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Protein

Mesencephalic astrocyte-derived neurotrophic factor homolog

Gene

Manf

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Mesencephalic astrocyte-derived neurotrophic factor homolog
Alternative name(s):
MANF/CDNF-like protein
Gene namesi
Name:ManfBy similarity
ORF Names:GD19093
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000304 Componentsi: Chromosome 3R, Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0190600 Dsim\GD19093

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000039094523 – 173Mesencephalic astrocyte-derived neurotrophic factor homologAdd BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 114By similarity
Disulfide bondi31 ↔ 103By similarity
Disulfide bondi61 ↔ 72By similarity
Disulfide bondi148 ↔ 151By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiFBgn0190600

Structurei

3D structure databases

SMRiB4QX46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARMET family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

KOiK22556
OMAiNRFCYYL
OrthoDBiEOG091G0P3O
PhylomeDBiB4QX46

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR019345 Armet_prot
IPR018247 EF_Hand_1_Ca_BS
IPR036361 SAP_dom_sf
PANTHERiPTHR12990 PTHR12990, 1 hit
PfamiView protein in Pfam
PF10208 Armet, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4QX46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTWHMVVVI GFLATLAQTS LALKEEDCEV CVKTVRRFAD SLDDSTKKDY
60 70 80 90 100
KQIETAFKKF CKAQKNKEHR FCYYLGGLEE SATGILNELS KPLSWSMPAE
110 120 130 140 150
KICEKLKKKD AQICDLRYEK QIDLNSVDLK KLKVRDLKKI LNDWDESCDG
160 170
CLEKGDFIKR IEELKPKYSR SEL
Length:173
Mass (Da):20,110
Last modified:September 23, 2008 - v1
Checksum:iF371BC3A915A0197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000364 Genomic DNA Translation: EDX12700.1
RefSeqiXP_002103197.1, XM_002103161.2

Genome annotation databases

EnsemblMetazoaiFBtr0219003; FBpp0217495; FBgn0190600
GeneIDi6727838
KEGGidsi:Dsimw501_GD19093

Similar proteinsi

Entry informationi

Entry nameiARMET_DROSI
AccessioniPrimary (citable) accession number: B4QX46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: June 20, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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