UniProtKB - B4QVV3 (CRBN_DROSI)
Protein
Protein cereblon homolog
Gene
GD18661
Organism
Drosophila simulans (Fruit fly)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 457 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 460 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 526 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 529 | ZincPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Protein cereblon homolog |
Gene namesi | ORF Names:GD18661 |
Organismi | Drosophila simulans (Fruit fly) |
Taxonomic identifieri | 7240 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0190182 Dsim\GD18661 |
Subcellular locationi
Nucleus
- nucleus Source: EnsemblMetazoa
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000393886 | 1 – 587 | Protein cereblon homologAdd BLAST | 587 |
Expressioni
Gene expression databases
Bgeei | FBgn0190182 Expressed in 4 organ(s), highest expression level in male reproductive system |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 227 – 451 | Lon N-terminalPROSITE-ProRule annotationAdd BLAST | 225 | |
Domaini | 452 – 561 | CULTPROSITE-ProRule annotationAdd BLAST | 110 |
Sequence similaritiesi
Belongs to the CRBN family.Curated
Phylogenomic databases
KOi | K11793 |
OMAi | KRQLHEW |
PhylomeDBi | B4QVV3 |
Family and domain databases
CDDi | cd15777 CRBN_C_like, 1 hit |
InterProi | View protein in InterPro IPR034750 CULT IPR003111 Lon_substr-bd IPR004910 Yippee/Mis18/Cereblon |
Pfami | View protein in Pfam PF03226 Yippee-Mis18, 1 hit |
PROSITEi | View protein in PROSITE PS51788 CULT, 1 hit PS51787 LON_N, 1 hit |
i Sequence
Sequence statusi: Complete.
B4QVV3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDEEENSEIN SVQARNEDVQ LEDQSQSQGL QDRQVDAIEQ AWNDAMPDEP
60 70 80 90 100
SPPAEYAFHD PLAIVGEGGD APEAMVEDVL QDDTASEGSH PSSDMSLESP
110 120 130 140 150
GSEDDSDVQG LPNWMIPQNR LRSAVDMMVS QARNRDGGIA ALLSGDNFLQ
160 170 180 190 200
RVRSMVFSQE RRRSRTSEET SQEEAAEEPD DPPPQQPPLP PIDIGFDTNL
210 220 230 240 250
PAEHSYFGNH LSRVPGVDYL EVGSVHHMLI FLHHHILFPG EVLPFMIDGQ
260 270 280 290 300
MFDDDMPGLD GLIFGVSFPR LQPPEDNPHK LYGVTCQIYE RGESGRGLVF
310 320 330 340 350
YKSRALQRIV INCDDIKGSP QYIARNPTNK CFSNVKILPE YFLPEPLQSV
360 370 380 390 400
DMGSMARFRD IPSMRDKYRR FQLSTTTWPS DACQEYSFGS IVERARQRLE
410 420 430 440 450
SQKIDTMPKC PIQLSFWLVR NLHLTEKMMR LTFLTDSVNT RLQLIKSTFK
460 470 480 490 500
DETLFFCRYC NSSLALCSDL FAMSKHGVQT QYCNPEGYIH ETNTVYRVIS
510 520 530 540 550
HAIGYSGEPS TKFSWFPGYQ WHIILCKFCA QHVGWEFKAV LPNLTPNVFF
560 570 580
GLSGSSVRIG KASEYSPFNG TTYVVRNMLR MISSDME
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM000364 Genomic DNA Translation: EDX13533.1 |
RefSeqi | XP_002104030.1, XM_002103994.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0218571; FBpp0217063; FBgn0190182 |
GeneIDi | 6728694 |
KEGGi | dsi:Dsimw501_GD18661 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CM000364 Genomic DNA Translation: EDX13533.1 |
RefSeqi | XP_002104030.1, XM_002103994.2 |
3D structure databases
SMRi | B4QVV3 |
ModBasei | Search... |
Genome annotation databases
EnsemblMetazoai | FBtr0218571; FBpp0217063; FBgn0190182 |
GeneIDi | 6728694 |
KEGGi | dsi:Dsimw501_GD18661 |
Organism-specific databases
FlyBasei | FBgn0190182 Dsim\GD18661 |
Phylogenomic databases
KOi | K11793 |
OMAi | KRQLHEW |
PhylomeDBi | B4QVV3 |
Gene expression databases
Bgeei | FBgn0190182 Expressed in 4 organ(s), highest expression level in male reproductive system |
Family and domain databases
CDDi | cd15777 CRBN_C_like, 1 hit |
InterProi | View protein in InterPro IPR034750 CULT IPR003111 Lon_substr-bd IPR004910 Yippee/Mis18/Cereblon |
Pfami | View protein in Pfam PF03226 Yippee-Mis18, 1 hit |
PROSITEi | View protein in PROSITE PS51788 CULT, 1 hit PS51787 LON_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRBN_DROSI | |
Accessioni | B4QVV3Primary (citable) accession number: B4QVV3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 20, 2010 |
Last sequence update: | September 23, 2008 | |
Last modified: | January 16, 2019 | |
This is version 42 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Drosophila
Drosophila: entries, gene names and cross-references to FlyBase