NRICACCELH MDIRPLPGMT LNDLNGLLND ALAPVSERWP GRLTVAELHP
310 320 330 340 350
PIPGYECPPD HQLVEVVEKL LGTKTDVVNY CTEAPFMQTL CPTLVLGPGS
360 370 380
INQAHQPDEY LETRFIKPTR ELITQVVHHF CWH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001120 Genomic DNA Translation: ACF69281.1 |
RefSeqi | WP_000800209.1, NC_011083.1 |
Genome annotation databases
EnsemblBacteriai | ACF69281; ACF69281; SeHA_C4448 |
KEGGi | seh:SeHA_C4448 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001120 Genomic DNA Translation: ACF69281.1 |
RefSeqi | WP_000800209.1, NC_011083.1 |
3D structure databases
SMRi | B4TCQ3 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | ACF69281; ACF69281; SeHA_C4448 |
KEGGi | seh:SeHA_C4448 |
Phylogenomic databases
HOGENOMi | HOG000243769 |
KOi | K01438 |
OMAi | CAHQPGE |
Enzyme and pathway databases
UniPathwayi | UPA00068;UER00110 |
Family and domain databases
HAMAPi | MF_01108 ArgE, 1 hit |
InterProi | View protein in InterPro IPR010169 AcOrn-deacetyl IPR001261 ArgE/DapE_CS IPR036264 Bact_exopeptidase_dim_dom IPR002933 Peptidase_M20 IPR011650 Peptidase_M20_dimer |
PANTHERi | PTHR43808:SF1 PTHR43808:SF1, 1 hit |
Pfami | View protein in Pfam PF07687 M20_dimer, 1 hit PF01546 Peptidase_M20, 1 hit |
SUPFAMi | SSF55031 SSF55031, 1 hit |
TIGRFAMsi | TIGR01892 AcOrn-deacetyl, 1 hit |
PROSITEi | View protein in PROSITE PS00758 ARGE_DAPE_CPG2_1, 1 hit PS00759 ARGE_DAPE_CPG2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARGE_SALHS | |
Accessioni | B4TCQ3Primary (citable) accession number: B4TCQ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 14, 2009 |
Last sequence update: | September 23, 2008 | |
Last modified: | October 16, 2019 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families - PATHWAY comments
Index of metabolic and biosynthesis pathways